9G13
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9g13 by Molmil](/molmil-images/mine/9g13) | VHH H3-2 in complex with Tau C-terminal peptide | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau, VHH H3-2 | Authors: | Dupre, E, Landrieu, I, Danis, C, Hanoulle, X, Mortelecque, J. | Deposit date: | 2024-07-09 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | VHH H3-2 in complex with Tau C-terminal peptide To Be Published
|
|
4Q0C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q0c by Molmil](/molmil-images/mine/4q0c) | 3.1 A resolution crystal structure of the B. pertussis BvgS periplasmic domain | Descriptor: | Virulence sensor protein BvgS | Authors: | Dupre, E, Herrou, J, Lensink, M.F, Wintjens, R, Lebedev, A, Crosson, S, Villeret, V, Locht, C, Antoine, R, Jacob-Dubuisson, F. | Deposit date: | 2014-04-01 | Release date: | 2015-02-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Virulence Regulation with Venus Flytrap Domains: Structure and Function of the Periplasmic Moiety of the Sensor-Kinase BvgS. Plos Pathog., 11, 2015
|
|
7NTW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ntw by Molmil](/molmil-images/mine/7ntw) | |
7NTT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ntt by Molmil](/molmil-images/mine/7ntt) | |
6ZJ8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zj8 by Molmil](/molmil-images/mine/6zj8) | |
8OP0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8op0 by Molmil](/molmil-images/mine/8op0) | VHH Z70 mutant 20 in interaction with PHF6 Tau peptide | Descriptor: | Tau PHF6 peptide, VHH Z70 mutant 20 | Authors: | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | Deposit date: | 2023-04-06 | Release date: | 2023-05-31 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein. J.Biol.Chem., 300, 2024
|
|
8PII
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pii by Molmil](/molmil-images/mine/8pii) | VHH Z70 mutant 3 in interaction with PHF6 Tau peptide | Descriptor: | Microtubule-associated protein tau, VHH Z70 Mutant 3 | Authors: | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | Deposit date: | 2023-06-21 | Release date: | 2023-07-05 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein. J.Biol.Chem., 300, 2024
|
|
8OPI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8opi by Molmil](/molmil-images/mine/8opi) | VHH Z70 mutant 1 in interaction with PHF6 Tau peptide | Descriptor: | PHF6 Tau peptide, VHH Z70 mutant 1 | Authors: | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | Deposit date: | 2023-04-07 | Release date: | 2023-05-31 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein. J.Biol.Chem., 300, 2024
|
|
7NTQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ntq by Molmil](/molmil-images/mine/7ntq) | Crystal structure of the SARS-CoV-2 Main Protease complexed with N-(pyridin-3-ylmethyl)thioformamide | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE, FORMIC ACID, ... | Authors: | Dupre, E, Villeret, V, Hanoulle, X. | Deposit date: | 2021-03-10 | Release date: | 2022-03-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.495 Å) | Cite: | Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses. Eur.J.Med.Chem., 250, 2023
|
|
3MPK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mpk by Molmil](/molmil-images/mine/3mpk) | Crystal Structure of Bordetella pertussis BvgS periplasmic VFT2 domain | Descriptor: | ACETATE ION, GLYCEROL, Virulence sensor protein bvgS | Authors: | Herrou, J, Bompard, C, Wintjens, R, Dupre, E, Willery, E, Villeret, V, Locht, C, Antoine, R, Jacob-Dubuisson, F. | Deposit date: | 2010-04-27 | Release date: | 2010-10-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3MPL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mpl by Molmil](/molmil-images/mine/3mpl) | Crystal Structure of Bordetella pertussis BvgS VFT2 domain (Double Mutant F375E/Q461E) | Descriptor: | 1,2-ETHANEDIOL, Virulence sensor protein bvgS | Authors: | Herrou, J, Bompard, C, Wintjens, R, Dupre, E, Willery, E, Villeret, V, Locht, C, Antoine, R, Jacob-Dubuisson, F. | Deposit date: | 2010-04-27 | Release date: | 2010-10-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
7QCQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qcq by Molmil](/molmil-images/mine/7qcq) | VHH Z70 in interaction with PHF6 Tau peptide | Descriptor: | GLYCEROL, Tau 301-312, VHH Z70 | Authors: | Danis, C, Dupre, E, Zejneli, O, Caillierez, R, Arrial, A, Begard, S, Loyens, A, Mortelecque, J, Cantrelle, F.-X, Hanoulle, X, Rain, J.-C, Colin, M, Buee, L, Landrieu, I. | Deposit date: | 2021-11-25 | Release date: | 2021-12-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment. Mol.Ther., 30, 2022
|
|
7NLC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nlc by Molmil](/molmil-images/mine/7nlc) | Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide | Descriptor: | AMMONIUM ION, CHLORIDE ION, Protein ORF3, ... | Authors: | Moschidi, D, Dupre, E, Villeret, V, Hanoulle, X. | Deposit date: | 2021-02-22 | Release date: | 2022-03-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.398 Å) | Cite: | Crystallographic structure of human Tsg101 UEV domain in complex with a HEV ORF3 peptide To Be Published
|
|
7NTS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nts by Molmil](/molmil-images/mine/7nts) | Crystal structure of the SARS-CoV-2 Main Protease with oxidized C145 | Descriptor: | DIMETHYL SULFOXIDE, FORMIC ACID, GLYCEROL, ... | Authors: | Dupre, E, Villeret, V, Hanoulle, X. | Deposit date: | 2021-03-10 | Release date: | 2021-10-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.477 Å) | Cite: | NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|
8AEB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8aeb by Molmil](/molmil-images/mine/8aeb) | SARS-CoV-2 Main Protease complexed with N-(pyridin-3-ylmethyl)thioformamide | Descriptor: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, N-(pyridin-3-ylmethyl)thioformamide, ... | Authors: | Hanoulle, X, Charton, J, Deprez, B. | Deposit date: | 2022-07-12 | Release date: | 2023-03-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses. Eur.J.Med.Chem., 250, 2023
|
|
4QKY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qky by Molmil](/molmil-images/mine/4qky) | Crystal Structure Analysis of the Membrane Transporter FhaC | Descriptor: | Filamentous hemagglutinin transporter protein FhaC, PHOSPHATE ION | Authors: | Maier, T, Clantin, B, Gruss, F, Dewitte, F, Delattre, A.S, Jacob-Dubuisson, F, Hiller, S, Villeret, V. | Deposit date: | 2014-06-10 | Release date: | 2014-10-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Conserved Omp85 lid-lock structure and substrate recognition in FhaC Nat Commun, 6, 2015
|
|