7QCQ

VHH Z70 in interaction with PHF6 Tau peptide

This is a non-PDB format compatible entry.

Summary for 7QCQ

• Entry DOI: 10.2210/pdb7qcq/pdb
• Descriptor: VHH Z70, Tau 301-312, GLYCEROL, ... (4 entities in total)
• Functional Keywords: nanobody, vhh, tau, phf6, immune system
• Biological source: Lama glama; More
• Total number of polymer chains: 2
• Total formula weight: 16117.72

Authors

Danis, C.,Dupre, E.,Zejneli, O.,Caillierez, R.,Arrial, A.,Begard, S.,Loyens, A.,Mortelecque, J.,Cantrelle, F.-X.,Hanoulle, X.,Rain, J.-C.,Colin, M.,Buee, L.,Landrieu, I. (deposition date: 2021-11-25, release date: 2021-12-08, Last modification date: 2024-01-31)

• Primary citation: Danis, C.,Dupre, E.,Zejneli, O.,Caillierez, R.,Arrial, A.,Begard, S.,Mortelecque, J.,Eddarkaoui, S.,Loyens, A.,Cantrelle, F.X.,Hanoulle, X.,Rain, J.C.,Colin, M.,Buee, L.,Landrieu, I.; Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.; Mol.Ther., 30:1484-1499, 2022; PubMed: 35007758; DOI: 10.1016/j.ymthe.2022.01.009

Experimental method

X-RAY DIFFRACTION (1.7 Å)