5XJA
 
 | | The Crystal Structure of the Minimal Core Domain of the Microtubule Depolymerizer KIF2C Complexed with ADP-Mg-AlFx | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Kinesin-like protein KIF2C, ... | | Authors: | Ogawa, T, Jiang, X, Hirokawa, N. | | Deposit date: | 2017-04-30 | | Release date: | 2017-09-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.43 Å) | | Cite: | Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation
Cell Rep, 20, 2017
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1IA0
 | | KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-LIKE PROTEIN KIF1A, ... | | Authors: | Kikkawa, M, Sablin, E.P, Okada, Y, Yajima, H, Fletterick, R.J, Hirokawa, N. | | Deposit date: | 2001-03-22 | | Release date: | 2002-03-22 | | Last modified: | 2021-10-27 | | Method: | ELECTRON MICROSCOPY (15 Å) | | Cite: | Switch-based Mechanism of Kinesin Motors
Nature, 411, 2001
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3J7I
 | | Structure of alpha- and beta- tubulin in GMPCPP-microtubules | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Tubulin alpha-1A chain, ... | | Authors: | Yajima, H, Ogura, T, Nitta, R, Okada, Y, Sato, C, Hirokawa, N. | | Deposit date: | 2014-07-01 | | Release date: | 2014-12-10 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.9 Å) | | Cite: | Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy
J.Cell Biol., 198, 2012
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3WRD
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5GSY
 | | Kinesin-8 motor, KIF19A, in the nucleotide-free state complexed with GDP-taxol microtubule | | Descriptor: | Kinesin-like protein KIF19 | | Authors: | Morikawa, M, Nitta, R, Yajima, H, Shigematsu, H, Kikkawa, M, Hirokawa, N. | | Deposit date: | 2016-08-17 | | Release date: | 2016-09-28 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
Elife, 5, 2016
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5GSZ
 | | Crystal Structure of the KIF19A Motor Domain Complexed with Mg-ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF19, MAGNESIUM ION | | Authors: | Wang, D, Nitta, R, Hirokawa, N. | | Deposit date: | 2016-08-18 | | Release date: | 2016-09-28 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A
Elife, 5, 2016
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2HXF
 | | KIF1A head-microtubule complex structure in amppnp-form | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | | Authors: | Kikkawa, M, Hirokawa, N. | | Deposit date: | 2006-08-03 | | Release date: | 2006-10-10 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (10 Å) | | Cite: | High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations
Embo J., 25, 2006
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2HXH
 | | KIF1A head-microtubule complex structure in adp-form | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Kikkawa, M, Hirokawa, N. | | Deposit date: | 2006-08-03 | | Release date: | 2006-10-10 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (11 Å) | | Cite: | High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations
Embo J., 25, 2006
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1I6I
 | | CRYSTAL STRUCTURE OF THE KIF1A MOTOR DOMAIN COMPLEXED WITH MG-AMPPCP | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, KINESIN-LIKE PROTEIN KIF1A, MAGNESIUM ION, ... | | Authors: | Kikkawa, M, Sablin, E.P, Okada, Y, Yajima, H, Fletterick, R.J, Hirokawa, N. | | Deposit date: | 2001-03-02 | | Release date: | 2001-05-30 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Switch-based mechanism of kinesin motors
Nature, 411, 2001
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1I5S
 | | CRYSTAL STRUCTURE OF THE KIF1A MOTOR DOMAIN COMPLEXED WITH MG-ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF1A, MAGNESIUM ION | | Authors: | Kikkawa, M, Sablin, E.P, Okada, Y, Yajima, H, Fletterick, R.J, Hirokawa, N. | | Deposit date: | 2001-02-28 | | Release date: | 2001-05-30 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Switch-based mechanism of kinesin motors
Nature, 411, 2001
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3J6H
 | | Nucleotide-free Kinesin motor domain complexed with GMPCPP-microtubule | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin heavy chain isoform 5C, MAGNESIUM ION, ... | | Authors: | Morikawa, M, Yajima, H, Nitta, R, Inoue, S, Ogura, T, Sato, C, Hirokawa, N. | | Deposit date: | 2014-02-21 | | Release date: | 2015-04-01 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (8.1 Å) | | Cite: | X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding
Embo J., 2015
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3X2T
 | | Crystal Structure of the KIF5C Motor Domain With ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin heavy chain isoform 5C | | Authors: | Inoue, S, Nitta, R, Hirokawa, N. | | Deposit date: | 2015-01-02 | | Release date: | 2015-04-01 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding
Embo J., 34, 2015
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3ZFD
 | | Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP | | Descriptor: | CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. | | Deposit date: | 2012-12-11 | | Release date: | 2013-03-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Structural Basis for the ATP-Induced Isomerization of Kinesin.
J.Mol.Biol., 425, 2013
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3ZFC
 | | Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP | | Descriptor: | CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. | | Deposit date: | 2012-12-11 | | Release date: | 2013-03-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis for the ATP-Induced Isomerization of Kinesin.
J.Mol.Biol., 425, 2013
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2ZFI
 | | Crystal Structure of the Kif1A Motor Domain Before Mg Release | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF1A, Kinesin heavy chain isoform 5C, ... | | Authors: | Nitta, R, Okada, Y, Hirokawa, N. | | Deposit date: | 2008-01-07 | | Release date: | 2008-09-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin.
Nat.Struct.Mol.Biol., 15, 2008
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2ZFJ
 | | Crystal Structure of the Kif1A Motor Domain during Mg release: Mg-releasing Transition-1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF1A, Kinesin heavy chain isoform 5C, ... | | Authors: | Nitta, R, Okada, Y, Hirokawa, N. | | Deposit date: | 2008-01-08 | | Release date: | 2008-09-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin.
Nat.Struct.Mol.Biol., 15, 2008
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2ZFM
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2ZFL
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2ZFK
 | | Crystal Structure of the Kif1A Motor Domain during Mg release: Mg-releasing Transition-2 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF1A, ... | | Authors: | Nitta, R, Okada, Y, Hirokawa, N. | | Deposit date: | 2008-01-08 | | Release date: | 2008-09-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.61 Å) | | Cite: | Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin.
Nat.Struct.Mol.Biol., 15, 2008
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6JVB
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6JV9
 | | Crystal Structure of Human CRMP2 1-532, unmodified | | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Dihydropyrimidinase-related protein 2, ... | | Authors: | Jiang, X, Ogawa, T, Hirokawa, N. | | Deposit date: | 2019-04-16 | | Release date: | 2019-10-09 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis.
Life Sci Alliance, 2, 2019
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5XJB
 | | The Crystal Structure of the Minimal Core Domain of the Microtubule Depolymerizer KIF2C Complexed with ADP-Mg-BeFx | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Kinesin-like protein KIF2C, ... | | Authors: | Ogawa, T, Jiang, X, Hirokawa, N. | | Deposit date: | 2017-04-30 | | Release date: | 2017-09-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation
Cell Rep, 20, 2017
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1VFZ
 | | Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-VO4 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (Fusion protein consisting of Kinesin-like protein KIF1A, ... | | Authors: | Nitta, R, Kikkawa, M, Okada, Y, Hirokawa, N. | | Deposit date: | 2004-04-19 | | Release date: | 2004-08-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | KIF1A Alternately Uses Two Loops to Bind Microtubules
Science, 305, 2004
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1VFW
 | | Crystal Structure of the Kif1A Motor Domain Complexed With Mg-AMPPNP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PROTEIN (Fusion protein consisting of Kinesin-like protein KIF1A, ... | | Authors: | Nitta, R, Kikkawa, M, Okada, Y, Hirokawa, N. | | Deposit date: | 2004-04-19 | | Release date: | 2004-08-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | KIF1A Alternately Uses Two Loops to Bind Microtubules
Science, 305, 2004
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1V8K
 | | The Crystal Structure of the Minimal Functional Domain of the Microtubule Destabilizer KIF2C Complexed with Mg-AMPPNP | | Descriptor: | Kinesin-like protein KIF2C, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Ogawa, T, Nitta, R, Okada, Y, Hirokawa, N. | | Deposit date: | 2004-01-09 | | Release date: | 2004-03-02 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | A common mechanism for microtubule destabilizers-M type kinesins stabilize curling of the protofilament using the class-specific neck and loops.
Cell(Cambridge,Mass.), 116, 2004
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