7DFG
| Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir | Descriptor: | 6-fluoro-3-oxo-4-(5-O-phosphono-beta-D-ribofuranosyl)-3,4-dihydropyrazine-2-carboxamide, MAGNESIUM ION, Non-structural protein 7, ... | Authors: | Li, Z, Zhou, Z, Yu, X. | Deposit date: | 2020-11-08 | Release date: | 2021-11-17 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for repurpose and design of nucleotide drugs for treating COVID-19 To Be Published
|
|
7DFH
| |
7DOK
| |
7DOI
| |
7X08
| S protein of SARS-CoV-2 in complex with 2G1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | Authors: | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | Deposit date: | 2022-02-21 | Release date: | 2022-03-09 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD. Cell Discov, 8, 2022
|
|
7WD0
| SARS-CoV-2 Beta spike in complex with two S5D2 Fabs | Descriptor: | Heavy chain of S5D2 Fab, Light chain of S5D2 Fab, Spike glycoprotein | Authors: | Wang, Y.F, Cong, Y. | Deposit date: | 2021-12-20 | Release date: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. Emerg Microbes Infect, 11, 2022
|
|
7WDF
| SARS-CoV-2 Beta spike in complex with two S3H3 Fabs | Descriptor: | Heavy chain of S3H3 Fab, Light chain of S3H3 Fab, Spike glycoprotein | Authors: | Wang, Y.F, Cong, Y. | Deposit date: | 2021-12-21 | Release date: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. Emerg Microbes Infect, 11, 2022
|
|
7WD9
| |
7WCR
| |
7WCZ
| SARS-CoV-2 Beta spike in complex with one S5D2 Fab | Descriptor: | Heavy chain of S5D2 Fab, Light chain of S5D2 Fab, Spike glycoprotein | Authors: | Wang, Y.F, Cong, Y. | Deposit date: | 2021-12-20 | Release date: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. Emerg Microbes Infect, 11, 2022
|
|
7WD7
| |
7WD8
| SARS-CoV-2 Beta spike SD1 in complex with S3H3 Fab | Descriptor: | Heavy chain of S3H3 Fab, Light chain of S3H3 Fab, Spike glycoprotein | Authors: | Wang, Y.F, Cong, Y. | Deposit date: | 2021-12-21 | Release date: | 2022-02-02 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. Emerg Microbes Infect, 11, 2022
|
|
7WHK
| The state 3 complex structure of Omicron spike with Bn03 (2-up RBD, 5 nanobodies) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bn03_nano1, Bn03_nano2, ... | Authors: | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | Deposit date: | 2021-12-30 | Release date: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell, 185, 2022
|
|
7WHI
| The state 2 complex structure of Omicron spike with Bn03 (2-up RBD, 4 nanobodies) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bn03_nano1, Bn03_nano2, ... | Authors: | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | Deposit date: | 2021-12-30 | Release date: | 2022-05-11 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell, 185, 2022
|
|
7WHJ
| The state 1 complex structure of Omicron spike with Bn03 (1-up RBD, 3 nanobodies) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Bn03_nano1, Bn03_nano2, ... | Authors: | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | Deposit date: | 2021-12-30 | Release date: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell, 185, 2022
|
|
7D2S
| Crystal structure of Rsu1/PINCH1_LIM5C complex | Descriptor: | GLYCEROL, LIM and senescent cell antigen-like-containing domain protein 1, Ras suppressor protein 1, ... | Authors: | Yang, H, Wei, Z, Cong, Y. | Deposit date: | 2020-09-17 | Release date: | 2021-02-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.653 Å) | Cite: | Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. Elife, 10, 2021
|
|
7D2U
| Crystal structure of Rsu1/PINCH1_LIM45C complex | Descriptor: | GLYCEROL, LIM and senescent cell antigen-like-containing domain protein 1, MALONATE ION, ... | Authors: | Yang, H, Wei, Z, Cong, Y. | Deposit date: | 2020-09-17 | Release date: | 2021-02-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. Elife, 10, 2021
|
|
7XCP
| Cryo-EM structure of Omicron RBD complexed with ACE2 and 304 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 304 Fab, ... | Authors: | Zhao, Z, Qi, J, Gao, F.G. | Deposit date: | 2022-03-24 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape Nat Commun, 13, 2022
|
|
7Y9Z
| Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (one-RBD-up state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | Authors: | Gao, G.F, Qi, J.X, Liu, S, Zhao, Z.N. | Deposit date: | 2022-06-26 | Release date: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape. Nat Commun, 13, 2022
|
|
7Y53
| The cryo-EM structure of human ERAD retro-translocation complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase | Authors: | Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. | Deposit date: | 2022-06-16 | Release date: | 2023-10-18 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
|
|
7Y59
| The cryo-EM structure of human ERAD retro-translocation complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Derlin-1, ... | Authors: | Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. | Deposit date: | 2022-06-16 | Release date: | 2023-10-18 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (4.51 Å) | Cite: | The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
|
|
7Y4W
| The cryo-EM structure of human ERAD retro-translocation complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase | Authors: | Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. | Deposit date: | 2022-06-16 | Release date: | 2023-10-18 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
|
|
7X9E
| Crystal structure of the 76E1 Fab in complex with a SARS-CoV-2 spike peptide | Descriptor: | 76E1 Fab Heavy Chain, 76E1 Fab Light Chain, Spike peptide | Authors: | Chen, X, Zhang, T, Ding, J, Sun, X, Sun, B. | Deposit date: | 2022-03-15 | Release date: | 2022-05-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2. Nat Microbiol, 7, 2022
|
|
7XN2
| Crystal structure of CvkR, a novel MerR-type transcriptional regulator | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Alr3614 protein, DI(HYDROXYETHYL)ETHER | Authors: | Liang, Y.J, Zhu, T, Ma, H.L, Lu, X.F, Hess, W.R. | Deposit date: | 2022-04-27 | Release date: | 2023-03-08 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | CvkR is a MerR-type transcriptional repressor of class 2 type V-K CRISPR-associated transposase systems. Nat Commun, 14, 2023
|
|
7DPM
| Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ... | Authors: | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | Deposit date: | 2020-12-20 | Release date: | 2021-02-17 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3.304 Å) | Cite: | Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV. Mabs, 13, 2021
|
|