5K08
| RecA mini intein-Zeise's salt complex | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, RecA mini intein, SULFATE ION, ... | Authors: | Li, Z, Li, H.M. | Deposit date: | 2016-05-17 | Release date: | 2016-09-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Structural insights into protein splicing inhibition by platinum therapeutics as potential anti-microbials To be published
|
|
4AGW
| Discovery of a small molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromet hyl)phenyl}benzamide, GLYCEROL, ... | Authors: | Weisberg, E, Choi, H.G, Seeliger, M, Gray, N, Griffin, J.D. | Deposit date: | 2012-02-01 | Release date: | 2012-02-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of a Small-Molecule Type II Inhibitor of Wild-Type and Gatekeeper Mutants of Bcr-Abl, Pdgfralpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants. Blood, 115, 2010
|
|
7DTK
| |
7DTJ
| |
3C0C
| |
6WQL
| |
6WQJ
| |
3RL7
| Crystal structure of hDLG1-PDZ1 complexed with APC | Descriptor: | 11-mer peptide from Adenomatous polyposis coli protein, Disks large homolog 1 | Authors: | Zhang, Z, Li, H, Wu, G. | Deposit date: | 2011-04-19 | Release date: | 2011-12-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein. Plos One, 6, 2011
|
|
3RES
| |
3KU0
| Structure of GAP31 with adenine at its binding pocket | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENINE, Ribosome-inactivating protein gelonin | Authors: | Kong, X.-P. | Deposit date: | 2009-11-26 | Release date: | 2010-01-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A new activity of anti-HIV and anti-tumor protein GAP31: DNA adenosine glycosidase--structural and modeling insight into its functions. Biochem.Biophys.Res.Commun., 391, 2010
|
|
3SRQ
| S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines | Descriptor: | 1-[3-(2,4-diamino-6-methylquinazolin-7-yl)phenyl]ethanone, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Hilgers, M. | Deposit date: | 2011-07-07 | Release date: | 2011-08-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21, 2011
|
|
4MO7
| Crystal structure of superantigen PfiT | Descriptor: | BETA-MERCAPTOETHANOL, MAGNESIUM ION, Transcriptional regulator I2 | Authors: | Liu, L.H, Chen, H, Li, H.M. | Deposit date: | 2013-09-11 | Release date: | 2014-02-05 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Pfit is a structurally novel Crohn's disease-associated superantigen. Plos Pathog., 9, 2013
|
|
3SRS
| S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines | Descriptor: | 7-(5-bromo-2-ethoxyphenyl)-6-methylquinazoline-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Hilgers, M. | Deposit date: | 2011-07-07 | Release date: | 2011-08-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3TUO
| |
7XP6
| Cryo-EM structure of a class T GPCR in active state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
|
|
7XP4
| Cryo-EM structure of a class T GPCR in apo state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
|
|
7XP5
| Cryo-EM structure of a class T GPCR in ligand-free state | Descriptor: | Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | Deposit date: | 2022-05-03 | Release date: | 2022-10-12 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
|
|
2L3T
| Solution structure of tandem SH2 domain from Spt6 | Descriptor: | Transcription elongation factor SPT6 | Authors: | Liu, J, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2010-09-22 | Release date: | 2011-06-15 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain To be Published
|
|
3KTZ
| Structure of GAP31 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Ribosome-inactivating protein gelonin | Authors: | Kong, X.-P. | Deposit date: | 2009-11-26 | Release date: | 2010-01-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A new activity of anti-HIV and anti-tumor protein GAP31: DNA adenosine glycosidase--structural and modeling insight into its functions. Biochem.Biophys.Res.Commun., 391, 2010
|
|
2K3Q
| |
2K3P
| |
2NB4
| Solution structure of Q388A3 PDZ domain | Descriptor: | Putative uncharacterized protein | Authors: | Mei, S. | Deposit date: | 2016-01-24 | Release date: | 2016-02-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of Q388A3 PDZ domain from Trypanosoma brucei J.Struct.Biol., 194, 2016
|
|
2N7S
| Solution Structure of Leptospiral LigA4 Big Domain | Descriptor: | Ig-like repeat domain protein 1 | Authors: | Mei, S. | Deposit date: | 2015-09-17 | Release date: | 2015-10-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of leptospiral LigA4 Big domain. Biochem. Biophys. Res. Commun., 467, 2015
|
|
8I4V
| Cryo-EM structure of 5-subunit Smc5/6 arm region | Descriptor: | DNA repair protein KRE29, E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, ... | Authors: | Qian, L, Jun, Z, Xiang, Z, Cheng, T, Zhaoning, W, Zhenguo, C, Wang, L. | Deposit date: | 2023-01-21 | Release date: | 2024-06-26 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (5.97 Å) | Cite: | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
|
|
5B7W
| |