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3EYV
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BU of 3eyv by Molmil
Anti-Lewis Y Fab fragment with Lewis Y antigen in the presence of zinc ions
Descriptor: GLYCEROL, ZINC ION, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-alpha-D-glucopyranose, ...
Authors:Farrugia, W, Scott, A.M, Ramsland, P.A.
Deposit date:2008-10-22
Release date:2009-11-03
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A possible role for metallic ions in the carbohydrate cluster recognition displayed by a lewis y specific antibody.
Plos One, 4, 2009
6BZ4
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BU of 6bz4 by Molmil
Human IgG1 lacking complement-dependent cytotoxicity: hu3S193 Fc mutant K322A
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Farrugia, W, Burvenich, I.G.J, Scott, A.M, Ramsland, P.A.
Deposit date:2017-12-22
Release date:2018-06-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions.
Biochem. J., 475, 2018
4WI8
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BU of 4wi8 by Molmil
Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation Y436A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose, ...
Authors:Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI2
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BU of 4wi2 by Molmil
Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc (wild-type)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region
Authors:Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI7
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BU of 4wi7 by Molmil
Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H435A
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region
Authors:Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI5
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BU of 4wi5 by Molmil
Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation H310A
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region
Authors:Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI3
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BU of 4wi3 by Molmil
Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region
Authors:Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI6
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BU of 4wi6 by Molmil
Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation N434A
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region
Authors:Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI4
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BU of 4wi4 by Molmil
Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation S254A
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region
Authors:Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
4WI9
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BU of 4wi9 by Molmil
Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation I253A/H310A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region, ...
Authors:Farrugia, W, Burvenich, I.J.G, Scott, A.M, Ramsland, P.A.
Deposit date:2014-09-25
Release date:2015-09-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural and functional mapping of human IgG1 binding site for FcRn in vivo using human FcRn transgenic mice
To Be Published
2QEJ
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BU of 2qej by Molmil
Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ...
Authors:Ramsland, P.A, Willoughby, N, Trist, H.M, Farrugia, W, Hogarth, P.M, Fraser, J.D, Wines, B.D.
Deposit date:2007-06-26
Release date:2007-09-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1
Proc.Natl.Acad.Sci.Usa, 104, 2007
2AGJ
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BU of 2agj by Molmil
Crystal Structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Yvo Fab, Heavy Chain, ...
Authors:Ramsland, P.A, Terzyan, S.S, Cloud, G, Bourne, C.R, Farrugia, W, Tribbick, G, Geysen, H.M, Moomaw, C.R, Slaughter, C.A, Edmundson, A.B.
Deposit date:2005-07-27
Release date:2006-05-02
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody
Biochem.J., 395, 2006
3RY5
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BU of 3ry5 by Molmil
Three-dimensional structure of glycosylated fcgammariia (high-responder polymorphism)
Descriptor: LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-A
Authors:Ramsland, P.A, Farrugia, W, Hogarth, P.M.
Deposit date:2011-05-11
Release date:2011-08-31
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Fc{gamma}RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes.
J.Immunol., 187, 2011
1S3K
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BU of 1s3k by Molmil
Crystal Structure of a Humanized Fab (hu3S193) in Complex with the Lewis Y Tetrasaccharide
Descriptor: GLYCEROL, HU3S193 Fab fragment, heavy chain, ...
Authors:Ramsland, P.A, Farrugia, W, Bradford, T.M, Hogarth, P.M, Scott, A.M.
Deposit date:2004-01-13
Release date:2004-07-13
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural convergence of antibody binding of carbohydrate determinants in lewis y tumor antigens
J.Mol.Biol., 340, 2004
3RY6
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BU of 3ry6 by Molmil
Complex of fcgammariia (CD32) and the FC of human IGG1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ig gamma-1 chain C region, ...
Authors:Ramsland, P.A, Farrugia, W, Scott, A.M, Hogarth, P.M.
Deposit date:2011-05-11
Release date:2011-08-31
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Basis for Fc{gamma}RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes.
J.Immunol., 187, 2011
3RY4
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BU of 3ry4 by Molmil
1.5 Angstrom resolution structure of glycosylated fcgammariia (low-responder polymorphism)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Low affinity immunoglobulin gamma Fc region receptor II-a
Authors:Ramsland, P.A, Farrugia, W, Hogarth, P.M.
Deposit date:2011-05-11
Release date:2011-08-31
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for Fc{gamma}RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes.
J.Immunol., 187, 2011
2FO4
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BU of 2fo4 by Molmil
Enhanced MHC class I binding and immune responses through anchor modification of the non-canonical tumor associated MUC1-8 peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-mer from Mucin-1, ...
Authors:Lazoura, E, Ramsland, P.A.
Deposit date:2006-01-12
Release date:2006-11-14
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide
Immunology, 119, 2006

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数据于2024-11-06公开中

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