4FMW
| Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2 | Descriptor: | 1,2-ETHANEDIOL, POTASSIUM ION, RNA (guanine-9-)-methyltransferase domain-containing protein 2, ... | Authors: | Dong, A, Zeng, H, Loppnau, P, Tempel, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-06-18 | Release date: | 2012-08-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2 TO BE PUBLISHED
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2FDH
| Crystal Structure of AlkB in complex with Mn(II), 2-oxoglutarate, and methylated trinucleotide T-meA-T | Descriptor: | 2-OXOGLUTARIC ACID, 5'-D(P*TP*(MA7)P*T)-3', Alkylated DNA repair protein alkB, ... | Authors: | Yu, B, Benach, J, Edstrom, W.C, Gibney, B.R, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-12-14 | Release date: | 2006-02-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature, 439, 2006
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4FJW
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1ZBP
| X-Ray Crystal Structure of Protein VPA1032 from Vibrio parahaemolyticus. Northeast Structural Genomics Consortium Target VpR44 | Descriptor: | hypothetical protein VPA1032 | Authors: | Forouhar, F, Yong, W, Vorobiev, S.M, Ciao, M, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-04-08 | Release date: | 2005-04-19 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Functional insights from structural genomics. J.STRUCT.FUNCT.GENOM., 8, 2007
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2Z76
| X-ray crystal structure of RV0760c from Mycobacterium tuberculosis at 1.82 Angstrom resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, LAURYL DIMETHYLAMINE-N-OXIDE, ... | Authors: | Cherney, M.M, Garen, C.R, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2007-08-16 | Release date: | 2007-09-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structure of Mycobacterium tuberculosis Rv0760c at 1.50 A resolution, a structural homolog of Delta(5)-3-ketosteroid isomerase. Biochim.Biophys.Acta, 1784, 2008
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3O8V
| Crystal Structure of the Tudor Domains from FXR1 | Descriptor: | Fragile X mental retardation syndrome-related protein 1 | Authors: | Lam, R, Guo, Y.H, Adams-Cioaba, M, Bian, C.B, Mackenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2010-08-03 | Release date: | 2010-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2. Plos One, 5, 2010
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2FK9
| Human protein kinase C, eta | Descriptor: | protein kinase C, eta type | Authors: | Walker, J.R, Littler, D.R, Finerty Jr, P.J, MacKenzie, F, Newman, E.M, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-01-04 | Release date: | 2006-01-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites. Biochem.Biophys.Res.Commun., 349, 2006
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2EWS
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2F8A
| Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1 | Descriptor: | Glutathione peroxidase 1, MALONIC ACID | Authors: | Kavanagh, K.L, Johansson, C, Smee, C, Gileadi, O, von Delft, F, Weigelt, J, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2005-12-02 | Release date: | 2005-12-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1 To be Published
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2EXE
| Crystal structure of the phosphorylated CLK3 | Descriptor: | Dual specificity protein kinase CLK3 | Authors: | Papagrigoriou, E, Rellos, P, Das, S, Bullock, A, Ball, L.J, Turnbull, A, Savitsky, P, Fedorov, O, Johansson, C, Ugochukwu, E, Sobott, F, von Delft, F, Edwards, A, Sundstrom, M, Weigelt, J, Arrowsmith, C, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2005-11-08 | Release date: | 2005-11-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of the phosphorylated CLK3 TO BE PUBLISHED
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2EW1
| Crystal Structure of Rab30 in complex with a GTP analogue | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-30 | Authors: | Wang, J, Shen, Y, Ismail, S, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC) | Deposit date: | 2005-11-01 | Release date: | 2005-11-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of RAB30 in complex with a GTP analogue To be Published
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4ER6
| Crystal structure of human DOT1L in complex with inhibitor SGC0946 | Descriptor: | 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, BROMIDE ION, Histone-lysine N-methyltransferase, ... | Authors: | Wernimont, A.K, Tempel, W, Yu, W, Scopton, A, Li, Y, Nguyen, K.T, Vedadi, M, Bradner, J.E, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brown, P.J, Structural Genomics Consortium (SGC) | Deposit date: | 2012-04-19 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun, 3, 2012
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2QGQ
| Crystal structure of TM_1862 from Thermotoga maritima. Northeast Structural Genomics Consortium target VR77 | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Protein TM_1862 | Authors: | Forouhar, F, Neely, H, Hussain, M, Seetharaman, J, Fang, Y, Chen, C.X, Cunningham, K, Conover, K, Ma, L.-C, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-06-29 | Release date: | 2007-07-17 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Post-translational Modification of Ribosomal Proteins: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF RimO FROM THERMOTOGA MARITIMA, A RADICAL S-ADENOSYLMETHIONINE METHYLTHIOTRANSFERASE. J.Biol.Chem., 285, 2010
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3CQV
| Crystal structure of Reverb beta in complex with heme | Descriptor: | Nuclear receptor subfamily 1 group D member 2, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Xu, X, Dong, A, Pardee, K.I, Reinking, J, Krause, H, Schuetz, A, Zhang, R, Cui, H, Edwards, A, Arrowsmith, C.H, Weigelt, J, Bountra, C, Savchenko, A, Botchkarev, A, Structural Genomics Consortium (SGC) | Deposit date: | 2008-04-03 | Release date: | 2008-08-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta. Plos Biol., 7, 2009
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2F6Q
| The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Peroxisomal 3,2-trans-enoyl-CoA isomerase | Authors: | Turnbull, A, Lukacik, P, Shafqat, N, Smee, C, Berridge, G, Guo, K, von Delft, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Gileadi, O, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2005-11-29 | Release date: | 2005-12-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI) To be Published
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4FND
| Crystal structure of the Mtb enoyl CoA isomerase in complex with hydroxyhexanoyl CoA | Descriptor: | (S)-3-Hydroxyhexanoyl-CoA, Enoyl-CoA hydratase/isomerase family protein, SULFATE ION | Authors: | Bruning, J.B, Gao, N, Hernandez, E.D, Li, H, Dang, N, Hung, L.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-06-19 | Release date: | 2013-05-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure and mechanism of the prokaryotic enoyl CoA isomerase To be Published
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4FOG
| Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid | Descriptor: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, Thymidylate synthase | Authors: | Reddy, M.C.M, Bruning, J.B, Harshbarger, W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-06-20 | Release date: | 2013-08-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition To be Published
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2ERY
| The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein R-Ras2 | Authors: | Salah, E, Schoch, G, Turnbull, A, Papagrigoriou, E, Soundararajan, M, Burgess, N, Elkins, J, Gileadi, C, Gileadi, O, von Delft, F, Edwards, A, Arrowsmith, C, Weigelt, J, Sundstrom, M, Doyle, D, Structural Genomics Consortium (SGC) | Deposit date: | 2005-10-25 | Release date: | 2005-11-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state To be Published
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4FOX
| Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | Authors: | Reddy, M.C.M, Bruning, J.B, Sacchettini, J.C, Harshbarger, W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-06-21 | Release date: | 2013-08-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition To be Published
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2FDJ
| Crystal Structure of AlkB in complex with Fe(II) and succinate | Descriptor: | Alkylated DNA repair protein alkB, FE (II) ION, SUCCINIC ACID | Authors: | Yu, B, Benach, J, Edstrom, W.C, Gibney, B.R, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-12-14 | Release date: | 2006-02-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature, 439, 2006
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2FDF
| Crystal Structure of AlkB in complex with Co(II), 2-oxoglutarate, and methylated trinucleotide T-meA-T | Descriptor: | 2-OXOGLUTARIC ACID, 5'-D(P*TP*(MA7)P*T)-3', Alkylated DNA repair protein alkB, ... | Authors: | Yu, B, Benach, J, Edstrom, W.C, Gibney, B.R, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-12-13 | Release date: | 2006-02-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature, 439, 2006
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2FLS
| Crystal structure of Human Glutaredoxin 2 complexed with glutathione | Descriptor: | GLUTATHIONE, Glutaredoxin-2 | Authors: | Johansson, C, Smee, C, Kavanagh, K.L, Debreczeni, J, von Delft, F, Gileadi, O, Arrowsmith, C, Weigelt, J, Edwards, A, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) | Deposit date: | 2006-01-06 | Release date: | 2006-01-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of Human Glutaredoxin 2 complexed with glutathione To be Published
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2F7S
| The crystal structure of human Rab27b bound to GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-27B | Authors: | Wang, J, Ismail, S, Shen, Y, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC) | Deposit date: | 2005-12-01 | Release date: | 2005-12-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The crystal structure of human Rab27b To be Published
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2FDG
| Crystal Structure of AlkB in complex with Fe(II), succinate, and methylated trinucleotide T-meA-T | Descriptor: | 5'-D(P*TP*(MA7)P*T)-3', Alkylated DNA repair protein alkB, FE (II) ION, ... | Authors: | Yu, B, Benach, J, Edstrom, W.C, Gibney, B.R, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-12-13 | Release date: | 2006-02-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature, 439, 2006
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2FDI
| Crystal Structure of AlkB in complex with Fe(II), 2-oxoglutarate, and methylated trinucleotide T-meA-T (air 3 hours) | Descriptor: | 2-OXOGLUTARIC ACID, 5'-D(P*TP*(MA7)P*T)-3', Alkylated DNA repair protein alkB, ... | Authors: | Yu, B, Benach, J, Edstrom, W.C, Gibney, B.R, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2005-12-14 | Release date: | 2006-02-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature, 439, 2006
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