5V8I
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![BU of 5v8i by Molmil](/molmil-images/mine/5v8i) | Thermus thermophilus 70S ribosome lacking ribosomal protein uS17 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Gregory, S.T, Jogl, G. | Deposit date: | 2017-03-22 | Release date: | 2018-03-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structural robustness of the ribosome inferred from X-ray crystal structures of the 30S ribosomal subunit and the 70S ribosome lacking ribosomal protein uS17 To be published
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3G8B
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![BU of 3g8b by Molmil](/molmil-images/mine/3g8b) | T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222 | Descriptor: | Ribosomal RNA small subunit methyltransferase G, S-ADENOSYLMETHIONINE, SULFATE ION | Authors: | Demirci, H, Gregory, S.T, Belardinelli, R, Gualerzi, C, Dahlberg, A.E, Jogl, G. | Deposit date: | 2009-02-11 | Release date: | 2009-06-30 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG Rna, 15, 2009
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3G89
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![BU of 3g89 by Molmil](/molmil-images/mine/3g89) | T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet and AMP in space group P61 | Descriptor: | ADENOSINE MONOPHOSPHATE, Ribosomal RNA small subunit methyltransferase G, S-ADENOSYLMETHIONINE | Authors: | Demirci, H, Gregory, S.T, Belardinelli, R, Gualerzi, C, Dahlberg, A.E, Jogl, G. | Deposit date: | 2009-02-11 | Release date: | 2009-06-30 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG Rna, 15, 2009
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3G88
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![BU of 3g88 by Molmil](/molmil-images/mine/3g88) | T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group P61 | Descriptor: | DI(HYDROXYETHYL)ETHER, Ribosomal RNA small subunit methyltransferase G, S-ADENOSYLMETHIONINE | Authors: | Demirci, H, Belardinelli, R, Gregory, S.T, Gualerzi, C, Dahlberg, A.E, Jogl, G. | Deposit date: | 2009-02-11 | Release date: | 2009-06-30 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG Rna, 15, 2009
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3G8A
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![BU of 3g8a by Molmil](/molmil-images/mine/3g8a) | T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoHcy in space group P61 | Descriptor: | Ribosomal RNA small subunit methyltransferase G, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Demirci, H, Gregory, S.T, Belardinelli, R, Gualerzi, C, Dahlberg, A.E, Jogl, G. | Deposit date: | 2009-02-11 | Release date: | 2009-06-30 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG Rna, 15, 2009
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6XHX
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![BU of 6xhx by Molmil](/molmil-images/mine/6xhx) | Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Svetlov, M.S, Syroegin, E.A, Aleksandrova, E.V, Atkinson, G.C, Gregory, S.T, Mankin, A.S, Polikanov, Y.S. | Deposit date: | 2020-06-19 | Release date: | 2020-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat.Chem.Biol., 17, 2021
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6XHY
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![BU of 6xhy by Molmil](/molmil-images/mine/6xhy) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Svetlov, M.S, Syroegin, E.A, Aleksandrova, E.V, Atkinson, G.C, Gregory, S.T, Mankin, A.S, Polikanov, Y.S. | Deposit date: | 2020-06-19 | Release date: | 2020-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat.Chem.Biol., 17, 2021
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6XHV
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![BU of 6xhv by Molmil](/molmil-images/mine/6xhv) | Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Svetlov, M.S, Syroegin, E.A, Aleksandrova, E.V, Atkinson, G.C, Gregory, S.T, Mankin, A.S, Polikanov, Y.S. | Deposit date: | 2020-06-19 | Release date: | 2020-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat.Chem.Biol., 17, 2021
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6XHW
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![BU of 6xhw by Molmil](/molmil-images/mine/6xhw) | Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Svetlov, M.S, Syroegin, E.A, Aleksandrova, E.V, Atkinson, G.C, Gregory, S.T, Mankin, A.S, Polikanov, Y.S. | Deposit date: | 2020-06-19 | Release date: | 2020-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat.Chem.Biol., 17, 2021
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3OTO
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![BU of 3oto by Molmil](/molmil-images/mine/3oto) | Crystal Structure of the 30S ribosomal subunit from a KsgA mutant of Thermus thermophilus (HB8) | Descriptor: | 16S rRNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ... | Authors: | Demirci, H, Murphy IV, F, Belardinelli, R, Kelley, A.C, Ramakrishnan, V, Gregory, S.T, Dahlberg, A.E, Jogl, G. | Deposit date: | 2010-09-13 | Release date: | 2010-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.69 Å) | Cite: | Modification of 16S ribosomal RNA by the KsgA methyltransferase restructures the 30S subunit to optimize ribosome function. Rna, 16, 2010
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8G2D
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![BU of 8g2d by Molmil](/molmil-images/mine/8g2d) | Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G29
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![BU of 8g29 by Molmil](/molmil-images/mine/8g29) | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2C
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![BU of 8g2c by Molmil](/molmil-images/mine/8g2c) | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2A
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![BU of 8g2a by Molmil](/molmil-images/mine/8g2a) | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2B
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![BU of 8g2b by Molmil](/molmil-images/mine/8g2b) | Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | Deposit date: | 2023-02-03 | Release date: | 2023-12-27 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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3M6W
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![BU of 3m6w by Molmil](/molmil-images/mine/3m6w) | Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group P21212 in complex with S-Adenosyl-L-Methionine | Descriptor: | CHLORIDE ION, S-ADENOSYLMETHIONINE, rRNA methylase | Authors: | Demirci, H, Larsen, H.G.L, Hansen, T, Rasmussen, A, Cadambi, A, Gregory, S.T, Kirpekar, F, Jogl, G. | Deposit date: | 2010-03-16 | Release date: | 2010-03-31 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Rna, 16, 2010
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3M6V
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![BU of 3m6v by Molmil](/molmil-images/mine/3m6v) | Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group P2 in complex with S-Adenosyl-L-Methionine | Descriptor: | S-ADENOSYLMETHIONINE, rRNA methylase | Authors: | Demirci, H, Larsen, H.G.L, Hansen, T, Rasmussen, A, Cadambi, A, Gregory, S.T, Kirpekar, F, Jogl, G. | Deposit date: | 2010-03-16 | Release date: | 2010-03-31 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Rna, 16, 2010
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3M6U
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![BU of 3m6u by Molmil](/molmil-images/mine/3m6u) | Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group 43 | Descriptor: | SULFATE ION, rRNA methylase | Authors: | Demirci, H, Larsen, H.G.L, Hansen, T, Rasmussen, A, Cadambi, A, Gregory, S.T, Kirpekar, F, Jogl, G. | Deposit date: | 2010-03-16 | Release date: | 2010-03-31 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.402 Å) | Cite: | Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Rna, 16, 2010
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3M6X
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![BU of 3m6x by Molmil](/molmil-images/mine/3m6x) | Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus in space group P21212 | Descriptor: | CHLORIDE ION, rRNA methylase | Authors: | Demirci, H, Larsen, H.G.L, Hansen, T, Rasmussen, A, Cadambi, A, Gregory, S.T, Kirpekar, F, Jogl, G. | Deposit date: | 2010-03-16 | Release date: | 2010-03-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.676 Å) | Cite: | Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. Rna, 16, 2010
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4NXN
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![BU of 4nxn by Molmil](/molmil-images/mine/4nxn) | Crystal Structure of the 30S ribosomal subunit from a GidB (RsmG) mutant of Thermus thermophilus (HB8), bound with streptomycin | Descriptor: | 16S rRNA, MAGNESIUM ION, STREPTOMYCIN, ... | Authors: | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | Deposit date: | 2013-12-09 | Release date: | 2014-05-21 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (3.544 Å) | Cite: | A structural basis for streptomycin resistance To be Published
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4NXM
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![BU of 4nxm by Molmil](/molmil-images/mine/4nxm) | Crystal Structure of the 30S ribosomal subunit from a GidB (RsmG) mutant of Thermus thermophilus (HB8) | Descriptor: | 16S rRNA, MAGNESIUM ION, ZINC ION, ... | Authors: | Demirci, H, Murphy IV, F, Murphy, E, Gregory, S.T, Dahlberg, A.E, Jogl, G. | Deposit date: | 2013-12-09 | Release date: | 2014-05-21 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | A structural basis for streptomycin resistance To be Published
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2NXC
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![BU of 2nxc by Molmil](/molmil-images/mine/2nxc) | |
2NXJ
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![BU of 2nxj by Molmil](/molmil-images/mine/2nxj) | |
2NXN
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![BU of 2nxn by Molmil](/molmil-images/mine/2nxn) | T. thermophilus ribosomal protein L11 methyltransferase (PrmA) in complex with ribosomal protein L11 | Descriptor: | 50S ribosomal protein L11, Ribosomal protein L11 methyltransferase | Authors: | Demirci, H, Gregory, S.T, Dahlberg, A.E, Jogl, G. | Deposit date: | 2006-11-17 | Release date: | 2006-12-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Recognition of ribosomal protein L11 by the protein trimethyltransferase PrmA. Embo J., 26, 2007
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2NXE
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![BU of 2nxe by Molmil](/molmil-images/mine/2nxe) | T. thermophilus ribosomal protein L11 methyltransferase (PrmA) in complex with S-Adenosyl-L-Methionine | Descriptor: | Ribosomal protein L11 methyltransferase, S-ADENOSYLMETHIONINE | Authors: | Demirci, H, Gregory, S.T, Dahlberg, A.E, Jogl, G. | Deposit date: | 2006-11-17 | Release date: | 2006-12-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Recognition of ribosomal protein L11 by the protein trimethyltransferase PrmA. Embo J., 26, 2007
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