1QM7
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![BU of 1qm7 by Molmil](/molmil-images/mine/1qm7) | X-ray structure of a three-fingered chimeric protein, stability of a structural scaffold | Descriptor: | R-CHII | Authors: | Le Du, M.H, Ricciardi, A, Khayati, M, Menez, R, Boulain, J.C, Menez, A, Ducancel, F. | Deposit date: | 1999-09-21 | Release date: | 2000-03-15 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Stability of a Structural Scaffold Upon Activity Transfer : X-Ray Structure of a Three Fingers Chimeric Protein. J.Mol.Biol., 296, 2000
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1FAS
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![BU of 1fas by Molmil](/molmil-images/mine/1fas) | 1.9 ANGSTROM RESOLUTION STRUCTURE OF FASCICULIN 1, AN ANTI-ACETYLCHOLINESTERASE TOXIN FROM GREEN MAMBA SNAKE VENOM | Descriptor: | FASCICULIN 1 | Authors: | Le Du, M.H, Marchot, P, Bougis, P.E, Fontecilla-Camps, J.C. | Deposit date: | 1992-08-07 | Release date: | 1993-10-31 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | 1.9-A resolution structure of fasciculin 1, an anti-acetylcholinesterase toxin from green mamba snake venom. J.Biol.Chem., 267, 1992
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1EW2
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![BU of 1ew2 by Molmil](/molmil-images/mine/1ew2) | CRYSTAL STRUCTURE OF A HUMAN PHOSPHATASE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, PHOSPHATASE, ... | Authors: | Le Du, M.H, Stigbrand, T, Taussig, M.J, Menez, A, Stura, E.A. | Deposit date: | 2000-04-21 | Release date: | 2001-04-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity. J.Biol.Chem., 276, 2001
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1KH5
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![BU of 1kh5 by Molmil](/molmil-images/mine/1kh5) | E. COLI ALKALINE PHOSPHATASE MUTANT (D330N) MIMIC OF THE TRANSITION STATES WITH ALUMINIUM FLUORIDE | Descriptor: | ALKALINE PHOSPHATASE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E. | Deposit date: | 2001-11-29 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. J.Mol.Biol., 316, 2002
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1KHJ
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![BU of 1khj by Molmil](/molmil-images/mine/1khj) | E. COLI ALKALINE PHOSPHATASE MUTANT (D153HD330N) MIMIC OF THE TRANSITION STATES WITH ALUMINIUM FLUORIDE | Descriptor: | ALUMINUM FLUORIDE, Alkaline phosphatase, ZINC ION | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E, Menez, A, Boulain, J.C. | Deposit date: | 2001-11-30 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. J.Mol.Biol., 316, 2002
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1KHN
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![BU of 1khn by Molmil](/molmil-images/mine/1khn) | E. COLI ALKALINE PHOSPHATASE MUTANT (D153HD330N) ZINC FORM | Descriptor: | Alkaline phosphatase, ZINC ION | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E, Menez, A, Boulain, J.C. | Deposit date: | 2001-11-30 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. J.Mol.Biol., 316, 2002
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1KH4
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![BU of 1kh4 by Molmil](/molmil-images/mine/1kh4) | E. COLI ALKALINE PHOSPHATASE MUTANT (D330N) IN COMPLEX WITH PHOSPHATE | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E. | Deposit date: | 2001-11-29 | Release date: | 2002-03-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. J.Mol.Biol., 316, 2002
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1KH9
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![BU of 1kh9 by Molmil](/molmil-images/mine/1kh9) | E. COLI ALKALINE PHOSPHATASE MUTANT (D153GD330N) COMPLEX WITH PHOSPHATE | Descriptor: | Alkaline phosphatase, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E. | Deposit date: | 2001-11-29 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. J.Mol.Biol., 316, 2002
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1KHK
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![BU of 1khk by Molmil](/molmil-images/mine/1khk) | E. COLI ALKALINE PHOSPHATASE MUTANT (D153HD330N) | Descriptor: | Alkaline Phosphatase, MAGNESIUM ION, ZINC ION | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E, Menez, A, Boulain, J.C. | Deposit date: | 2001-11-30 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. J.Mol.Biol., 316, 2002
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1KH7
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![BU of 1kh7 by Molmil](/molmil-images/mine/1kh7) | E. COLI ALKALINE PHOSPHATASE MUTANT (D153GD330N) | Descriptor: | MAGNESIUM ION, SULFATE ION, ZINC ION, ... | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E. | Deposit date: | 2001-11-29 | Release date: | 2002-03-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. J.Mol.Biol., 316, 2002
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1KHL
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![BU of 1khl by Molmil](/molmil-images/mine/1khl) | E. COLI ALKALINE PHOSPHATASE MUTANT (D153HD330N) COMPLEX WITH PHOSPHATE | Descriptor: | Alkaline Phosphatase, PHOSPHATE ION, ZINC ION | Authors: | Le Du, M.H, Lamoure, C, Muller, B.H, Bulgakov, O.V, Lajeunesse, E, Menez, A, Boulain, J.C. | Deposit date: | 2001-11-30 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. J.Mol.Biol., 316, 2002
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1FSC
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7BDX
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![BU of 7bdx by Molmil](/molmil-images/mine/7bdx) | Armadillo domain of HSF2BP in complex with BRCA2 peptide | Descriptor: | Breast cancer type 2 susceptibility protein, Heat shock factor 2-binding protein, MAGNESIUM ION | Authors: | Le Du, M.H, Zinn-Justin, S, Ghouil, R, Miron, S, Legrand, P. | Deposit date: | 2020-12-22 | Release date: | 2021-07-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination. Nat Commun, 12, 2021
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7NDY
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![BU of 7ndy by Molmil](/molmil-images/mine/7ndy) | Di-phosphorylated Barrier-to-Autointegration Factor (BAF) in complex with LEM domain of Emerin | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Barrier-to-autointegration factor, N-terminally processed, ... | Authors: | Marcelot, A, Le Du, M.H, Hoffmann, G, Zinn-Justin, S. | Deposit date: | 2021-02-02 | Release date: | 2021-04-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners. Nucleic Acids Res., 49, 2021
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6F0G
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![BU of 6f0g by Molmil](/molmil-images/mine/6f0g) | Crystal structure ASF1-ip3 | Descriptor: | Histone chaperone ASF1A, SULFATE ION, ip3 | Authors: | Gaubert, A, Guichard, B, Richet, N, Le Du, M.H, Andreani, J, Guerois, R, Ochsenbein, F. | Deposit date: | 2017-11-20 | Release date: | 2019-06-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1. Cell Chem Biol, 26, 2019
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6F0F
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![BU of 6f0f by Molmil](/molmil-images/mine/6f0f) | Crystal structure ASF1-ip2_s | Descriptor: | Histone chaperone ASF1A, ip2_s | Authors: | Gaubert, A, Guichard, B, Murciano, B, Le Du, M.H, Ochsenbein, F, Guerois, R, Andreani, J. | Deposit date: | 2017-11-20 | Release date: | 2019-06-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1. Cell Chem Biol, 26, 2019
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6F0H
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![BU of 6f0h by Molmil](/molmil-images/mine/6f0h) | Crystal structure ASF1-ip4 | Descriptor: | CITRIC ACID, GLYCEROL, Histone chaperone ASF1A, ... | Authors: | Bakail, M, Richet, N, Le Du, M.H, Andreani, J, Guerois, R, Ochsenbein, F. | Deposit date: | 2017-11-20 | Release date: | 2019-06-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1. Cell Chem Biol, 26, 2019
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1RCN
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![BU of 1rcn by Molmil](/molmil-images/mine/1rcn) | CRYSTAL STRUCTURE OF THE RIBONUCLEASE A D(APTPAPAPG) COMPLEX : DIRECT EVIDENCE FOR EXTENDED SUBSTRATE RECOGNITION | Descriptor: | DNA (5'-D(*AP*TP*AP*A)-3'), PROTEIN (RIBONUCLEASE A (E.C.3.1.27.5)) | Authors: | Fontecilla-Camps, J.C, De Llorens, R, Le Du, M.H, Cuchillo, C.M. | Deposit date: | 1994-05-27 | Release date: | 1994-09-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Crystal structure of ribonuclease A.d(ApTpApApG) complex. Direct evidence for extended substrate recognition. J.Biol.Chem., 269, 1994
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2H7Z
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![BU of 2h7z by Molmil](/molmil-images/mine/2h7z) | Crystal structure of irditoxin | Descriptor: | Irditoxin subunit A, Irditoxin subunit B | Authors: | Pawlak, J, Kini, R.M, Stura, E.A, Le Du, M.H. | Deposit date: | 2006-06-06 | Release date: | 2006-08-29 | Last modified: | 2011-10-05 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity. Faseb J., 23, 2009
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2HEO
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![BU of 2heo by Molmil](/molmil-images/mine/2heo) | General Structure-Based Approach to the Design of Protein Ligands: Application to the Design of Kv1.2 Potassium Channel Blockers. | Descriptor: | 5'-D(*TP*CP*GP*CP*GP*CP*G)-3', Z-DNA binding protein 1 | Authors: | Magis, C, Gasparini, S, Charbonnier, J.B, Stura, E, Le Du, M.H, Menez, A, Cuniasse, P. | Deposit date: | 2006-06-21 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure-based secondary structure-independent approach to design protein ligands: Application to the design of Kv1.2 potassium channel blockers. J.Am.Chem.Soc., 128, 2006
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2GLQ
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![BU of 2glq by Molmil](/molmil-images/mine/2glq) | X-ray structure of human alkaline phosphatase in complex with strontium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, placental type, ... | Authors: | Llinas, P, Masella, M, Stigbrand, T, Menez, A, Stura, E.A, Le Du, M.H. | Deposit date: | 2006-04-05 | Release date: | 2006-04-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural studies of human alkaline phosphatase in complex with strontium: Implication for its secondary effect in bones. Protein Sci., 15, 2006
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3G5H
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![BU of 3g5h by Molmil](/molmil-images/mine/3g5h) | Crystallographic analysis of cytochrome P450 cyp121 | Descriptor: | (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Belin, P, Le Du, M.H, Gondry, M. | Deposit date: | 2009-02-05 | Release date: | 2009-04-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.USA, 106, 2009
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3G5F
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![BU of 3g5f by Molmil](/molmil-images/mine/3g5f) | Crystallographic analysis of cytochrome P450 cyp121 | Descriptor: | Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | Authors: | Belin, P, Le Du, M.H, Gondry, M. | Deposit date: | 2009-02-05 | Release date: | 2009-04-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.USA, 106, 2009
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7Q5G
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![BU of 7q5g by Molmil](/molmil-images/mine/7q5g) | LAN-DAP5 DERIVATIVE OF LANREOTIDE: L-DIAMINO PROPIONIC ACID IN POSITION 5 IN PLACE OF L-LYSINE | Descriptor: | ETHANOL, LAN-DAP5 DERIVATIVE OF LANREOTIDE | Authors: | Bressanelli, S, Le Du, M.H, Gobeaux, F, Legrand, P, Paternostre, M. | Deposit date: | 2021-11-03 | Release date: | 2022-02-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (0.83 Å) | Cite: | Atomic structure of Lanreotide nanotubes revealed by cryo-EM. Proc.Natl.Acad.Sci.USA, 119, 2022
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7ABM
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![BU of 7abm by Molmil](/molmil-images/mine/7abm) | X-ray structure of phosphorylated Barrier-to-autointegration factor (BAF) | Descriptor: | Barrier-to-autointegration factor, CESIUM ION | Authors: | Zinn-Justin, S, Marcelot, A, Le Du, M.H, Ropars, V. | Deposit date: | 2020-09-08 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.004 Å) | Cite: | Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners. Nucleic Acids Res., 49, 2021
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