6XZ2
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7OOZ
| Purine nucleoside phosphorylase(DeoD-type) from H. pylori with 6-benzyloxo-2-chloropurine | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-benzyloxo-2-chloropurine, GLYCEROL, ... | Authors: | Narczyk, M, Stefanic, Z. | Deposit date: | 2021-05-28 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium. J Enzyme Inhib Med Chem, 37, 2022
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7OP9
| Purine nucleoside phosphorylase(DeoD-type) from H. pylori with 2,6-dichloropurine | Descriptor: | 2,6-bis(chloranyl)-7H-purine, IMIDAZOLE, MAGNESIUM ION, ... | Authors: | Narczyk, M, Stefanic, Z. | Deposit date: | 2021-05-31 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium. J Enzyme Inhib Med Chem, 37, 2022
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7OPA
| Purine nucleoside phosphorylase(DeoD-type) from H. pylori with 6-benzylthiopurine | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-benzylthio-2-chloropurine, GLYCEROL, ... | Authors: | Narczyk, M, Stefanic, Z. | Deposit date: | 2021-05-31 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium. J Enzyme Inhib Med Chem, 37, 2022
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7OOY
| Purine nucleoside phosphorylase(DeoD-type) from H. pylori with 6-benzylthio-2-chloropurine | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-benzylthio-2-chloropurine, GLYCEROL, ... | Authors: | Narczyk, M, Stefanic, Z. | Deposit date: | 2021-05-28 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium. J Enzyme Inhib Med Chem, 37, 2022
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7PVO
| Adenylosuccinate Synthetase from H. pylori in complex with IMP | Descriptor: | Adenylosuccinate synthetase, INOSINIC ACID, SULFATE ION | Authors: | Narczyk, M, Bzowska, A, Maksymiuk, W. | Deposit date: | 2021-10-05 | Release date: | 2022-11-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site. Int.J.Biol.Macromol., 226, 2023
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8QWA
| Adenylosuccinate Synthetase from H. pylori in complex with PLP and IMP | Descriptor: | Adenylosuccinate synthetase, GLYCEROL, INOSINIC ACID, ... | Authors: | Bzowska, A, Narczyk, M, Maksymiuk, W. | Deposit date: | 2023-10-19 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Vitamin B6 inhibits activity of Helicobacter pylori adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant H. pylori strains. J Enzyme Inhib Med Chem, 39, 2024
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3FUC
| Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit | Descriptor: | AZIDE ION, MAGNESIUM ION, Purine nucleoside phosphorylase, ... | Authors: | Bochtler, M, Breer, K, Bzowska, A, Chojnowski, G, Hashimoto, M, Hikishima, S, Narczyk, M, Wielgus-Kutrowska, B, Yokomatsu, T. | Deposit date: | 2009-01-14 | Release date: | 2009-12-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | 1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state. Biochem.Biophys.Res.Commun., 391, 2010
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5LU0
| Crystal structure of H. pylori referent strain in complex with PO4 | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, ... | Authors: | Stefanic, Z. | Deposit date: | 2016-09-07 | Release date: | 2017-09-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features. FEBS J., 285, 2018
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6F52
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6F4W
| Crystal structure of H. pylori purine nucleoside phosphorylase in complex with formycin A | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, Purine nucleoside phosphorylase DeoD-type | Authors: | Stefanic, Z. | Deposit date: | 2017-11-30 | Release date: | 2018-02-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.293 Å) | Cite: | Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features. FEBS J., 285, 2018
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6F5I
| Crystal structure of H. pylori purine nucleoside phosphorylase | Descriptor: | METHANOL, Purine nucleoside phosphorylase DeoD-type | Authors: | Stefanic, Z. | Deposit date: | 2017-12-01 | Release date: | 2018-02-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features. FEBS J., 285, 2018
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6F5A
| Crystal structure of H. pylori purine nucleoside phosphorylase | Descriptor: | Purine nucleoside phosphorylase DeoD-type | Authors: | Stefanic, Z. | Deposit date: | 2017-12-01 | Release date: | 2018-02-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features. FEBS J., 285, 2018
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6F4X
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7T7H
| Crystal structure of Vaccinia Virus decapping enzyme D9 in complex with inhibitor CP100356 | Descriptor: | 4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine, DNA repair NTP-phosphohydrolase, SODIUM ION | Authors: | Peters, J.K, Gross, J.D. | Deposit date: | 2021-12-15 | Release date: | 2022-06-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.78000259 Å) | Cite: | Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9. Acs Chem.Biol., 17, 2022
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6ZXQ
| Adenylosuccinate Synthetase from H. pylori in complex with HDA, GDP, IMO, Mg | Descriptor: | 6-O-PHOSPHORYL INOSINE MONOPHOSPHATE, Adenylosuccinate synthetase, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Bubic, A, Stefanic, Z. | Deposit date: | 2020-07-30 | Release date: | 2021-08-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site Int.J.Biol.Macromol., 2023
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3UT6
| Crystal structure of E. Coli PNP complexed with PO4 and formycin A | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, PHOSPHATE ION, Purine nucleoside phosphorylase deoD-type | Authors: | Stefanic, Z. | Deposit date: | 2011-11-25 | Release date: | 2012-05-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.895 Å) | Cite: | New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A. Febs Lett., 586, 2012
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3OOH
| Crystal structure of E. Coli purine nucleoside phosphorylase with PO4 | Descriptor: | PHOSPHATE ION, Purine nucleoside phosphorylase deoD-type | Authors: | Mikleusevic, G, Stefanic, Z, Narzyk, M, Wielgus-Kutrowska, B, Bzowska, A, Luic, M. | Deposit date: | 2010-08-31 | Release date: | 2011-07-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies. Biochimie, 93, 2011
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3ONV
| Crystal structure of E. Coli purine nucleoside phosphorylase with SO4 | Descriptor: | Purine nucleoside phosphorylase deoD-type, SULFATE ION | Authors: | Mikleusevic, G, Stefanic, Z, Narzyk, M, Wielgus-Kutrowska, B, Bzowska, A, Luic, M. | Deposit date: | 2010-08-30 | Release date: | 2011-07-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies. Biochimie, 93, 2011
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3OPV
| Crystal structure of E. Coli purine nucleoside phosphorylase Arg24Ala mutant | Descriptor: | PHOSPHATE ION, Purine nucleoside phosphorylase deoD-type | Authors: | Mikleusevic, G, Stefanic, Z, Narzyk, M, Wielgus-Kutrowska, B, Bzowska, A, Luic, M. | Deposit date: | 2010-09-02 | Release date: | 2011-07-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies. Biochimie, 93, 2011
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3OOE
| Crystal structure of E. Coli purine nucleoside phosphorylase with PO4 | Descriptor: | PHOSPHATE ION, Purine nucleoside phosphorylase deoD-type | Authors: | Mikleusevic, G, Stefanic, Z, Narzyk, M, Wielgus-Kutrowska, B, Bzowska, A, Luic, M. | Deposit date: | 2010-08-31 | Release date: | 2011-07-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies. Biochimie, 93, 2011
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4TS9
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4TTJ
| Crystal structure of double mutant E. Coli purine nucleoside phosphorylase with 6 FMC molecules | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, PHOSPHATE ION, Purine nucleoside phosphorylase DeoD-type, ... | Authors: | Stefanic, Z, Bzowska, A. | Deposit date: | 2014-06-21 | Release date: | 2015-07-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.874 Å) | Cite: | Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis. Sci Rep, 8, 2018
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4TTA
| Crystal structure of double mutant E. Coli purine nucleoside phosphorylase with 2 FMC molecules | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, PHOSPHATE ION, Purine nucleoside phosphorylase DeoD-type, ... | Authors: | Stefanic, Z, Bzowska, A. | Deposit date: | 2014-06-20 | Release date: | 2015-07-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis. Sci Rep, 8, 2018
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4TTI
| Crystal structure of double mutant E. Coli purine nucleoside phosphorylase with 4 FMC molecules | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, PHOSPHATE ION, Purine nucleoside phosphorylase DeoD-type, ... | Authors: | Stefanic, Z, Bzowska, A. | Deposit date: | 2014-06-21 | Release date: | 2015-07-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis. Sci Rep, 8, 2018
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