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6C5J

S25-23 Fab in complex with Chlamydiaceae LPS (Crystal form 1)

Summary for 6C5J
Entry DOI10.2210/pdb6c5j/pdb
Related6C5H 6C5I
DescriptorIgG1 Fab Heavy Chain, IgG1 Fab Light Chain (Kappa), 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-8)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2-deoxy-4-O-phosphono-beta-D-glucopyranose-(1-6)-2-amino-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, ... (5 entities in total)
Functional Keywordscarbohydrate, lipopolysaccharide, antibody, antigen, complex, chlamydia, sugar binding protein, immune system
Biological sourceMus musculus (Mouse)
More
Total number of polymer chains2
Total formula weight49038.38
Authors
Haji-Ghassemi, O.,Evans, S.V. (deposition date: 2018-01-16, release date: 2019-01-09, Last modification date: 2023-10-04)
Primary citationHaji-Ghassemi, O.,Muller-Loennies, S.,Brooks, C.L.,MacKenzie, C.R.,Caveney, N.,Van Petegem, F.,Brade, L.,Kosma, P.,Brade, H.,Evans, S.V.
Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.
Biochemistry, 58:714-726, 2019
Cited by
PubMed: 30571096
DOI: 10.1021/acs.biochem.8b00318
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.29 Å)
Structure validation

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