1JJH
 
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1BY9
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2BOP
 | | CRYSTAL STRUCTURE AT 1.7 ANGSTROMS OF THE BOVINE PAPILLOMAVIRUS-1 E2 DNA-BINDING DOMAIN BOUND TO ITS DNA TARGET | | Descriptor: | DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*TP*CP*G )-3'), PROTEIN (E2), YTTERBIUM (III) ION | | Authors: | Hegde, R.S, Grossman, S.R, Laimins, L.A, Sigler, P.B. | | Deposit date: | 1994-01-13 | | Release date: | 1994-01-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target.
Nature, 359, 1992
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6Y4L
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6Z3W
 | | Human ER membrane protein complex | | Descriptor: | ER membrane protein complex subunit 1,ER membrane protein complex subunit 1,ER membrane protein complex subunit 1,ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ... | | Authors: | Hegde, R.S, O'Donnell, J.P. | | Deposit date: | 2020-05-22 | | Release date: | 2020-07-15 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (6.4 Å) | | Cite: | The architecture of EMC reveals a path for membrane protein insertion.
Elife, 9, 2020
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2F61
 | | Crystal structure of partially deglycosylated acid beta-glucosidase | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid beta-glucosidase, ... | | Authors: | Hegde, R.S, Grabowski, G. | | Deposit date: | 2005-11-28 | | Release date: | 2005-12-27 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Analyses of Variant Acid beta-Glucosidases: EFFECTS OF GAUCHER DISEASE MUTATIONS.
J.Biol.Chem., 281, 2006
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6HCM
 | | Structure of the rabbit collided di-ribosome (stalled monosome) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | | Authors: | Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2018-08-15 | | Release date: | 2018-10-17 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (6.8 Å) | | Cite: | ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Mol. Cell, 72, 2018
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8BPO
 | | Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (TTC5) and S-phase Cyclin A Associated Protein residing in the ER (SCAPER) | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Hopfler, M, Absmeier, E, Passmore, L.A, Hegde, R.S. | | Deposit date: | 2022-11-17 | | Release date: | 2023-07-05 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation.
Mol.Cell, 83, 2023
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5LZU
 | | Structure of the mammalian ribosomal termination complex with accommodated eRF1 | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | | Authors: | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2016-10-02 | | Release date: | 2016-11-30 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
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3JAJ
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3JC2
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3ZQ6
 | | ADP-ALF4 COMPLEX OF M. THERM. TRC40 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Sherrill, J, Mariappan, M, Dominik, P, Hegde, R.S, Keenan, R.J. | | Deposit date: | 2011-06-08 | | Release date: | 2011-06-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.107 Å) | | Cite: | A Conserved Archaeal Pathway for Tail-Anchored Membrane Protein Insertion.
Traffic, 12, 2011
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3ZS8
 | | S. cerevisiae Get3 complexed with a cytosolic Get1 fragment | | Descriptor: | ATPASE GET3, GOLGI TO ER TRAFFIC PROTEIN 1, ZINC ION | | Authors: | Mariappan, M, Mateja, A, Dobosz, M, Bove, E, Hegde, R.S, Keenan, R.J. | | Deposit date: | 2011-06-24 | | Release date: | 2011-09-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The Mechanism of Membrane-Associated Steps in Tail-Anchored Protein Insertion.
Nature, 477, 2011
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3ZS9
 | | S. cerevisiae Get3-ADP-AlF4- complex with a cytosolic Get2 fragment | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATPASE GET3, GOLGI TO ER TRAFFIC PROTEIN 2, ... | | Authors: | Mariappan, M, Mateja, A, Dobosz, M, Bove, E, Hegde, R.S, Keenan, R.J. | | Deposit date: | 2011-06-24 | | Release date: | 2011-09-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.095 Å) | | Cite: | The Mechanism of Membrane-Associated Steps in Tail-Anchored Protein Insertion.
Nature, 477, 2011
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423D
 | | 5'-D(*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3' | | Descriptor: | DNA (5'-D(*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3'), MAGNESIUM ION | | Authors: | Rozenberg, H, Rabinovich, D, Frolow, F, Hegde, R.S, Shakked, Z. | | Deposit date: | 1998-09-14 | | Release date: | 1999-10-14 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural code for DNA recognition revealed in crystal structures of papillomavirus E2-DNA targets.
Proc.Natl.Acad.Sci.USA, 95, 1998
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5LZT
 | | Structure of the mammalian ribosomal termination complex with eRF1 and eRF3. | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2016-10-02 | | Release date: | 2016-11-30 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
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5LZS
 | | Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B | | Descriptor: | (2~{S})-~{N}-[(2~{R})-1-[[(3~{S},6~{S},8~{S},12~{S},13~{R},16~{S},17~{R},20~{S},23~{S})-13-[(2~{S})-butan-2-yl]-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-12-oxidanyl-2,5,7,10,15,19,22-heptakis(oxidanylidene)-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-~{N}-methyl-1-[(2~{S})-2-oxidanylpropanoyl]pyrrolidine-2-carboxamide, 18S ribosomal RNA, 28S ribosomal RNA, ... | | Authors: | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2016-10-02 | | Release date: | 2016-11-30 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
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6HCF
 | | Structure of the rabbit 80S ribosome stalled on globin mRNA at the stop codon | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | | Authors: | Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2018-08-14 | | Release date: | 2018-10-17 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Mol. Cell, 72, 2018
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6HCQ
 | | Structure of the rabbit collided di-ribosome (collided monosome) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | | Authors: | Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2018-08-16 | | Release date: | 2018-10-17 | | Last modified: | 2018-11-14 | | Method: | ELECTRON MICROSCOPY (6.5 Å) | | Cite: | ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Mol. Cell, 72, 2018
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6HCJ
 | | Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | | Authors: | Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2018-08-15 | | Release date: | 2018-10-17 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Mol. Cell, 72, 2018
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6SGC
 | | Rabbit 80S ribosome stalled on a poly(A) tail | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | | Authors: | Chandrasekaran, V, Juszkiewicz, S, Choi, J, Puglisi, J.D, Brown, A, Shao, S, Ramakrishnan, V, Hegde, R.S. | | Deposit date: | 2019-08-03 | | Release date: | 2019-12-04 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of ribosome stalling during translation of a poly(A) tail.
Nat.Struct.Mol.Biol., 26, 2019
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6T59
 | | Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 and nascent chain-associated complex | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Lin, Z, Gasic, I, Chandrasekaran, V, Peters, N, Shao, S, Ramakrishnan, V, Mitchison, T.J, Hegde, R.S. | | Deposit date: | 2019-10-15 | | Release date: | 2019-11-27 | | Last modified: | 2020-01-15 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | TTC5 mediates autoregulation of tubulin via mRNA degradation.
Science, 367, 2020
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7TM3
 | | Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | | Deposit date: | 2022-01-19 | | Release date: | 2022-10-19 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Mechanism of an intramembrane chaperone for multipass membrane proteins.
Nature, 611, 2022
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7TUT
 | | Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon | | Descriptor: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Kim, M.K, Lewis, A.J.O, Keenan, R.J, Hegde, R.S. | | Deposit date: | 2022-02-03 | | Release date: | 2022-10-19 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | Mechanism of an intramembrane chaperone for multipass membrane proteins.
Nature, 611, 2022
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4XTR
 | | Structure of Get3 bound to the transmembrane domain of Pep12 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase GET3, ... | | Authors: | Mateja, A, Paduch, M, Chang, H.-Y, Szydlowska, A, Kossiakoff, A.A, Hegde, R.S, Keenan, R.J. | | Deposit date: | 2015-01-23 | | Release date: | 2015-03-18 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
Science, 347, 2015
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