7MCP

Crystal structure of Staphylococcus aureus Cystathionine gamma-lyase, Holoenzyme dimer

Summary for 7MCP

Entry DOI	10.2210/pdb7mcp/pdb
Descriptor	Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, PYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... (5 entities in total)
Functional Keywords	amino-acid biosynthesis, cysteine biosynthesis, hydrogen sulfide production, plp dependent enzyme, lyase
Biological source	Staphylococcus aureus
Total number of polymer chains	2
Total formula weight	84020.02
Authors	Nuthanakanti, A.,Serganov, A.,Kaushik, A. (deposition date: 2021-04-02, release date: 2021-06-23, Last modification date: 2023-11-15)
Primary citation	Shatalin, K.,Nuthanakanti, A.,Kaushik, A.,Shishov, D.,Peselis, A.,Shamovsky, I.,Pani, B.,Lechpammer, M.,Vasilyev, N.,Shatalina, E.,Rebatchouk, D.,Mironov, A.,Fedichev, P.,Serganov, A.,Nudler, E. Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372:1169-1175, 2021 Cited by PubMed: 34112687 DOI: 10.1126/science.abd8377 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation