7OCJ
 
 | | Crystal structure of E.coli LexA in complex with nanobody NbSOS2(Nb14509) | | Descriptor: | 1,2-ETHANEDIOL, LexA repressor, NbSOS2 (14509) | | Authors: | Maso, L, Vascon, F, Chinellato, M, Pardon, E, Steyaert, J, Angelini, A, Tondi, D, Cendron, L. | | Deposit date: | 2021-04-27 | | Release date: | 2022-10-26 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway.
Structure, 30, 2022
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7RTH
 | | Crystal structure of an anti-lysozyme nanobody in complex with an anti-nanobody Fab "NabFab" | | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fragment Antigen-Binding Heavy Chain, ... | | Authors: | Filippova, E.V, Mukherjee, S, Bloch, J.S, Locher, K.P, Kossiakoff, A.A. | | Deposit date: | 2021-08-13 | | Release date: | 2021-09-01 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6VBG
 | | Lactose permease complex with thiodigalactoside and nanobody 9043 | | Descriptor: | Galactoside permease, beta-D-galactopyranose-(1-1)-1-thio-beta-D-galactopyranose, nanobody 9043, ... | | Authors: | Kumar, H, Stroud, R.M, Kaback, H.R, Finer-Moore, J, Smirnova, I, Kasho, V, Pardon, E, Steyart, J. | | Deposit date: | 2019-12-18 | | Release date: | 2020-11-25 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Diversity in kinetics correlated with structure in nano body-stabilized LacY.
Plos One, 15, 2020
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3K7U
 | | Structure of essential protein from Trypanosoma brucei | | Descriptor: | Antibody, MP18 RNA editing complex protein | | Authors: | Wu, M. | | Deposit date: | 2009-10-13 | | Release date: | 2010-11-17 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.
J.Struct.Biol., 174, 2011
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6F2W
 | | Bacterial asc transporter crystal structure in open to in conformation | | Descriptor: | ALPHA-AMINOISOBUTYRIC ACID, Nanobody 74, Putative amino acid/polyamine transport protein, ... | | Authors: | Fort, J, Errasti-Murugarren, E, Carpena, X, Palacin, M, Fita, I. | | Deposit date: | 2017-11-27 | | Release date: | 2019-04-24 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction.
Nat Commun, 10, 2019
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6F2G
 | | Bacterial asc transporter crystal structure in open to in conformation | | Descriptor: | Nanobody 74, Putative amino acid/polyamine transport protein, ZINC ION | | Authors: | Fort, J, Errasti-Murugarren, E, Carpena, X, Palacin, M, Fita, I. | | Deposit date: | 2017-11-24 | | Release date: | 2019-04-24 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.92 Å) | | Cite: | L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction.
Nat Commun, 10, 2019
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8QOT
 | | Structure of the mu opioid receptor bound to the antagonist nanobody NbE | | Descriptor: | Anti-Fab Nanobody, Mu-type opioid receptor, NabFab HC, ... | | Authors: | Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Manglik, A, Ballet, S, Boland, A, Stoeber, M. | | Deposit date: | 2023-09-29 | | Release date: | 2023-12-27 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of mu-opioid receptor targeting by a nanobody antagonist.
Nat Commun, 15, 2024
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6HEQ
 | | Prion nanobody 484 | | Descriptor: | Prion nanobody 484 | | Authors: | Soror, S.H, Abskharon, R.N, Wohlkonig, A. | | Deposit date: | 2018-08-20 | | Release date: | 2019-12-04 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.23 Å) | | Cite: | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion.
Plos Pathog., 15, 2019
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7MEZ
 | | Structure of the phosphoinositide 3-kinase p110 gamma (PIK3CG) p101 (PIK3R5) complex | | Descriptor: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 5 | | Authors: | Burke, J.E, Dalwadi, U, Rathinaswamy, M.K, Yip, C.K. | | Deposit date: | 2021-04-08 | | Release date: | 2021-07-14 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Structure of the phosphoinositide 3-kinase (PI3K) p110 gamma-p101 complex reveals molecular mechanism of GPCR activation.
Sci Adv, 7, 2021
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8T60
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3STB
 | | A complex of two editosome proteins and two nanobodies | | Descriptor: | MP18 RNA editing complex protein, RNA-editing complex protein MP42, single domain antibody VHH | | Authors: | Park, Y.-J, Hol, W. | | Deposit date: | 2011-07-09 | | Release date: | 2011-11-02 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody.
Nucleic Acids Res., 40, 2012
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7GSP
 | | RIBONUCLEASE T1/2',3'-CGPS, NON-PRODUCTIVE | | Descriptor: | GUANOSINE-2',3'-CYCLOPHOSPHOROTHIOATE, PHOSPHATE ION, RIBONUCLEASE T1 | | Authors: | Zegers, I, Wyns, L. | | Deposit date: | 1997-12-10 | | Release date: | 1998-03-18 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography.
Nat.Struct.Biol., 5, 1998
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7EH3
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7PIJ
 | | Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | | Descriptor: | Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ... | | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | | Deposit date: | 2021-08-20 | | Release date: | 2021-09-01 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7PHQ
 | | Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | | Descriptor: | Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ... | | Authors: | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | | Deposit date: | 2021-08-18 | | Release date: | 2021-09-01 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (8.45 Å) | | Cite: | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
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8CQB
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5M7M
 | | Novel Imidazo[1,2-a]pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity | | Descriptor: | CHLORIDE ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, IODIDE ION, ... | | Authors: | Wolhkoning, A, Fleury, D, Leonard, P, Triballeau, N, Mollat, P, Vercheval, L. | | Deposit date: | 2016-10-28 | | Release date: | 2017-08-30 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.
J. Med. Chem., 60, 2017
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3OSS
 | | The crystal structure of enterotoxigenic Escherichia coli GspC-GspD complex from the type II secretion system | | Descriptor: | CALCIUM ION, CHLORIDE ION, TYPE 2 SECRETION SYSTEM, ... | | Authors: | Korotkov, K.V, Pruneda, J, Hol, W.G.J. | | Deposit date: | 2010-09-09 | | Release date: | 2011-08-03 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Structural and functional studies on the interaction of GspC and GspD in the type II secretion system.
Plos Pathog., 7, 2011
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7SPA
 | | Chlorella virus Hyaluronan Synthase in the GlcNAc-primed, channel-open state | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | Deposit date: | 2021-11-02 | | Release date: | 2022-04-06 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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7SP8
 | | Chlorella virus Hyaluronan Synthase bound to UDP-GlcNAc | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | Deposit date: | 2021-11-02 | | Release date: | 2022-04-06 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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7SP9
 | | Chlorella virus Hyaluronan Synthase in the GlcNAc-primed channel-closed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | Deposit date: | 2021-11-02 | | Release date: | 2022-04-06 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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7SP6
 | | Chlorella virus hyaluronan synthase | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | Deposit date: | 2021-11-02 | | Release date: | 2022-04-06 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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7SP7
 | | Chlorella virus hyaluronan synthase inhibited by UDP | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Hyaluronan synthase, ... | | Authors: | Maloney, F.P, Kuklewicz, J, Zimmer, J. | | Deposit date: | 2021-11-02 | | Release date: | 2022-04-06 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure, substrate recognition and initiation of hyaluronan synthase.
Nature, 604, 2022
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5VAQ
 | | Crystal Structure of Beta-Klotho in Complex with FGF21CT | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, Fibroblast growth factor 21, ... | | Authors: | Lee, S, Schlessinger, J. | | Deposit date: | 2017-03-27 | | Release date: | 2018-01-31 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.606 Å) | | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
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5VAN
 | | Crystal Structure of Beta-Klotho | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Lee, S, Schlessinger, J. | | Deposit date: | 2017-03-27 | | Release date: | 2018-01-31 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.202 Å) | | Cite: | Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
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