7A3W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7a3w by Molmil](/molmil-images/mine/7a3w) | Structure of Imine Reductase from Pseudomonas sp. | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, NAD(P)-dependent oxidoreductase, ... | Authors: | Cuetos, A, Thorpe, T, Turner, N.J, Grogan, G. | Deposit date: | 2020-08-18 | Release date: | 2021-08-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Multifunctional biocatalyst for conjugate reduction and reductive amination. Nature, 604, 2022
|
|
6H7P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6h7p by Molmil](/molmil-images/mine/6h7p) | Reductive Aminase from Aspergillus terreus in complex with NADPH4, cyclohexanone and allyl amine | Descriptor: | CYCLOHEXANONE, Reductive Aminase, [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate, ... | Authors: | Sharma, M, Grogan, G, Mangas-Sanchez, J, Turner, N.J. | Deposit date: | 2018-07-31 | Release date: | 2019-04-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure of Reductive Aminase from Aspergillus terreus Acs Catalysis, 2018
|
|
5A9R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5a9r by Molmil](/molmil-images/mine/5a9r) | Apo form of Imine reductase from Amycolatopsis orientalis | Descriptor: | ACETATE ION, IMINE REDUCTASE | Authors: | Man, H, Aleku, G, Turner, N.J, Grogan, G. | Deposit date: | 2015-07-22 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Stereoselectivity and Structural Characterization of an Imine Reductase (Ired) from Amycolatopsis Orientalis Acs Catalysis, 6, 2016
|
|
6SLE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sle by Molmil](/molmil-images/mine/6sle) | Structure of Reductive Aminase from Neosartorya fumigata in complex with NADP+ | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, putative | Authors: | Sharma, M, Mangas-Sanchez, J, Turner, N.J, Grogan, G. | Deposit date: | 2019-08-19 | Release date: | 2020-06-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases. Chem Sci, 11, 2020
|
|
6SKX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6skx by Molmil](/molmil-images/mine/6skx) | Structure of Reductive Aminase from Neosartorya fumigata | Descriptor: | Oxidoreductase, putative | Authors: | Sharma, M, Mangas-Sanchez, J, Turner, N.J, Grogan, G. | Deposit date: | 2019-08-16 | Release date: | 2020-06-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases. Chem Sci, 11, 2020
|
|
2WQ8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wq8 by Molmil](/molmil-images/mine/2wq8) | Glycan labelling using engineered variants of galactose oxidase obtained by directed evolution | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CALCIUM ION, ... | Authors: | Rannes, J.G, Ioannou, A, Willies, S.C, Behrens, C, Grogan, G.J, Flitsch, S.L, Turner, N.J. | Deposit date: | 2009-08-14 | Release date: | 2010-09-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Glycoprotein Labeling Using Engineered Variants of Galactose Oxidase Obtained by Directed Evolution. J.Am.Chem.Soc., 133, 2011
|
|
5FWN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5fwn by Molmil](/molmil-images/mine/5fwn) | Imine Reductase from Amycolatopsis orientalis. Closed form in in complex with (R)- Methyltetrahydroisoquinoline | Descriptor: | (1R)-1-methyl-1,2,3,4-tetrahydroisoquinoline, IMINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Man, H, Aleku, G, Turner, N.J, Grogan, G. | Deposit date: | 2016-02-18 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Stereoselectivity and Structural Characterization of an Imine Reductase (Ired) from Amycolatopsis Orientalis Acs Catalysis, 6, 2016
|
|
5G2P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5g2p by Molmil](/molmil-images/mine/5g2p) | The crystal structure of a S-selective transaminase from Arthrobacter sp. | Descriptor: | CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, TRANSAMINASE | Authors: | van Oosterwijk, N, Willies, S, Hekelaar, J, Terwisscha van Scheltinga, A.C, Turner, N.J, Dijkstra, B.W. | Deposit date: | 2016-04-12 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural Basis of Substrate Range and Enantioselectivity of Two S-Selective Omega- Transaminases Biochemistry, 55, 2016
|
|
5G6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5g6s by Molmil](/molmil-images/mine/5g6s) | Imine reductase from Aspergillus oryzae in complex with NADP(H) and (R)-rasagiline | Descriptor: | IMINE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RASAGILINE | Authors: | Man, H, Aleku, G, Turner, N.J, Grogan, G. | Deposit date: | 2016-06-23 | Release date: | 2017-05-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A reductive aminase from Aspergillus oryzae. Nat Chem, 9, 2017
|
|
5G6R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5g6r by Molmil](/molmil-images/mine/5g6r) | Imine reductase from Aspergillus oryzae | Descriptor: | IMINE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Man, H, Aleku, G, Turner, N.J, Grogan, G. | Deposit date: | 2016-06-23 | Release date: | 2017-05-31 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | A reductive aminase from Aspergillus oryzae. Nat Chem, 9, 2017
|
|
5G2Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5g2q by Molmil](/molmil-images/mine/5g2q) | The crystal structure of a S-selective transaminase from Arthrobacter sp. with alanine bound | Descriptor: | 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-PROPIONIC ACID, TRANSAMINASE | Authors: | van Oosterwijk, N, Willies, S, Hekelaar, J, Terwisscha van Scheltinga, A.C, Turner, N.J, Dijkstra, B.W. | Deposit date: | 2016-04-12 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis of Substrate Range and Enantioselectivity of Two S-Selective Omega- Transaminases Biochemistry, 55, 2016
|
|
5G0A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5g0a by Molmil](/molmil-images/mine/5g0a) | The crystal structure of a S-selective transaminase from Bacillus megaterium | Descriptor: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | van Oosterwijk, N, Willies, S, Hekelaar, J, Terwisscha van Scheltinga, A.C, Turner, N.J, Dijkstra, B.W. | Deposit date: | 2016-03-17 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Basis of Substrate Range and Enantioselectivity of Two S-Selective Omega- Transaminases Biochemistry, 55, 2016
|
|
5G09
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5g09 by Molmil](/molmil-images/mine/5g09) | The crystal structure of a S-selective transaminase from Bacillus megaterium bound with R-alpha-methylbenzylamine | Descriptor: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... | Authors: | van Oosterwijk, N, Willies, S, Hekelaar, J, Terwisscha van Scheltinga, A.C, Turner, N.J, Dijkstra, B.W. | Deposit date: | 2016-03-17 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis of Substrate Range and Enantioselectivity of Two S-Selective Omega- Transaminases Biochemistry, 55, 2016
|
|
5A9S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5a9s by Molmil](/molmil-images/mine/5a9s) | NADPH complex of Imine Reductase from Amycolatopsis orientalis | Descriptor: | CALCIUM ION, IMINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Man, H, Aleku, G, Turner, N.J, Grogan, G. | Deposit date: | 2015-07-22 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis Acs Catalysis, 6, 2016
|
|
5A9T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5a9t by Molmil](/molmil-images/mine/5a9t) | Imine Reductase from Amycolatopsis orientalis in complex with (R)- Methyltetrahydroisoquinoline | Descriptor: | (1R)-1-methyl-1,2,3,4-tetrahydroisoquinoline, ACETATE ION, CALCIUM ION, ... | Authors: | Man, H, Aleku, G, Turner, N.J, Grogan, G. | Deposit date: | 2015-07-22 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Stereoselectivity and Structural Characterization of an Imine Reductase (Ired) from Amycolatopsis Orientalis Acs Catalysis, 6, 2016
|
|
3ZDN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3zdn by Molmil](/molmil-images/mine/3zdn) | D11-C mutant of monoamine oxidase from Aspergillus niger | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, MONOAMINE OXIDASE N | Authors: | Frank, A, Ghislieri, D, Willies, S, Turner, N.J, Grogan, G. | Deposit date: | 2012-11-29 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products. J.Am.Chem.Soc., 135, 2013
|
|
6EOH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eoh by Molmil](/molmil-images/mine/6eoh) | Reductive Aminase from Aspergillus terreus in complex with NADPH and ethyl levulinate | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Reductive Aminase, ethyl levulinate | Authors: | Sharma, M, Grogan, G, Mangas-Sanchez, J, Turner, N.J. | Deposit date: | 2017-10-09 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases Acs Catalysis, 2018
|
|
6EOD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eod by Molmil](/molmil-images/mine/6eod) | |
6EOI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eoi by Molmil](/molmil-images/mine/6eoi) | Reductive Aminase from Aspergillus terreus in complex with NADPH and ethyl-5-oxohexanoate | Descriptor: | MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Reductive Aminase, ... | Authors: | Sharma, M, Mangas-Sanchez, J, Turner, N.J, Grogan, G. | Deposit date: | 2017-10-09 | Release date: | 2018-10-31 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases Acs Catalysis, 2018
|
|
5LOC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5loc by Molmil](/molmil-images/mine/5loc) | |
7OSN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7osn by Molmil](/molmil-images/mine/7osn) | IRED361 from Micromonospora sp. in complex with NADP+ | Descriptor: | 6-phosphogluconate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Gilio, A.K, Harawa, V, Turner, N, Grogan, G.J. | Deposit date: | 2021-06-09 | Release date: | 2022-06-22 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Synthesis of Stereoenriched Piperidines via Chemo-Enzymatic Dearomatization of Activated Pyridines. J.Am.Chem.Soc., 144, 2022
|
|
5OJL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ojl by Molmil](/molmil-images/mine/5ojl) | Imine Reductase from Aspergillus terreus in complex with NADPH4 and dibenz[c,e]azepine | Descriptor: | 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE, 5-methyl-7~{H}-benzo[d][2]benzazepine, Imine reductase | Authors: | Sharma, M, Grogan, G. | Deposit date: | 2017-07-21 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines. Angew. Chem. Int. Ed. Engl., 56, 2017
|
|
4D3D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4d3d by Molmil](/molmil-images/mine/4d3d) | Structure of Imine Reductase BcSIRED from Bacillus cereus BAG3X2 | Descriptor: | IMINE REDUCTASE, MAGNESIUM ION, O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL | Authors: | Man, H, Hart, S, Turkenburg, J.P, Grogan, G. | Deposit date: | 2014-10-21 | Release date: | 2015-04-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structure, Activity and Stereoselectivity of Nadph-Dependent Oxidoreductases Catalysing the S-Selective Reduction of the Imine Substrate 2-Methylpyrroline. Chembiochem, 16, 2015
|
|
4D3F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4d3f by Molmil](/molmil-images/mine/4d3f) | BcSIRED from Bacillus cereus in complex with NADPH | Descriptor: | IMINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Man, H, Hart, S, Turkenburg, J.P, Grogan, G. | Deposit date: | 2014-10-21 | Release date: | 2015-04-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structure, Activity and Stereoselectivity of Nadph-Dependent Oxidoreductases Catalysing the S-Selective Reduction of the Imine Substrate 2-Methylpyrroline. Chembiochem, 16, 2015
|
|
2VVM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vvm by Molmil](/molmil-images/mine/2vvm) | The structure of MAO-N-D5, a variant of monoamine oxidase from Aspergillus niger. | Descriptor: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, MONOAMINE OXIDASE N, ... | Authors: | Atkin, K.E, Hart, S, Turkenburg, J.P, Brzozowski, A.M, Grogan, G.J. | Deposit date: | 2008-06-10 | Release date: | 2008-11-04 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The Structure of Monoamine Oxidase from Aspergillus Niger Provides a Molecular Context for Improvements in Activity Obtained by Directed Evolution. J.Mol.Biol., 384, 2008
|
|