1JV5
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![BU of 1jv5 by Molmil](/molmil-images/mine/1jv5) | Anti-blood group A Fv | Descriptor: | Ig chain heavy chain precursor V region, Ig kappa chain precursor V region | Authors: | Thomas, R, Patenaude, S.I, MacKenzie, C.R, To, R, Hirama, T, Young, N.M, Evans, S.V. | Deposit date: | 2001-08-28 | Release date: | 2002-01-09 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of an anti-blood group A Fv and improvement of its binding affinity without loss of specificity. J.Biol.Chem., 277, 2002
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1BZ7
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![BU of 1bz7 by Molmil](/molmil-images/mine/1bz7) | FAB FRAGMENT FROM MURINE ASCITES | Descriptor: | PROTEIN (ANTIBODY R24 (HEAVY CHAIN)), PROTEIN (ANTIBODY R24 (LIGHT CHAIN)) | Authors: | Kaminski, M.J, Mackenzie, C.R, Mooibroek, M.J, Dahms, T.E.S, Hirama, T, Houghton, A.N, Chapman, P.B, Evans, S.V. | Deposit date: | 1998-11-06 | Release date: | 1999-11-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The role of homophilic binding in anti-tumor antibody R24 recognition of molecular surfaces. Demonstration of an intermolecular beta-sheet interaction between vh domains. J.Biol.Chem., 274, 1999
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1Q9O
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![BU of 1q9o by Molmil](/molmil-images/mine/1q9o) | S45-18 Fab Unliganded | Descriptor: | MAGNESIUM ION, S45-2 Fab (IgG1k) heavy chain, S45-2 Fab (IgG1k) light chain | Authors: | Nguyen, H.P, Seto, N.O, MacKenzie, C.R, Brade, L, Kosma, P, Brade, H, Evans, S.V. | Deposit date: | 2003-08-25 | Release date: | 2004-01-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Germline antibody recognition of distinct carbohydrate epitopes. Nat.Struct.Biol., 10, 2003
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1Q9L
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![BU of 1q9l by Molmil](/molmil-images/mine/1q9l) | S25-2 Fab Unliganded 2 | Descriptor: | MAGNESIUM ION, S25-2 Fab (IgG1k) heavy chain, S25-2 Fab (IgG1k) light chain, ... | Authors: | Nguyen, H.P, Seto, N.O, MacKenzie, C.R, Brade, L, Kosma, P, Brade, H, Evans, S.V. | Deposit date: | 2003-08-25 | Release date: | 2004-01-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Germline antibody recognition of distinct carbohydrate epitopes. Nat.Struct.Biol., 10, 2003
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1Q9W
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![BU of 1q9w by Molmil](/molmil-images/mine/1q9w) | S45-18 Fab pentasaccharide bisphosphate complex | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2-deoxy-4-O-phosphono-alpha-D-glucopyranose-(1-6)-2-amino-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, MAGNESIUM ION, ... | Authors: | Nguyen, H.P, Seto, N.O, MacKenzie, C.R, Brade, L, Kosma, P, Brade, H, Evans, S.V. | Deposit date: | 2003-08-26 | Release date: | 2004-01-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Germline antibody recognition of distinct carbohydrate epitopes. Nat.Struct.Biol., 10, 2003
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1Q9K
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![BU of 1q9k by Molmil](/molmil-images/mine/1q9k) | S25-2 Fab Unliganded 1 | Descriptor: | MAGNESIUM ION, S25-2 Fab (IgG1k) heavy chain, S25-2 Fab (IgG1k) light chain | Authors: | Nguyen, H.P, Seto, N.O, MacKenzie, C.R, Brade, L, Kosma, P, Brade, H, Evans, S.V. | Deposit date: | 2003-08-25 | Release date: | 2004-01-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Germline antibody recognition of distinct carbohydrate epitopes. Nat.Struct.Biol., 10, 2003
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4C83
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![BU of 4c83 by Molmil](/molmil-images/mine/4c83) | Crystal Structure of the IgG2a LPT3 in complex with an 8-sugar inner core analogue of Neisseria meningitidis | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-L-glycero-alpha-D-manno-heptopyranose-(1-3)-[beta-D-glucopyranose-(1-4)]L-glycero-alpha-D-manno-heptopyranose-(1-5)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, LPT3 HEAVY CHAIN, LPT3 LIGHT CHAIN, ... | Authors: | Parker, M.J, Gomery, K, Richard, G, Mackenzie, C.R, Cox, A.D, Richards, J.C, Evans, S.V. | Deposit date: | 2013-09-29 | Release date: | 2014-02-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structural Basis for Selective Cross-Reactivity in a Bactericidal Antibody Against Inner Core Lipooligosaccharide from Neisseria Meningitidis. Glycobiology, 24, 2014
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3T65
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![BU of 3t65 by Molmil](/molmil-images/mine/3t65) | S25-2- A(2-8)KDO disaccharide complex | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-8)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, MAGNESIUM ION, S25-2 FAB (IGG1K) heavy chain, ... | Authors: | Nguyen, H.P, Seto, N.O, Mackenzie, C.R, Brade, L, Kosma, P, Brade, H, Evans, S.V. | Deposit date: | 2011-07-28 | Release date: | 2011-08-17 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Germline antibody recognition of distinct carbohydrate epitopes. Nat.Struct.Biol., 10, 2003
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3SY0
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![BU of 3sy0 by Molmil](/molmil-images/mine/3sy0) | S25-2- A(2-8)-A(2-4)KDO trisaccharide complex | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-8)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, MAGNESIUM ION, S25-2 FAB (IGG1K) heavy chain, ... | Authors: | Nguyen, H.P, Seto, N.O, Mackenzie, C.R, Brade, L, Kosma, P, Brade, H, Evans, S.V. | Deposit date: | 2011-07-15 | Release date: | 2011-08-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.489 Å) | Cite: | Germline antibody recognition of distinct carbohydrate epitopes NAT.STRUCT.BIOL., 10, 2003
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3T4Y
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![BU of 3t4y by Molmil](/molmil-images/mine/3t4y) | S25-2- KDO monosaccharide complex | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, MAGNESIUM ION, S25-2 FAB (IGG1K) HEAVY CHAIN, ... | Authors: | Nguyen, H.P, Seto, N.O, Mackenzie, C.R, Brade, L, Kosma, P, Brade, H, Evans, S.V. | Deposit date: | 2011-07-26 | Release date: | 2011-08-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Germline antibody recognition of distinct carbohydrate epitopes. Nat.Struct.Biol., 10, 2003
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3T77
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![BU of 3t77 by Molmil](/molmil-images/mine/3t77) | S25-2- A(2-4)KDO disaccharide complex | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, MAGNESIUM ION, S25-2 FAB (IGG1K) heavy chain, ... | Authors: | Nguyen, H.P, Seto, N.O, Mackenzie, C.R, Brade, L, Kosma, P, Brade, H, Evans, S.V. | Deposit date: | 2011-07-29 | Release date: | 2011-08-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.739 Å) | Cite: | Germline antibody recognition of distinct carbohydrate epitopes. Nat.Struct.Biol., 10, 2003
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3HZV
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![BU of 3hzv by Molmil](/molmil-images/mine/3hzv) | Crystal structure of S73-2 antibody in complex with antigen Kdo(2.8)Kdo(2.4)Kdo | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-8)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, MAGNESIUM ION, S73-2 Fab (IgG1k) heavy chain, ... | Authors: | Brooks, C.L, Muller-Loennies, S, Borisova, S.N, Brade, L, Kosma, P, Hirama, T, MacKenzie, C.R, Brade, H, Evans, S.V. | Deposit date: | 2009-06-24 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition Biochemistry, 49, 2010
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3HZK
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![BU of 3hzk by Molmil](/molmil-images/mine/3hzk) | Crystal structure of S73-2 antibody in complex with antigen Kdo(2.4)Kdo | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, MAGNESIUM ION, S73-2 Fab (IgG1k) heavy chain, ... | Authors: | Brooks, C.L, Muller-Loennies, S, Borisova, S.N, Brade, L, Kosma, P, Hirama, T, MacKenzie, C.R, Brade, H, Evans, S.V. | Deposit date: | 2009-06-23 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition Biochemistry, 49, 2010
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3HZY
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![BU of 3hzy by Molmil](/molmil-images/mine/3hzy) | Crystal structure of S73-2 antibody in complex with antigen Kdo(2.4)Kdo(2.4)Kdo | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, MAGNESIUM ION, S73-2 Fab (IgG1k) heavy chain, ... | Authors: | Brooks, C.L, Muller-Loennies, S, Borisova, S.N, Brade, L, Kosma, P, Hirama, T, MacKenzie, C.R, Brade, H, Evans, S.V. | Deposit date: | 2009-06-24 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition Biochemistry, 49, 2010
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3I02
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![BU of 3i02 by Molmil](/molmil-images/mine/3i02) | Crystal structure of S54-10 antibody in complex with antigen Kdo(2.4)Kdo(2.4)Kdo | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, Immunoglobulin heavy chain, Immunoglobulin light chain | Authors: | Brooks, C.L, Muller-Loennies, S, Borisova, S.N, Brade, L, Kosma, P, Hirama, T, MacKenzie, C.R, Brade, H, Evans, S.V. | Deposit date: | 2009-06-24 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition Biochemistry, 49, 2010
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3HZM
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![BU of 3hzm by Molmil](/molmil-images/mine/3hzm) | Crystal structure of S73-2 antibody in complex with antigen Kdo | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid, MAGNESIUM ION, S73-2 Fab (IgG1k) heavy chain, ... | Authors: | Brooks, C.L, Muller-Loennies, S, Borisova, S.N, Brade, L, Kosma, P, Hirama, T, MacKenzie, C.R, Brade, H, Evans, S.V. | Deposit date: | 2009-06-23 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition Biochemistry, 49, 2010
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1MFA
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![BU of 1mfa by Molmil](/molmil-images/mine/1mfa) | |
1R24
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![BU of 1r24 by Molmil](/molmil-images/mine/1r24) | FAB FROM MURINE IGG3 KAPPA | Descriptor: | PROTEIN (IGG3-KAPPA ANTIBODY (HEAVY CHAIN)), PROTEIN (IGG3-KAPPA ANTIBODY (LIGHT CHAIN)) | Authors: | Evans, S.V. | Deposit date: | 1998-11-05 | Release date: | 1999-11-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The role of homophilic binding in anti-tumor antibody R24 recognition of molecular surfaces. Demonstration of an intermolecular beta-sheet interaction between vh domains. J.Biol.Chem., 274, 1999
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1MVU
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![BU of 1mvu by Molmil](/molmil-images/mine/1mvu) | |
3BPC
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![BU of 3bpc by Molmil](/molmil-images/mine/3bpc) | co-crystal structure of S25-2 Fab in complex with 5-deoxy-4-epi-2,3-dehydro Kdo (4.8) Kdo | Descriptor: | 3,4,5-trideoxy-alpha-D-erythro-oct-3-en-2-ulopyranosonic acid-(2-8)-prop-2-en-1-yl 3-deoxy-alpha-D-manno-oct-2-ulopyranosidonic acid, Fab, antibody fragment (IgG1k), ... | Authors: | Brooks, C.L, Evans, S.V. | Deposit date: | 2007-12-18 | Release date: | 2009-01-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes. J.Mol.Biol., 377, 2008
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6C5H
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![BU of 6c5h by Molmil](/molmil-images/mine/6c5h) | S25-5 Fab in complex with Chlamydiaceae-specific LPS antigen | Descriptor: | 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-8)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2-deoxy-4-O-phosphono-beta-D-glucopyranose-(1-6)-2-amino-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Evans, S.V, Haji-Ghassemi, O. | Deposit date: | 2018-01-16 | Release date: | 2019-01-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude. Biochemistry, 58, 2019
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6C5K
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![BU of 6c5k by Molmil](/molmil-images/mine/6c5k) | S25-23 Fab in complex with Chlamydiaceae LPS (Crystal form 2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-8)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2-deoxy-4-O-phosphono-beta-D-glucopyranose-(1-6)-2-amino-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, IgG1 Fab Heavy Chain, ... | Authors: | Haji-Ghassemi, O, Evans, S.V. | Deposit date: | 2018-01-16 | Release date: | 2019-01-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude. Biochemistry, 58, 2019
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6C5I
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![BU of 6c5i by Molmil](/molmil-images/mine/6c5i) | Unliganded S25-5 Fab | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Evans, S.V, Haji-Ghassemi, O. | Deposit date: | 2018-01-16 | Release date: | 2019-01-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude. Biochemistry, 58, 2019
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6C5J
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![BU of 6c5j by Molmil](/molmil-images/mine/6c5j) | S25-23 Fab in complex with Chlamydiaceae LPS (Crystal form 1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-8)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2-deoxy-4-O-phosphono-beta-D-glucopyranose-(1-6)-2-amino-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, IgG1 Fab Heavy Chain, ... | Authors: | Haji-Ghassemi, O, Evans, S.V. | Deposit date: | 2018-01-16 | Release date: | 2019-01-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude. Biochemistry, 58, 2019
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2R2H
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![BU of 2r2h by Molmil](/molmil-images/mine/2r2h) | Structure of S25-2 in Complex with Ko | Descriptor: | Fab, antibody fragment (IgG1k), heavy chain, ... | Authors: | Brooks, C.L, Evans, S.V. | Deposit date: | 2007-08-25 | Release date: | 2008-12-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Exploration of specificity in germline monoclonal antibody recognition of a range of natural and synthetic epitopes. J.Mol.Biol., 377, 2008
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