6C5K

S25-23 Fab in complex with Chlamydiaceae LPS (Crystal form 2)

Summary for 6C5K

• Entry DOI: 10.2210/pdb6c5k/pdb
• Related: 6C5H 6C5I 6C5J
• Descriptor: IgG1 Fab Heavy Chain, IgG1 Fab Light Chain (Kappa), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: carbohydrate, lipopolysaccharide, antibody, antigen, complex, chlamydia, sugar binding protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 4
• Total formula weight: 98801.40

Authors

Haji-Ghassemi, O.,Evans, S.V. (deposition date: 2018-01-16, release date: 2019-01-09, Last modification date: 2023-10-04)

• Primary citation: Haji-Ghassemi, O.,Muller-Loennies, S.,Brooks, C.L.,MacKenzie, C.R.,Caveney, N.,Van Petegem, F.,Brade, L.,Kosma, P.,Brade, H.,Evans, S.V.; Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.; Biochemistry, 58:714-726, 2019; PubMed: 30571096; DOI: 10.1021/acs.biochem.8b00318

Experimental method

X-RAY DIFFRACTION (1.75 Å)