7TR6
 
 | | Cascade complex from type I-A CRISPR-Cas system | | Descriptor: | Cas11a, Cas5a, Cas7a, ... | | Authors: | Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. | | Deposit date: | 2022-01-28 | | Release date: | 2022-08-10 | | Last modified: | 2022-08-17 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.
Mol.Cell, 82, 2022
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5Y8R
 | | ZsYellow at pH 3.5 | | Descriptor: | GFP-like fluorescent chromoprotein FP538 | | Authors: | Bae, J.E, Kim, I.J, Nam, K.H. | | Deposit date: | 2017-08-21 | | Release date: | 2017-09-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Disruption of the hydrogen bonding network determines the pH-induced non-fluorescent state of the fluorescent protein ZsYellow by protonation of Glu221.
Biochem. Biophys. Res. Commun., 493, 2017
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5Y8Q
 | | ZsYellow at pH 8.0 | | Descriptor: | GFP-like fluorescent chromoprotein FP538 | | Authors: | Bae, J.E, Kim, I.J, Nam, K.H. | | Deposit date: | 2017-08-21 | | Release date: | 2017-09-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Disruption of the hydrogen bonding network determines the pH-induced non-fluorescent state of the fluorescent protein ZsYellow by protonation of Glu221.
Biochem. Biophys. Res. Commun., 493, 2017
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5Y4J
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5Y4I
 | | Crystal structure of glucose isomerase in complex with glycerol in one metal binding mode | | Descriptor: | ACETATE ION, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Bae, J.E, Kim, I.J, Nam, K.H. | | Deposit date: | 2017-08-03 | | Release date: | 2017-09-20 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Crystal structure of glucose isomerase in complex with xylitol inhibitor in one metal binding mode
Biochem. Biophys. Res. Commun., 493, 2017
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5Z6V
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4QQZ
 | | Crystal structure of T. fusca Cas3-AMPPNP | | Descriptor: | CRISPR-associated helicase, Cas3 family, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), ... | | Authors: | Ke, A, Huo, Y, Nam, K.H. | | Deposit date: | 2014-06-30 | | Release date: | 2014-08-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
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4QQY
 | | Crystal structure of T. fusca Cas3-ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CRISPR-associated helicase, Cas3 family, ... | | Authors: | Ke, A, Huo, Y, Nam, K.H. | | Deposit date: | 2014-06-30 | | Release date: | 2014-08-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.12 Å) | | Cite: | Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
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4QQX
 | | Crystal structure of T. fusca Cas3-ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR-associated helicase, Cas3 family, ... | | Authors: | Ke, A, Huo, Y, Nam, K.H. | | Deposit date: | 2014-06-30 | | Release date: | 2014-08-20 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.34 Å) | | Cite: | Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
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4QQW
 | | Crystal structure of T. fusca Cas3 | | Descriptor: | CRISPR-associated helicase, Cas3 family, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), ... | | Authors: | Ke, A, Huo, Y, Nam, K.H. | | Deposit date: | 2014-06-30 | | Release date: | 2014-08-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.664 Å) | | Cite: | Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
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3G9U
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3G9Z
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3G9T
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3H19
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3H1A
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2OHE
 | | Structural and mutational analysis of tRNA-Intron splicing endonuclease from Thermoplasma acidophilum DSM 1728 | | Descriptor: | tRNA-splicing endonuclease | | Authors: | Kim, Y.K, Mizutani, K, Rhee, K.H, Lee, W.H, Park, S.Y, Hwang, K.Y. | | Deposit date: | 2007-01-10 | | Release date: | 2007-11-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and Mutational Analysis of tRNA Intron-Splicing Endonuclease from Thermoplasma acidophilum DSM 1728: Catalytic Mechanism of tRNA Intron-Splicing Endonucleases
J.Bacteriol., 189, 2007
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2OHC
 | | structural and mutational analysis of tRNA-intron splicing endonuclease from Thermoplasma acidophilum DSM1728 | | Descriptor: | tRNA-splicing endonuclease | | Authors: | Kim, Y.K, Mizutani, K, Rhee, K.H, Lee, W.H, Park, S.Y, Hwang, K.Y. | | Deposit date: | 2007-01-10 | | Release date: | 2007-11-27 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural and Mutational Analysis of tRNA Intron-Splicing Endonuclease from Thermoplasma acidophilum DSM 1728: Catalytic Mechanism of tRNA Intron-Splicing Endonucleases
J.Bacteriol., 189, 2007
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3B6R
 | | Crystal structure of Human Brain-type Creatine Kinase | | Descriptor: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, Creatine kinase B-type, ... | | Authors: | Bong, S.M, Moon, J.H, Hwang, K.Y. | | Deposit date: | 2007-10-29 | | Release date: | 2008-11-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex
Febs Lett., 582, 2008
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2NX8
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7MI5
 | | Asymmetrical PAM-Non PAM prespacer bound Cas4/Cas1/Cas2 complex | | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (26-MER), ... | | Authors: | Hu, C.Y, Ke, A.K. | | Deposit date: | 2021-04-16 | | Release date: | 2021-11-17 | | Method: | ELECTRON MICROSCOPY (3.57 Å) | | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Nature, 598, 2021
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7MI4
 | | Symmetrical PAM-PAM prespacer bound Cas4/Cas1/Cas2 complex | | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (35-MER), ... | | Authors: | Hu, C.Y, Ke, A.K. | | Deposit date: | 2021-04-16 | | Release date: | 2021-11-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Nature, 598, 2021
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7MI9
 | | Full integration complex of Cas1/Cas2 from Cas4-containing system | | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (5'-D(P*CP*GP*GP*AP*AP*AP*AP*GP*AP*GP*CP*C)-3'), ... | | Authors: | Hu, C.Y, Ke, A.K. | | Deposit date: | 2021-04-16 | | Release date: | 2021-11-17 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.89 Å) | | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Nature, 598, 2021
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7MIB
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7MID
 | | Sub-complex of Cas4-Cas1-Cas2 bound PAM containing DNA | | Descriptor: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (33-MER), ... | | Authors: | Hu, C.Y, Ke, A.K. | | Deposit date: | 2021-04-16 | | Release date: | 2021-11-17 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas.
Nature, 598, 2021
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5XVN
 | | E. far Cas1-Cas2/prespacer binary complex | | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | | Authors: | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | | Deposit date: | 2017-06-28 | | Release date: | 2017-10-04 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration.
Nature, 550, 2017
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