6DMC
| ppGpp Riboswitch bound to ppGpp, native structure | Descriptor: | GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Peselis, A, Serganov, A. | Deposit date: | 2018-06-04 | Release date: | 2018-11-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands. Nat. Chem. Biol., 14, 2018
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6DMD
| ppGpp Riboswitch bound to ppGpp, manganese chloride structure | Descriptor: | GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, MANGANESE (II) ION, ... | Authors: | Peselis, A, Serganov, A. | Deposit date: | 2018-06-05 | Release date: | 2018-11-14 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands. Nat. Chem. Biol., 14, 2018
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6DNR
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6DLQ
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6DLT
| PRPP Riboswitch bound to PRPP, native structure | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, PRPP Riboswitch, ... | Authors: | Peselis, A, Serganov, A. | Deposit date: | 2018-06-02 | Release date: | 2018-11-14 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands. Nat. Chem. Biol., 14, 2018
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6DLS
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6DME
| ppGpp Riboswitch bound to ppGpp, thallium acetate structure | Descriptor: | GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, THALLIUM (I) ION, ... | Authors: | Peselis, A, Serganov, A. | Deposit date: | 2018-06-05 | Release date: | 2018-11-14 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands. Nat. Chem. Biol., 14, 2018
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6DLR
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4GXY
| RNA structure | Descriptor: | Adenosylcobalamin, Adenosylcobalamin riboswitch, IRIDIUM HEXAMMINE ION, ... | Authors: | Serganov, A, Peselis, A. | Deposit date: | 2012-09-04 | Release date: | 2012-10-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch. Nat.Struct.Mol.Biol., 19, 2012
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5DDP
| L-glutamine riboswitch bound with L-glutamine | Descriptor: | GLUTAMINE, MAGNESIUM ION, RNA (61-MER), ... | Authors: | Ren, A, Patel, D.J. | Deposit date: | 2015-08-25 | Release date: | 2015-12-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Rep, 13, 2015
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5DDO
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5DDQ
| L-glutamine riboswitch bound with L-glutamine soaked with Mn2+ | Descriptor: | GLUTAMINE, L-glutamine riboswitch RNA (61-MER), MAGNESIUM ION, ... | Authors: | Ren, A, Patel, D.J. | Deposit date: | 2015-08-25 | Release date: | 2015-12-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Rep, 13, 2015
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5DDR
| L-glutamine riboswitch bound with L-glutamine soaked with Cs+ | Descriptor: | CESIUM ION, GLUTAMINE, L-glutamine riboswitch RNA (61-MER), ... | Authors: | Ren, A, Patel, D.J. | Deposit date: | 2015-08-25 | Release date: | 2015-12-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.605 Å) | Cite: | Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Rep, 13, 2015
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7MCB
| Crystal structure of Staphylococcus aureus Cystathionine gamma lyase Holoenzyme | Descriptor: | Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-01 | Release date: | 2021-06-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MCP
| Crystal structure of Staphylococcus aureus Cystathionine gamma-lyase, Holoenzyme dimer | Descriptor: | Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-02 | Release date: | 2021-06-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MD6
| Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103N mutant co-crystallized with NL1 | Descriptor: | Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, CITRATE ANION, N-[(6-bromo-1H-indol-1-yl)acetyl]glycine, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-03 | Release date: | 2021-06-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MDB
| Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103A mutant co-crystallized with NL2 | Descriptor: | 5-[(6-bromo-1H-indol-1-yl)methyl]-2-methylfuran-3-carboxylic acid, Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, CACODYLATE ION, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-03 | Release date: | 2021-06-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MCN
| Crystal structure of Staphylococcus aureus Cystathionine gamma-lyase, Holoenzyme with High HEPES | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, GLYCEROL, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-02 | Release date: | 2021-06-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MD9
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7MD1
| Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103N mutant | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, GLYCEROL, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-02 | Release date: | 2021-06-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MCQ
| Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, AOAA-bound enzyme in dimeric form | Descriptor: | 4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE, Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, GLYCEROL, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-02 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MCT
| Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, Holoenzyme with bound NL1 | Descriptor: | Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, GLYCEROL, N-[(6-bromo-1H-indol-1-yl)acetyl]glycine, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-02 | Release date: | 2021-06-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MD0
| Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme in the presence of NL1F3 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, GLYCEROL, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-02 | Release date: | 2021-06-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MCL
| Crystal structure of Staphylococcus aureus Cystathionine gamma-lyase, PLP bound | Descriptor: | Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-02 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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7MCY
| Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, Holoenzyme with bound NL3 | Descriptor: | 3-{[6-(7-chloro-1-benzothiophen-2-yl)-1H-indol-1-yl]methyl}-1H-pyrazole-5-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, ... | Authors: | Nuthanakanti, A, Serganov, A, Kaushik, A. | Deposit date: | 2021-04-02 | Release date: | 2021-06-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
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