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Cryo-EM structure of the sarilumab Fab/IL-6R complex
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Sarilumab Fab, Interleukin-6 receptor subunit alpha, ...
Authors:	She, J, Chen, L, Wang, M.X.
Deposit date:	2023-03-13
Release date:	2024-03-20
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Cryo-EM structure of the sarilumab Fab/IL-6R complex To Be Published

Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies
Descriptor:	CAMP-dependent protein kinase, alpha-catalytic subunit, N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE, ...
Authors:	Murray, J.M.
Deposit date:	2006-04-28
Release date:	2007-05-01
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies Bioorg.Med.Chem.Lett., 16, 2006

Cryo-EM structure of the Tocilizumab Fab/IL-6R complex
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Tocilizumab Fab, IL6R-D2 peptide, ...
Authors:	She, J, Chen, L.
Deposit date:	2023-04-25
Release date:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Cryo-EM structures of tocilizumab and sarilumab Fabs in complex with IL-6R To Be Published