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Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH5.0
Descriptor:	Fab 3H5 Heavy Chain, Fab 3H5 Kappa Chain, Isoform 2 of Cystinosin
Authors:	Schmiege, P, Li, X.
Deposit date:	2022-07-06
Release date:	2022-09-21
Last modified:	2022-10-12
Method:	ELECTRON MICROSCOPY (3.09 Å)
Cite:	Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022

8DKI

Cryo-EM structure of cystinosin in a lumen-open state
Descriptor:	Fab 3H5 Heavy Chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin
Authors:	Schmiege, P, Li, X.
Deposit date:	2022-07-05
Release date:	2022-09-21
Last modified:	2022-10-12
Method:	ELECTRON MICROSCOPY (3.32 Å)
Cite:	Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022

8DKX

Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH7.5
Descriptor:	Fab 3H5 Heavy Chain, Fab 3H5 Kappa Chain, Isoform 2 of Cystinosin
Authors:	Schmiege, P, Li, X.
Deposit date:	2022-07-06
Release date:	2022-09-21
Last modified:	2022-10-12
Method:	ELECTRON MICROSCOPY (3 Å)
Cite:	Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022

8DKM

Cryo-EM structure of cystine-bound cystinosin in a lumen-open state
Descriptor:	Fab 3H5 Heavy Chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin, ...
Authors:	Schmiege, P, Li, X.
Deposit date:	2022-07-05
Release date:	2022-09-21
Last modified:	2022-10-12
Method:	ELECTRON MICROSCOPY (3.39 Å)
Cite:	Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022

5TZU

Crystal structure of human CD47 ECD bound to Fab of B6H12.2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:	Cardoso, R.M.F.
Deposit date:	2016-11-22
Release date:	2017-03-15
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies. Blood Cancer J, 7, 2017

7XRE

Crystal structure of DgpA
Descriptor:	DgpA, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:	Ma, W, He, P.
Deposit date:	2022-05-10
Release date:	2023-02-15
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (2.76 Å)
Cite:	Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C -glycoside cleaving enzyme and an O - to C -glycoside isomerase. Acta Pharm Sin B, 13, 2023

8IDO

Crystal structure of nanobody VHH-T148 with MERS-CoV RBD
Descriptor:	Spike protein S1, VHH-T148, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Wang, X, Tian, L.
Deposit date:	2023-02-14
Release date:	2024-02-28
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structures and neutralizing mechanisms of camel nanobodies targeting the receptor-binding domain of MERS-CoV spike glycoprotein To Be Published

8IDI

Crystal structure of nanobody VHH-T71 with MERS-CoV RBD
Descriptor:	Spike protein S1, VHH-T71, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-mannopyranose-(1-3)][alpha-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Wang, X, Tian, L.
Deposit date:	2023-02-13
Release date:	2024-02-28
Method:	X-RAY DIFFRACTION (1.901 Å)
Cite:	Structural Definition of a Novel Nanobody Binding Site specifically targeting the MERS-CoV RBD Core-Domain with Neutralizing Capacity To Be Published

8IDM

Crystal structure of nanobody VHH-227 with nanobody VHH-T71 and MERS-CoV RBD
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ...
Authors:	Wang, X, Tian, L.
Deposit date:	2023-02-13
Release date:	2024-02-28
Method:	X-RAY DIFFRACTION (3.59 Å)
Cite:	Structural Definition of a Novel Nanobody Binding Site specifically targeting the MERS-CoV RBD Core-Domain with Neutralizing Capacity To Be Published

8IEE

Crystal structure of nanobody VHH-31 with MERS-CoV RBD
Descriptor:	Spike protein S1, VHH-31
Authors:	Wang, X, Tian, L.
Deposit date:	2023-02-15
Release date:	2024-02-28
Method:	X-RAY DIFFRACTION (3.21 Å)
Cite:	Structures and neutralizing mechanisms of camel nanobodies targeting the receptor-binding domain of MERS-CoV spike glycoprotein To Be Published

8IFN

MERS-CoV spike trimer in complex with nanobody VHH-T148
Descriptor:	Spike glycoprotein, VHH-T148, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Wang, X, Tian, L.
Deposit date:	2023-02-19
Release date:	2024-02-28
Method:	ELECTRON MICROSCOPY (2.81 Å)
Cite:	Structures and neutralizing mechanisms of camel nanobodies targeting the receptor-binding domain of MERS-CoV spike glycoprotein To Be Published

7XR9

Crystal structure of DgpA with glucose
Descriptor:	DgpA, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, beta-D-glucopyranose
Authors:	Ma, W, He, P.
Deposit date:	2022-05-09
Release date:	2023-04-05
Last modified:	2024-05-29
Method:	X-RAY DIFFRACTION (2.42 Å)
Cite:	Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C -glycoside cleaving enzyme and an O - to C -glycoside isomerase. Acta Pharm Sin B, 13, 2023

8X83

The cryo-EM structure of insect gustatory receptor Gr43a I418A from Drosophila melanogaster in complex with fructose
Descriptor:	Gustatory receptor for sugar taste 43a, SODIUM ION, beta-D-fructofuranose
Authors:	Ma, D, Guo, J.
Deposit date:	2023-11-27
Release date:	2024-02-07
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (2.8 Å)
Cite:	Structural basis for sugar perception by Drosophila gustatory receptors. Science, 383, 2024

8X82

The cryo-EM structure of insect gustatory receptor Gr43a I418A from Drosophila melanogaster
Descriptor:	Gustatory receptor for sugar taste 43a
Authors:	Ma, D, Guo, J.
Deposit date:	2023-11-27
Release date:	2024-02-07
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (2.8 Å)
Cite:	Structural basis for sugar perception by Drosophila gustatory receptors. Science, 383, 2024

8X84

The cryo-EM structure of insect gustatory receptor Gr43a I418A from Drosophila melanogaster in complex with fructose and calcium
Descriptor:	CALCIUM ION, Gustatory receptor for sugar taste 43a, beta-D-fructofuranose
Authors:	Ma, D, Guo, J.
Deposit date:	2023-11-27
Release date:	2024-02-07
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	Structural basis for sugar perception by Drosophila gustatory receptors. Science, 383, 2024

6X3C

Crystal structure of streptogramin A acetyltransferase VatA from Staphylococcus aureus in complex with streptogramin analog F1037 (47)
Descriptor:	(3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, CHLORIDE ION, MAGNESIUM ION, ...
Authors:	Chaires, H.A, Fraser, J.S.
Deposit date:	2020-05-21
Release date:	2020-11-18
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (3.05 Å)
Cite:	Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020

6X3J

Crystal structure of streptogramin A acetyltransferase VatA from Staphylococcus aureus in complex with streptogramin analog F0224 (46)
Descriptor:	(2R)-2-[(3S,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-4,12-dimethyl-1,7,22-trioxo-4,7,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosin-3-yl]propyl isoquinolin-3-ylcarbamate, CHLORIDE ION, MAGNESIUM ION, ...
Authors:	Chaires, H.A, Fraser, J.S.
Deposit date:	2020-05-21
Release date:	2020-11-18
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020

3O8C

Visualizing ATP-dependent RNA Translocation by the NS3 Helicase from HCV
Descriptor:	HCV NS3 protease/helicase, RNA (5'-R(PUP(5BU)PUPUPUPU)-3'), SULFATE ION, ...
Authors:	Appleby, T.C, Somoza, J.R.
Deposit date:	2010-08-02
Release date:	2011-01-05
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV. J.Mol.Biol., 405, 2011

3O8D

Visualizing ATP-dependent RNA Translocation by the NS3 Helicase from HCV
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, HCV NS3 protease/helicase, ...
Authors:	Appleby, T.C, Somoza, J.R.
Deposit date:	2010-08-02
Release date:	2011-01-05
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV. J.Mol.Biol., 405, 2011

3O8B

Visualizing ATP-dependent RNA Translocation by the NS3 Helicase from HCV
Descriptor:	HCV NS3 protease/helicase, SULFATE ION, ZINC ION
Authors:	Appleby, T.C, Somoza, J.R.
Deposit date:	2010-08-02
Release date:	2011-01-05
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV. J.Mol.Biol., 405, 2011

6LI6

Crystal structure of MCR-1-S treated by Au(PEt3)Cl
Descriptor:	GOLD ION, Probable phosphatidylethanolamine transferase Mcr-1, TRIETHYLPHOSPHANE
Authors:	Zhang, Q, Wang, M, Sun, H.
Deposit date:	2019-12-10
Release date:	2020-09-16
Last modified:	2020-10-28
Method:	X-RAY DIFFRACTION (1.68 Å)
Cite:	Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin. Nat Commun, 11, 2020

7KZR

Structure of the human Fanconi Anaemia Core-UBE2T-ID complex
Descriptor:	E3 ubiquitin-protein ligase FANCL, Fanconi anemia core complex-associated protein 100, Fanconi anemia core complex-associated protein 20, ...
Authors:	Wang, S.L, Pavletich, N.P.
Deposit date:	2020-12-10
Release date:	2021-03-10
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (4.4 Å)
Cite:	Structure of the FA core ubiquitin ligase closing the ID clamp on DNA. Nat.Struct.Mol.Biol., 28, 2021

7KZP

Structure of the human Fanconi anaemia Core complex
Descriptor:	E3 ubiquitin-protein ligase FANCL, Fanconi anemia core complex-associated protein 100, Fanconi anemia core complex-associated protein 20, ...
Authors:	Wang, S.L, Pavletich, N.P.
Deposit date:	2020-12-10
Release date:	2021-03-10
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	Structure of the FA core ubiquitin ligase closing the ID clamp on DNA. Nat.Struct.Mol.Biol., 28, 2021

7KZV

Structure of the human fanconi anaemia Core-UBE2T-ID-DNA complex in closed state
Descriptor:	DNA (29-MER), E3 ubiquitin-protein ligase FANCL, Fanconi anemia core complex-associated protein 100, ...
Authors:	Wang, S.L, Pavletich, N.P.
Deposit date:	2020-12-10
Release date:	2021-03-10
Last modified:	2021-03-24
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Structure of the FA core ubiquitin ligase closing the ID clamp on DNA. Nat.Struct.Mol.Biol., 28, 2021

7KZT

Structure of the human fanconi anaemia Core-UBE2T-ID-DNA complex in intermediate state
Descriptor:	DNA (22-MER), E3 ubiquitin-protein ligase FANCL, Fanconi anemia core complex-associated protein 100, ...
Authors:	Wang, S.L, Pavletich, N.P.
Deposit date:	2020-12-10
Release date:	2021-03-10
Last modified:	2021-03-24
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Structure of the FA core ubiquitin ligase closing the ID clamp on DNA. Nat.Struct.Mol.Biol., 28, 2021

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