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3ZI5
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BU of 3zi5 by Molmil
Crystal STRUCTURE OF RESTRICTION ENDONUCLEASE BFII C-TERMINAL RECOGNITION DOMAIN IN COMPLEX WITH COGNATE DNA
Descriptor: 5'-D(*AP*GP*CP*AP*CP*TP*GP*GP*GP*TP*CP*GP)-3', 5'-D(*CP*GP*AP*CP*CP*CP*AP*GP*TP*GP*CP*TP)-3', RESTRICTION ENDONUCLEASE
Authors:Golovenko, D, Manakova, E, Zakrys, L, Zaremba, M, Sasnauskas, G, Grazulis, S, Siksnys, V.
Deposit date:2013-01-03
Release date:2014-01-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insight Into the Specificity of the B3 DNA-Binding Domains Provided by the Co-Crystal Structure of the C-Terminal Fragment of Bfii Restriction Enzyme
Nucleic Acids Res., 42, 2014
3BM3
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BU of 3bm3 by Molmil
Restriction endonuclease PspGI-substrate DNA complex
Descriptor: CITRIC ACID, DNA (5'-D(*CP*AP*TP*CP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*CP*CP*TP*GP*GP*AP*T)-3'), ...
Authors:Szczepanowski, R.H, Carpenter, M, Czapinska, H, Tamulaitis, G, Siksnys, V, Bhagwat, A, Bochtler, M.
Deposit date:2007-12-12
Release date:2008-09-16
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A direct crystallographic demonstration that Type II restriction endonuclease PspGI flips nucleotides
To be Published
2IXS
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BU of 2ixs by Molmil
Structure of SdaI restriction endonuclease
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SDAI RESTRICTION ENDONUCLEASE, ...
Authors:Tamulaitiene, G, Jakubauskas, A, Urbanke, C, Huber, R, Grazulis, S, Siksnys, V.
Deposit date:2006-07-11
Release date:2006-09-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of the Rare-Cutting Restriction Enzyme Sdai Reveals Unexpected Domain Architecture
Structure, 14, 2006
4ABT
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BU of 4abt by Molmil
Crystal structure of Type IIF restriction endonuclease NgoMIV with cognate uncleaved DNA
Descriptor: 5'-D(*TP*GP*CP*GP*CP*CP*GP*GP*CP*GP*CP)-3', CALCIUM ION, TYPE-2 RESTRICTION ENZYME NGOMIV
Authors:Manakova, E.N, Grazulis, S, Zaremba, M, Tamulaitiene, G, Golovenko, D, Siksnys, V.
Deposit date:2011-12-11
Release date:2011-12-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structure of Type Iif Restriction Endonuclease Ngomiv with Cognate Uncleaved DNA
To be Published
3IMB
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BU of 3imb by Molmil
Alternative binding mode of restriction endonuclease BcnI to cognate DNA
Descriptor: 5'-D(*CP*GP*CP*CP*CP*GP*GP*AP*C)-3', 5'-D(*GP*TP*CP*CP*GP*GP*GP*CP*G)-3', R.BcnI
Authors:Sokolowska, M, Kaus-Drobek, M, Czapinska, H, Tamulaitis, G, Szczepanowski, R.H, Siksnys, V, Bochtler, M.
Deposit date:2009-08-10
Release date:2010-08-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:How BcnI and MvaI distinguish W from S
To be Published
8PM4
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BU of 8pm4 by Molmil
Cryo-EM structure of the Cas12m-crRNA-target DNA complex
Descriptor: DNA oligoduplex, non-target strand, chain D, ...
Authors:Sasnauskas, G, Tamulaitiene, G, Karvelis, T, Bigelyte, G, Siksnys, V.
Deposit date:2023-06-28
Release date:2024-02-07
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing.
Nucleic Acids Res., 52, 2024
1KNV
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BU of 1knv by Molmil
Bse634I restriction endonuclease
Descriptor: ACETATE ION, Bse634I restriction endonuclease, CHLORIDE ION
Authors:Grazulis, S, Deibert, M, Rimseliene, R, Skirgaila, R, Sasnauskas, G, Lagunavicius, A, Repin, V, Urbanke, C, Huber, R, Siksnys, V.
Deposit date:2001-12-19
Release date:2002-02-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence.
Nucleic Acids Res., 30, 2002
4RZL
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BU of 4rzl by Molmil
DNA recognition domain of the cytosine modification-dependent restriction endonuclease LpnPI
Descriptor: PENTAETHYLENE GLYCOL, Restriction endonuclease LpnPI
Authors:Sasnauskas, G, Tamulaitiene, G, Siksnys, V.
Deposit date:2014-12-22
Release date:2015-06-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-guided sequence specificity engineering of the modification-dependent restriction endonuclease LpnPI.
Nucleic Acids Res., 43, 2015
2FQZ
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BU of 2fqz by Molmil
Metal-depleted Ecl18kI in complex with uncleaved DNA
Descriptor: DNA STRAND 1, DNA STRAND 2, R.Ecl18kI
Authors:Bochtler, M, Szczepanowski, R.H, Tamulaitis, G, Grazulis, S, Czapinska, H, Manakova, E, Siksnys, V.
Deposit date:2006-01-18
Release date:2006-06-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nucleotide flips determine the specificity of the Ecl18kI restriction endonuclease
Embo J., 25, 2006
2GB7
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BU of 2gb7 by Molmil
Metal-depleted Ecl18kI in complex with uncleaved, modified DNA
Descriptor: DNA STRAND 1, DNA STRAND 2, R.Ecl18kI
Authors:Bochtler, M, Szczepanowski, R.H, Tamulaitis, G, Grazulis, S, Czapinska, H, Manakova, E, Siksnys, V.
Deposit date:2006-03-10
Release date:2006-06-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nucleotide flips determine the specificity of the Ecl18kI restriction endonuclease
Embo J., 25, 2006
4RCT
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BU of 4rct by Molmil
Crystal structure of R-protein of NgoAVII restriction endonuclease
Descriptor: Restriction endonuclease R.NgoVII
Authors:Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V.
Deposit date:2014-09-17
Release date:2014-12-24
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Nucleic Acids Res., 42, 2014
4RD5
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BU of 4rd5 by Molmil
Crystal structure of R.NgoAVII restriction endonuclease B3 domain with cognate DNA
Descriptor: DNA (5'-D(*CP*CP*CP*TP*AP*AP*GP*CP*GP*GP*CP*AP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*AP*TP*TP*GP*CP*CP*GP*CP*TP*TP*AP*GP*G)-3'), Restriction endonuclease R.NgoVII
Authors:Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V.
Deposit date:2014-09-18
Release date:2014-12-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Nucleic Acids Res., 42, 2014
4RDM
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BU of 4rdm by Molmil
Crystal structure of R.NgoAVII restriction endonuclease B3 domain with cognate DNA
Descriptor: DNA (5'-D(*CP*CP*TP*AP*AP*GP*CP*GP*GP*CP*AP*AP*TP*CP*C)-3)', DNA (5'-D(*GP*GP*GP*AP*TP*TP*GP*CP*CP*GP*CP*TP*TP*AP*G)-3)', Restriction endonuclease R.NgoVII, ...
Authors:Tamulaitiene, G, Silanskas, A, Grazulis, S, Zaremba, M, Siksnys, V.
Deposit date:2014-09-19
Release date:2014-12-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the R-protein of the multisubunit ATP-dependent restriction endonuclease NgoAVII.
Nucleic Acids Res., 42, 2014
8EXA
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BU of 8exa by Molmil
ISDra2 TnpB in complex with reRNA and cognate DNA, conformation 1 (RuvC domain resolved)
Descriptor: DNA (43-MER), RNA (150-MER), RNA-guided DNA endonuclease TnpB
Authors:Sasnauskas, G, Tamulaitiene, G, Carabias, A, Karvelis, T, Druteika, G, Silanskas, A, Montoya, G, Venclovas, C, Kazlauskas, D, Siksnys, V.
Deposit date:2022-10-25
Release date:2023-04-05
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:TnpB structure reveals minimal functional core of Cas12 nuclease family.
Nature, 616, 2023
8EX9
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BU of 8ex9 by Molmil
ISDra2 TnpB in complex with reRNA and cognate DNA, conformation 2 (RuvC domain unresolved)
Descriptor: DNA (43-MER), RNA (150-MER), RNA-guided DNA endonuclease TnpB
Authors:Sasnauskas, G, Tamulaitiene, G, Carabias, A, Karvelis, T, Druteika, G, Silanskas, A, Montoya, G, Venclovas, C, Kazlauskas, D, Siksnys, V.
Deposit date:2022-10-25
Release date:2023-04-05
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:TnpB structure reveals minimal functional core of Cas12 nuclease family.
Nature, 616, 2023
4ZSF
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BU of 4zsf by Molmil
Crystal structure of pre-specific restriction endonuclease BsaWI-DNA complex
Descriptor: BsaWI endonuclease, CALCIUM ION, DNA, ...
Authors:Tamulaitiene, G, Rutkauskas, M, Grazulis, S, Siksnys, V.
Deposit date:2015-05-13
Release date:2015-10-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Functional significance of protein assemblies predicted by the crystal structure of the restriction endonuclease BsaWI.
Nucleic Acids Res., 43, 2015
4QDL
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BU of 4qdl by Molmil
Crystal structure of E.coli Cas1-Cas2 complex
Descriptor: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2
Authors:Tamulaitiene, G, Sinkunas, T, Silanskas, A, Gasiunas, G, Grazulis, S, Siksnys, V.
Deposit date:2014-05-14
Release date:2014-05-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of E.coli Cas1-Cas2 complex
To be Published
6GHC
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BU of 6ghc by Molmil
Modification dependent EcoKMcrA restriction endonuclease
Descriptor: 5-methylcytosine-specific restriction enzyme A, ZINC ION
Authors:Czapinska, H, Kowalska, M, Zagorskaite, E, Manakova, E, Xu, S, Siksnys, V, Sasnauskas, G, Bochtler, M.
Deposit date:2018-05-07
Release date:2018-08-08
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Activity and structure of EcoKMcrA.
Nucleic Acids Res., 46, 2018
1FIU
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BU of 1fiu by Molmil
TETRAMERIC RESTRICTION ENDONUCLEASE NGOMIV IN COMPLEX WITH CLEAVED DNA
Descriptor: ACETIC ACID, DNA (5'-D(*TP*GP*CP*G)-3'), DNA (5'-D(P*CP*CP*GP*GP*CP*GP*C)-3'), ...
Authors:Deibert, M, Grazulis, S, Sasnauskas, G, Siksnys, V, Huber, R.
Deposit date:2000-08-07
Release date:2001-02-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the tetrameric restriction endonuclease NgoMIV in complex with cleaved DNA.
Nat.Struct.Biol., 7, 2000
2C1L
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BU of 2c1l by Molmil
Structure of the BfiI restriction endonuclease
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICARBONATE ION, ...
Authors:Grazulis, S, Manakova, E, Roessle, M, Bochtler, M, Tamulaitiene, G, Huber, R, Siksnys, V.
Deposit date:2005-09-15
Release date:2005-10-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Metal-Independent Restriction Enzyme Bfii Reveals Fusion of a Specific DNA-Binding Domain with a Nonspecific Nuclease.
Proc.Natl.Acad.Sci.USA, 102, 2005
2OAA
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BU of 2oaa by Molmil
Restriction endonuclease MvaI-cognate DNA substrate complex
Descriptor: 5'-D(*CP*AP*TP*CP*CP*AP*GP*GP*TP*AP*C)-3', 5'-D(*GP*GP*TP*AP*CP*CP*TP*GP*GP*AP*T)-3', CALCIUM ION, ...
Authors:Kaus-Drobek, M, Czapinska, H, Sokolowska, M, Tamulaitis, G, Szczepanowski, R.H, Urbanke, K, Siksnys, V, Bochtler, M.
Deposit date:2006-12-15
Release date:2007-02-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Restriction endonuclease MvaI is a monomer that recognizes its target sequence asymmetrically.
Nucleic Acids Res., 35, 2007
2Q10
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BU of 2q10 by Molmil
RESTRICTION ENDONUCLEASE BcnI (WILD TYPE)-COGNATE DNA SUBSTRATE COMPLEX
Descriptor: CALCIUM ION, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*CP*CP*GP*GP*AP*GP*AP*C)-3'), ...
Authors:Sokolowska, M, Kaus-Drobek, M, Czapinska, H, Tamulaitis, G, Szczepanowski, R.H, Urbanke, C, Siksnys, V, Bochtler, M.
Deposit date:2007-05-23
Release date:2007-06-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Monomeric Restriction Endonuclease BcnI in the Apo Form and in an Asymmetric Complex with Target DNA.
J.Mol.Biol., 369, 2007
2ODH
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BU of 2odh by Molmil
Restriction Endonuclease BCNI in the Absence of DNA
Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, R.BcnI
Authors:Sokolowska, M, Kaus-Drobek, M, Czapinska, H, Tamulaitis, G, Szczepanowski, R.H, Urbanke, K, Siksnys, V, Bochtler, M.
Deposit date:2006-12-22
Release date:2007-03-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Monomeric restriction endonuclease BcnI in the apo form and in an asymmetric complex with target DNA.
J.Mol.Biol., 369, 2007
2ODI
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BU of 2odi by Molmil
Restriction Endonuclease BCNI-Cognate DNA Substrate Complex
Descriptor: 5'-D(*AP*AP*CP*CP*CP*GP*GP*AP*GP*AP*C)-3', 5'-D(*CP*TP*CP*CP*GP*GP*GP*TP*TP*GP*T)-3', CALCIUM ION, ...
Authors:Sokolowska, M, Kaus-Drobek, M, Czapinska, H, Tamulaitis, G, Szczepanowski, R.H, Urbanke, C, Siksnys, V, Bochtler, M.
Deposit date:2006-12-22
Release date:2007-03-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Monomeric restriction endonuclease BcnI in the apo form and in an asymmetric complex with target DNA.
J.Mol.Biol., 369, 2007
2OA9
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BU of 2oa9 by Molmil
Restriction endonuclease MvaI in the absence of DNA
Descriptor: ACETATE ION, CADMIUM ION, CHLORIDE ION, ...
Authors:Kaus-Drobek, M, Czapinska, H, Sokolowska, M, Tamulaitis, G, Szczepanowski, R.H, Urbanke, K, Siksnys, V, Bochtler, M.
Deposit date:2006-12-15
Release date:2007-02-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Restriction endonuclease MvaI is a monomer that recognizes its target sequence asymmetrically.
Nucleic Acids Res., 35, 2007

 

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