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TMEM106B filaments with Fold IIb from Multiple system atrophy (case 19)
Descriptor:	Transmembrane protein 106B
Authors:	Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2022-01-25
Release date:	2022-03-09
Last modified:	2022-05-25
Method:	ELECTRON MICROSCOPY (3.47 Å)
Cite:	Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature, 605, 2022

7QVF

TMEM106B filaments with Fold I-d from Multiple system atrophy (case 18)
Descriptor:	Transmembrane protein 106B
Authors:	Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2022-01-21
Release date:	2022-03-09
Last modified:	2022-05-25
Method:	ELECTRON MICROSCOPY (3.64 Å)
Cite:	Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature, 605, 2022

7QWG

TMEM106B filaments with Fold IIa from Multiple system atrophy (case 19)
Descriptor:	Transmembrane protein 106B
Authors:	Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2022-01-25
Release date:	2022-03-09
Last modified:	2022-05-25
Method:	ELECTRON MICROSCOPY (3.38 Å)
Cite:	Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature, 605, 2022

7QVC

TMEM106B filaments with Fold I from Alzheimer's disease (case 1)
Descriptor:	Transmembrane protein 106B
Authors:	Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2022-01-21
Release date:	2022-03-09
Last modified:	2022-05-25
Method:	ELECTRON MICROSCOPY (2.64 Å)
Cite:	Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature, 605, 2022

7QWM

TMEM106B filaments with Fold III from Multiple system atrophy (case 17)
Descriptor:	Transmembrane protein 106B
Authors:	Lovestam, S, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2022-01-25
Release date:	2022-03-09
Last modified:	2022-05-25
Method:	ELECTRON MICROSCOPY (2.76 Å)
Cite:	Age-dependent formation of TMEM106B amyloid filaments in human brains. Nature, 605, 2022

1IVZ

Solution structure of the SEA domain from murine hypothetical protein homologous to human mucin 16
Descriptor:	hypothetical protein 1110008I14RIK
Authors:	Maeda, T, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:	2002-04-02
Release date:	2002-10-02
Last modified:	2023-12-27
Method:	SOLUTION NMR
Cite:	Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16) J.Biol.Chem., 279, 2004

7NCJ

Type 2AB alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1
Descriptor:	Alpha-synuclein
Authors:	Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2021-01-28
Release date:	2021-02-24
Last modified:	2024-05-01
Method:	ELECTRON MICROSCOPY (4.23 Å)
Cite:	Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021

7NCG

Type 2A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2
Descriptor:	Alpha-synuclein
Authors:	Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2021-01-28
Release date:	2021-02-24
Last modified:	2024-05-01
Method:	ELECTRON MICROSCOPY (3.43 Å)
Cite:	Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021

7NCI

Type 2B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1
Descriptor:	Alpha-synuclein
Authors:	Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2021-01-28
Release date:	2021-02-24
Last modified:	2024-05-01
Method:	ELECTRON MICROSCOPY (3.55 Å)
Cite:	Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021

7NCH

Type 1B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1
Descriptor:	Alpha-synuclein
Authors:	Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2021-01-28
Release date:	2021-02-24
Last modified:	2024-05-01
Method:	ELECTRON MICROSCOPY (3.84 Å)
Cite:	Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021

7NCK

Type 3 alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 5
Descriptor:	Alpha-synuclein
Authors:	Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2021-01-28
Release date:	2021-02-24
Last modified:	2024-05-01
Method:	ELECTRON MICROSCOPY (3.18 Å)
Cite:	Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021

7NCA

Type 1A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2
Descriptor:	Alpha-synuclein
Authors:	Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W.
Deposit date:	2021-01-28
Release date:	2021-02-24
Last modified:	2024-05-01
Method:	ELECTRON MICROSCOPY (3.47 Å)
Cite:	Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021

8OT9

CTE typeIII tau filament from Guam ALS/PDC
Descriptor:	Microtubule-associated protein tau
Authors:	Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

8OTD

TMEM106B Fold1-s filament from Guam ALS/PDC
Descriptor:	Transmembrane protein 106B
Authors:	Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Last modified:	2024-10-09
Method:	ELECTRON MICROSCOPY (2.6 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

8OTG

CTE typeI tau filament from Kii ALS/PDC
Descriptor:	Microtubule-associated protein tau
Authors:	Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Method:	ELECTRON MICROSCOPY (2.1 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

8OTH

TypeII tau filament from Kii ALS/PDC
Descriptor:	Microtubule-associated protein tau
Authors:	Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

8OTF

Ab typeII filament from Guam ALS/PDC
Descriptor:	Amyloid-beta precursor protein
Authors:	Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

8OTC

CTE typeII tau filament from Guam ALS/PDC
Descriptor:	Microtubule-associated protein tau
Authors:	Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

8OTJ

PHF tau filament from Kii ALS/PDC
Descriptor:	Microtubule-associated protein tau
Authors:	Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

8OT6

CTE typeI tau filament from Guam ALS/PDC
Descriptor:	Microtubule-associated protein tau
Authors:	Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Method:	ELECTRON MICROSCOPY (2 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

8OTE

TMEM106B Fold I-d filament from Guam ALS/PDC
Descriptor:	Transmembrane protein 106B
Authors:	Qi, C, Yang, S, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Last modified:	2024-10-16
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

8OTI

CTE typeIII tau filament
Descriptor:	Microtubule-associated protein tau
Authors:	Tetter, S, Qi, C, Ryskeldi-Falcon, B, Scheres, S.H.W, Goedert, M.
Deposit date:	2023-04-20
Release date:	2024-03-27
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc.Natl.Acad.Sci.USA, 120, 2023

1N27

Solution structure of the PWWP domain of mouse Hepatoma-derived growth factor, related protein 3
Descriptor:	Hepatoma-derived growth factor, related protein 3
Authors:	Nameki, N, Kigawa, T, Koshiba, S, Kobayashi, N, Tochio, N, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:	2002-10-22
Release date:	2003-12-23
Last modified:	2024-05-29
Method:	SOLUTION NMR
Cite:	Solution structure of the PWWP domain of the hepatoma-derived growth factor family. Protein Sci., 14, 2005

5F20

Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one
Descriptor:	3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one, Non-receptor tyrosine-protein kinase TYK2
Authors:	Skene, R.J.
Deposit date:	2015-12-01
Release date:	2016-01-13
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.91 Å)
Cite:	Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors. J.Med.Chem., 59, 2016

5F1Z

Structure of TYK2 with inhibitor 16: 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one
Descriptor:	3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one, Non-receptor tyrosine-protein kinase TYK2
Authors:	Skene, R.J.
Deposit date:	2015-12-01
Release date:	2016-01-13
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Structure-Based Design and Synthesis of 3-Amino-1,5-dihydro-4H-pyrazolopyridin-4-one Derivatives as Tyrosine Kinase 2 Inhibitors. J.Med.Chem., 59, 2016

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Displayed results:	25
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