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5VOE
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BU of 5voe by Molmil
DesGla-XaS195A Bound to Aptamer 11F7t
Descriptor: Aptamer 11F7t (36-MER), CALCIUM ION, Coagulation factor X, ...
Authors:Gunaratne, R, Kumar, S, Frederiksen, J.W, Stayrook, S, Lohrmann, J.L, Perry, K, Chabata, C.V, Thalji, N.K, Ho, M.D, Arepally, G, Camire, R.M, Krishnaswamy, S.K, Sullenger, B.A.
Deposit date:2017-05-02
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass.
Nat. Biotechnol., 36, 2018
3DD2
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BU of 3dd2 by Molmil
Crystal structure of an RNA aptamer bound to human thrombin
Descriptor: ACETIC ACID, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, DI(HYDROXYETHYL)ETHER, ...
Authors:Long, S.B, Sullenger, B.A.
Deposit date:2008-06-04
Release date:2008-11-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of an RNA aptamer bound to thrombin.
Rna, 14, 2008
8TQS
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BU of 8tqs by Molmil
Complex of human thrombin (S195A) bound to a bivalent inhibitor comprised of DNA Aptamer HD22 conjugated to Dabigatran with a linker.
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (30-MER), ...
Authors:Krishnaswamy, S, Kumar, S.
Deposit date:2023-08-08
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.207 Å)
Cite:Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors.
Nat Commun, 15, 2024
5VOF
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BU of 5vof by Molmil
DesGla-XaS195A Bound to Aptamer 11F7t and Rivaroxaban
Descriptor: 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, CALCIUM ION, Coagulation factor X, ...
Authors:Krishnaswamy, S, Kumar, S.
Deposit date:2017-05-02
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass.
Nat. Biotechnol., 36, 2018
8EPC
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BU of 8epc by Molmil
Crystal structure of human coagulation factor IXa (S195A), apo-form
Descriptor: CALCIUM ION, Coagulation factor IXa heavy chain, Coagulation factor IXa light chain
Authors:Kolyadko, V.N, Krishnaswamy, S.
Deposit date:2022-10-05
Release date:2024-07-03
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Allosteric Control of Coagulation Factor IXa via Its Exosite II Regulates Blood Clotting
Proc.Natl.Acad.Sci.USA, 2024
8EPH
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BU of 8eph by Molmil
Crystal structure of human coagulation factor IXa (S195A), apo-form, DES-GLA
Descriptor: CALCIUM ION, Coagulation factor IXa heavy chain, Coagulation factor IXa light chain, ...
Authors:Kolyadko, V.N, Krishnaswamy, S.
Deposit date:2022-10-05
Release date:2024-07-03
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Allosteric Control of Coagulation Factor IXa via Its Exosite II Regulates Blood Clotting
Proc.Natl.Acad.Sci.USA, 2024
8EPK
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BU of 8epk by Molmil
Complex of anticoagulant RNA aptamer and human coagulation factor IXa (S195A)
Descriptor: CALCIUM ION, Coagulation factor IXa heavy chain, Coagulation factor IXa light chain, ...
Authors:Kolyadko, V.N, Krishnaswamy, S.
Deposit date:2022-10-05
Release date:2024-07-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Allosteric Control of Coagulation Factor IXa via Its Exosite II Regulates Blood Clotting
Proc.Natl.Acad.Sci.USA, 2024

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数据于2024-07-17公开中

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