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3KXC
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BU of 3kxc by Molmil
Mutant transport protein
Descriptor: PALMITIC ACID, Trafficking protein particle complex subunit 3, Trafficking protein particle complex subunit 6B
Authors:Kummel, D, Heinemann, U.
Deposit date:2009-12-02
Release date:2010-04-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of the self-palmitoylation activity of the transport protein particle component Bet3
Cell.Mol.Life Sci., 67, 2010
2CFH
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BU of 2cfh by Molmil
Structure of the Bet3-TPC6B core of TRAPP
Descriptor: PALMITIC ACID, TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3, TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B
Authors:Kummel, D, Muller, J.J, Roske, Y, Henke, N, Heinemann, U.
Deposit date:2006-02-21
Release date:2006-07-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Bet3-Tpc6B Core of Trapp: Two Tpc6 Paralogs Form Trimeric Complexes with Bet3 and Mum2.
J.Mol.Biol., 361, 2006
2BJN
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BU of 2bjn by Molmil
X-ray Structure of human TPC6
Descriptor: GLYCEROL, SULFATE ION, TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B
Authors:Kummel, D, Mueller, J.J, Roske, Y, Misselwitz, R, Bussow, K, Heinemann, U.
Deposit date:2005-02-04
Release date:2005-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structure of the Trapp Subunit Tpc6 Suggests a Model for a Trapp Subcomplex.
Embo Rep., 6, 2005
3TW8
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BU of 3tw8 by Molmil
GEF domain of DENND 1B in complex with Rab GTPase Rab35
Descriptor: DENN domain-containing protein 1B, Ras-related protein Rab-35
Authors:Wu, X.D, Kummel, D, Reinisch, K.M.
Deposit date:2011-09-21
Release date:2011-11-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.
Proc.Natl.Acad.Sci.USA, 108, 2011
5HIU
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BU of 5hiu by Molmil
Structure of the TSC2 N-terminus
Descriptor: GTPase activator-like protein
Authors:Zech, R, Kiontke, S, Kummel, D.
Deposit date:2016-01-12
Release date:2016-08-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.
J.Biol.Chem., 291, 2016
2W3C
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BU of 2w3c by Molmil
Globular head region of the human general vesicular transport factor p115
Descriptor: DI(HYDROXYETHYL)ETHER, GENERAL VESICULAR TRANSPORT FACTOR P115
Authors:Striegl, H, Roske, Y, Kummel, D, Heinemann, U.
Deposit date:2008-11-11
Release date:2009-03-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Unusual Armadillo Fold in the Human General Vesicular Transport Factor P115
Plos One, 4, 2009
8CPN
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BU of 8cpn by Molmil
Crystal structure of the PolB16_OarG intein variant S1A, N183A
Descriptor: IODIDE ION, PolB16 intein
Authors:Kattelmann, S, Pasch, T, Mootz, H.D, Kummel, D.
Deposit date:2023-03-03
Release date:2023-05-17
Last modified:2023-05-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins.
Chem Sci, 14, 2023
6SSH
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BU of 6ssh by Molmil
Structure of the TSC2 GAP domain
Descriptor: 1,2-ETHANEDIOL, GTPase activator-like protein
Authors:Hansmann, P, Kiontke, S, Kummel, D.
Deposit date:2019-09-06
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations.
Structure, 28, 2020
6ZFM
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BU of 6zfm by Molmil
Structure of alpha-Cobratoxin with a peptide inhibitor
Descriptor: 3-[2-[2-[2-[2-[2-(2-azanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propan-1-ol, Alpha-cobratoxin, PENTAETHYLENE GLYCOL, ...
Authors:Kiontke, S, Kummel, D.
Deposit date:2020-06-17
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Peptide Inhibitors of the alpha-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.
J.Med.Chem., 63, 2020
7FSE
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BU of 7fse by Molmil
Crystal Structure of T. maritima reverse gyrase with a minimal latch
Descriptor: CHLORIDE ION, DODECAETHYLENE GLYCOL, Reverse gyrase, ...
Authors:Rasche, R, Kummel, D, Rudolph, M.G, Klostermeier, D.
Deposit date:2023-01-04
Release date:2023-05-10
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
Acta Crystallogr D Struct Biol, 79, 2023
7FSF
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BU of 7fsf by Molmil
CRYSTAL STRUCTURE OF T. MARITIMA REVERSE GYRASE ACTIVE SITE VARIANT Y851F
Descriptor: Reverse gyrase, ZINC ION
Authors:Rasche, R, Kummel, D, Rudolph, M.G, Klostermeier, D.
Deposit date:2023-01-04
Release date:2023-05-10
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
Acta Crystallogr D Struct Biol, 79, 2023
1TBX
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BU of 1tbx by Molmil
Crystal structure of SSV1 F-93
Descriptor: Hypothetical 11.0 kDa protein
Authors:Kraft, P, Oeckinghaus, A, Kummel, D, Gauss, G.H, Wiedenheft, B, Young, M, Lawrence, C.M.
Deposit date:2004-05-20
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of F-93 from Sulfolobus spindle-shaped virus 1, a winged-helix DNA binding protein.
J.Virol., 78, 2004
8OFB
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BU of 8ofb by Molmil
Crystal Structure of T. maritima reverse gyrase with a minimal latch, hexagonal form
Descriptor: CHLORIDE ION, HEXAETHYLENE GLYCOL, Reverse gyrase, ...
Authors:Klostermeier, D, Rasche, R, Mhaindarkar, V, Kummel, D, Rudolph, M.G.
Deposit date:2023-03-15
Release date:2023-04-26
Last modified:2023-06-07
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain.
Acta Crystallogr D Struct Biol, 79, 2023
3RL0
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BU of 3rl0 by Molmil
Truncated SNARE complex with complexin (P1)
Descriptor: Complexin-1, Synaptosomal-associated protein 25, Syntaxin-1A, ...
Authors:Kuemmel, D, Reinisch, K.M.
Deposit date:2011-04-19
Release date:2011-07-27
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Complexin cross-links prefusion SNAREs into a zigzag array.
Nat.Struct.Mol.Biol., 18, 2011
3RK2
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BU of 3rk2 by Molmil
Truncated SNARE complex
Descriptor: CALCIUM ION, Synaptosomal-associated protein 25, Syntaxin-1A, ...
Authors:Kuemmel, D, Reinisch, K.M.
Deposit date:2011-04-17
Release date:2011-07-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Complexin cross-links prefusion SNAREs into a zigzag array.
Nat.Struct.Mol.Biol., 18, 2011
3RK3
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BU of 3rk3 by Molmil
Truncated SNARE complex with complexin
Descriptor: Complexin-1, SNAP25, Syntaxin 1a, ...
Authors:Kuemmel, D, Reinisch, K.M.
Deposit date:2011-04-17
Release date:2011-07-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Complexin cross-links prefusion SNAREs into a zigzag array.
Nat.Struct.Mol.Biol., 18, 2011
7ZTY
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BU of 7zty by Molmil
Structure of Vps39 N-terminal domain from Chaetomium thermophilum
Descriptor: CNH domain-containing protein
Authors:Kiontke, S, Ungermann, C, Kuemmel, D.
Deposit date:2022-05-11
Release date:2022-09-21
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Elife, 11, 2022
5LDD
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BU of 5ldd by Molmil
Crystal structure of the heterodimeric GEF Mon1-Ccz1 in complex with Ypt7
Descriptor: Ccz1, Mon1, Rab small monomeric GTPase-like protein, ...
Authors:Kiontke, S, Kuemmel, D.
Deposit date:2016-06-24
Release date:2017-01-18
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.496 Å)
Cite:Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.
Nat Commun, 8, 2017
4UUY
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BU of 4uuy by Molmil
Structural Identification of the Vps18 beta-propeller reveals a critical role in the HOPS complex stability and function.
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ...
Authors:Behrmann, H, Gohlke, U, Heinemann, U.
Deposit date:2014-08-01
Release date:2014-10-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural Identification of the Vps18 Beta-Propeller Reveals a Critical Role in the Hops Complex Stability and Function.
J.Biol.Chem., 289, 2014
8C7G
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BU of 8c7g by Molmil
Drosophila melanogaster Rab7 GEF complex Mon1-Ccz1-Bulli
Descriptor: Caffeine, calcium, zinc sensitivity 1, ...
Authors:Schaefer, J, Herrmann, E, Kuemmel, D, Moeller, A.
Deposit date:2023-01-15
Release date:2023-05-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the metazoan Rab7 GEF complex Mon1-Ccz1-Bulli.
Proc.Natl.Acad.Sci.USA, 120, 2023
8CPO
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BU of 8cpo by Molmil
Crystal structure of the PolB16_OarG intein variant S1A, N183A, C111A, C165A
Descriptor: PolB16 Intein Cys-less
Authors:Kattelmann, S, Pasch, T, Mootz, H.D, Kuemmel, D.
Deposit date:2023-03-03
Release date:2023-05-17
Last modified:2023-05-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins.
Chem Sci, 14, 2023
8CCI
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BU of 8cci by Molmil
Crystal structure of Mycobacterium smegmatis thioredoxin reductase
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ...
Authors:Fuesser, F.T, Koch, O, Kuemmel, D.
Deposit date:2023-01-27
Release date:2023-07-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Novel starting points for fragment-based drug design against mycobacterial thioredoxin reductase identified using crystallographic fragment screening.
Acta Crystallogr D Struct Biol, 79, 2023
7ZU0
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BU of 7zu0 by Molmil
HOPS tethering complex from yeast
Descriptor: E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar morphogenesis protein 6, ...
Authors:Shvarev, D, Schoppe, J, Koenig, C, Perz, A, Fuellbrunn, N, Kiontke, S, Langemeyer, L, Januliene, D, Schnelle, K, Kuemmel, D, Froehlich, F, Moeller, A, Ungermann, C.
Deposit date:2022-05-11
Release date:2022-09-28
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Elife, 11, 2022
7QLA
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BU of 7qla by Molmil
Structure of the Rab GEF complex Mon1-Ccz1
Descriptor: Ccz1, Vacuolar fusion protein MON1
Authors:Klink, B.U, Herrmann, E, Antoni, C, Langemeyer, L, Kiontke, S, Gatsogiannis, C, Ungermann, C, Raunser, S, Kuemmel, D.
Deposit date:2021-12-20
Release date:2022-02-09
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
6ZGQ
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BU of 6zgq by Molmil
AceL NrdHF class 3 split intein GSH linked splice inactive variant - C124A, N146A
Descriptor: AceL NrdHF-1-1 Intein, IODIDE ION
Authors:Hoffmann, S, Mootz, H.D, Kuemmel, D, Singh, R.
Deposit date:2020-06-19
Release date:2020-09-16
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Biochemical and Structural Characterization of an Unusual and Naturally Split Class 3 Intein.
Chembiochem, 22, 2021

 

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数据于2024-06-12公开中

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