7XCP

Cryo-EM structure of Omicron RBD complexed with ACE2 and 304 Fab

Summary for 7XCP

• Entry DOI: 10.2210/pdb7xcp/pdb
• EMDB information: 33125
• Descriptor: Processed angiotensin-converting enzyme 2, Spike protein S1, Heavy chain of 304 Fab, ... (7 entities in total)
• Functional Keywords: sars-cov-2, omicron, receptor binding domain, ace2, fab 304, viral protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 139900.80

Authors

Zhao, Z.,Qi, J.,Gao, F.G. (deposition date: 2022-03-24, release date: 2022-08-31, Last modification date: 2024-11-06)

• Primary citation: Zhao, Z.,Zhou, J.,Tian, M.,Huang, M.,Liu, S.,Xie, Y.,Han, P.,Bai, C.,Han, P.,Zheng, A.,Fu, L.,Gao, Y.,Peng, Q.,Li, Y.,Chai, Y.,Zhang, Z.,Zhao, X.,Song, H.,Qi, J.,Wang, Q.,Wang, P.,Gao, G.F.; Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape; Nat Commun, 13:4958-4958, 2022; DOI: 10.1038/s41467-022-32665-7

Experimental method

ELECTRON MICROSCOPY (3.05 Å)