9E19
 
 | | Structure of RyR1 in the open state in the presence of pentoxifylline | | Descriptor: | 3,7-DIMETHYL-1-(5-OXOHEXYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.04 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E1G
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9E1H
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9E1E
 | | Structure of RyR1 in the primed state in the presence of uracil | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E1I
 | | Structure of RyR1 in the open state in the presence of oxopyricid | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E18
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9E17
 | | Structure of RyR1 in the primed state in the presence of caffeine (reprocessed/reanalyzed from EMPIAR-10997, 7TZC, EMD-26205) | | Descriptor: | (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.45 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E1B
 | | Structure of RyR1 in the open state in the presence of dyphylline | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.49 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E1F
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9E1A
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9E1D
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9E1C
 | | Structure of RyR1 in the primed state in the presence of IBMX | | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.63 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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8UQ3
 | | Structure of human RyR2-S2808D in the closed state in the presence of ARM210 | | Descriptor: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2023-10-23 | | Release date: | 2023-11-15 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
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8UQ4
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8UQ2
 | | Structure of human RyR2-S2808D in the subprimed state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2023-10-23 | | Release date: | 2023-11-15 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
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8UXC
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8UQ5
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8UXE
 | | Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 | | Descriptor: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2023-11-09 | | Release date: | 2023-11-22 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
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8UXG
 | | Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 | | Descriptor: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2023-11-09 | | Release date: | 2023-11-22 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.08 Å) | | Cite: | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
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8UXH
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8UXF
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8UXL
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8UXM
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8UXI
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7U9X
 | | Structure of PKA phosphorylated human RyR2-R2474S in the closed state | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2022-03-11 | | Release date: | 2022-08-03 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.58 Å) | | Cite: | Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment.
Sci Adv, 8, 2022
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