4GXY
RNA structure
Summary for 4GXY
| Entry DOI | 10.2210/pdb4gxy/pdb |
| Descriptor | Adenosylcobalamin riboswitch, Adenosylcobalamin, IRIDIUM HEXAMMINE ION, ... (5 entities in total) |
| Functional Keywords | rna, riboswitch, adenosylcobalamin |
| Total number of polymer chains | 1 |
| Total formula weight | 61457.90 |
| Authors | Serganov, A.,Peselis, A. (deposition date: 2012-09-04, release date: 2012-10-17, Last modification date: 2024-02-28) |
| Primary citation | Peselis, A.,Serganov, A. Structural insights into ligand binding and gene expression control by an adenosylcobalamin riboswitch. Nat.Struct.Mol.Biol., 19:1182-1184, 2012 Cited by PubMed Abstract: Coenzyme B(12) has a key role in various enzymatic reactions and controls expression of bacterial genes through riboswitches. Here we report the crystal structure of the Symbiobacterium thermophilum B(12) riboswitch bound to its ligand adenosylcobalamin. The riboswitch forms a unique junctional structure with a large ligand-binding pocket tailored for specific recognition of the adenosyl moiety and flanked by structural elements that stabilize the regulatory region and enable control of gene expression. PubMed: 23064646DOI: 10.1038/nsmb.2405 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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