6XHY

Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution

This is a non-PDB format compatible entry.

Summary for 6XHY

• Entry DOI: 10.2210/pdb6xhy/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (62 entities in total)
• Functional Keywords: macrolide; antibiotic; resistance; methylation; a2058; 23s rrna; 70s ribosome; x-ray structure; inhibition of translation; peptidyl transferase center; nascent peptide exit tunnel, ribosome
• Biological source: Escherichia coli; More
• Total number of polymer chains: 112
• Total formula weight: 4569690.77

Authors

Svetlov, M.S.,Syroegin, E.A.,Aleksandrova, E.V.,Atkinson, G.C.,Gregory, S.T.,Mankin, A.S.,Polikanov, Y.S. (deposition date: 2020-06-19, release date: 2020-12-23, Last modification date: 2023-11-15)

• Primary citation: Svetlov, M.S.,Syroegin, E.A.,Aleksandrova, E.V.,Atkinson, G.C.,Gregory, S.T.,Mankin, A.S.,Polikanov, Y.S.; Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.; Nat.Chem.Biol., 17:412-420, 2021; PubMed: 33462493; DOI: 10.1038/s41589-020-00715-0

Experimental method

X-RAY DIFFRACTION (2.6 Å)