6VT4
 
 | | Naegleria gruberi RNA ligase R149A mutant apo | | Descriptor: | RNA Ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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6VTE
 | | Naegleria gruberi RNA Ligase K170M mutant with AMP and Mn | | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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5H8A
 | | Mmi1 YTH domain | | Descriptor: | YTH domain-containing protein mmi1 | | Authors: | Chatterjee, D, Goldgur, Y, Shuman, S. | | Deposit date: | 2015-12-23 | | Release date: | 2016-01-13 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.751 Å) | | Cite: | Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast.
Rna, 22, 2016
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6VT8
 | | Naegleria gruberi RNA ligase E312A mutant with AMP and Mn | | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA Ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.998 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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6VT6
 | | Naegleria gruberi RNA ligase K170A mutant with ATP and Mn | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA Ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.969 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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6VTG
 | | Naegleria gruberi RNA ligase E227A mutant apo | | Descriptor: | RNA ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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6VT9
 | | Naegleria gruberi RNA ligase E227A mutant with ATP and Mn | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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6VT0
 | | Naegleria gruberi RNA ligase K170A mutant apo | | Descriptor: | RNA Ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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6VTB
 | | Naegleria gruberi RNA ligase K326A mutant with ATP and Mn | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, RNA ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.547 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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6VT1
 | | Naegleria gruberi RNA ligase D172A mutant apo | | Descriptor: | ADENOSINE MONOPHOSPHATE, RNA Ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.381 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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5COV
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5COU
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4YKL
 | | Hnt3 in complex with DNA and guanosine | | Descriptor: | Aprataxin-like protein, CHLORIDE ION, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... | | Authors: | Jacewicz, A, Chauleau, M, Shuman, S. | | Deposit date: | 2015-03-04 | | Release date: | 2015-06-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition.
Nucleic Acids Res., 43, 2015
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5E7P
 | | Crystal Structure of MSMEG_0858 (Uniprot A0QQS4), a AAA ATPase. | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein Cdc48, GLYCEROL, ... | | Authors: | Unciulac-Carp, M, Smith, P, Shuman, S. | | Deposit date: | 2015-10-12 | | Release date: | 2016-08-24 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.507 Å) | | Cite: | Crystal Structure and Biochemical Characterization of a Mycobacterium smegmatis AAA-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858).
J.Bacteriol., 198, 2016
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1VS0
 | | Crystal Structure of the Ligase Domain from M. tuberculosis LigD at 2.4A | | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Putative DNA ligase-like protein Rv0938/MT0965, ... | | Authors: | Akey, D, Martins, A, Aniukwu, J, Glickman, M.S, Shuman, S, Berger, J.M, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2006-01-27 | | Release date: | 2006-02-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structure and Nonhomologous End-joining Function of the Ligase Component of Mycobacterium DNA Ligase D.
J.Biol.Chem., 281, 2006
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5COT
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1I9T
 | | CRYSTAL STRUCTURE OF THE OXIDIZED RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME | | Descriptor: | CACODYLATE ION, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... | | Authors: | Changela, A, Ho, C.K, Martins, A, Shuman, S, Mondragon, A. | | Deposit date: | 2001-03-20 | | Release date: | 2001-05-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme.
EMBO J., 20, 2001
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1I9S
 | | CRYSTAL STRUCTURE OF THE RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME | | Descriptor: | CACODYLATE ION, ISOPROPYL ALCOHOL, MAGNESIUM ION, ... | | Authors: | Changela, A, Ho, C.K, Martins, A, Shuman, S, Mondragon, A. | | Deposit date: | 2001-03-20 | | Release date: | 2001-05-23 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme.
EMBO J., 20, 2001
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1FVI
 | | CRYSTAL STRUCTURE OF CHLORELLA VIRUS DNA LIGASE-ADENYLATE | | Descriptor: | ADENOSINE MONOPHOSPHATE, CHLORELLA VIRUS DNA LIGASE-ADENYLATE, SULFATE ION | | Authors: | Odell, M, Sriskanda, V, Shuman, S, Nikolov, D.B. | | Deposit date: | 2000-09-20 | | Release date: | 2000-11-22 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joining.
Mol.Cell, 6, 2000
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1Z3C
 | | Encephalitozooan cuniculi mRNA Cap (Guanine-N7) Methyltransferasein complexed with AzoAdoMet | | Descriptor: | S-5'-AZAMETHIONINE-5'-DEOXYADENOSINE, mRNA CAPPING ENZYME | | Authors: | Hausmann, S, Zhang, S, Fabrega, C, Schneller, S.W, Lima, C.D, Shuman, S. | | Deposit date: | 2005-03-11 | | Release date: | 2005-03-22 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis.
J.Biol.Chem., 280, 2005
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1N82
 | | The high-resolution crystal structure of IXT6, a thermophilic, intracellular xylanase from G. stearothermophilus | | Descriptor: | GLYCEROL, SODIUM ION, intra-cellular xylanase | | Authors: | Solomon, V, Teplitsky, A, Golan, G, Gilboa, R, Reiland, V, Shulami, S, Moryles, S, Zolotnitsky, G, Shoham, Y, Shoham, G. | | Deposit date: | 2002-11-19 | | Release date: | 2003-11-25 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | The high-resolution crystal structure of IXT6,
a thermophilic, intracellular xylanase from G. stearothermophilus
To be Published
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7KW9
 | | NMR Structure of a tRNA 2'-phosphotransferase from Runella slithyformis in complex with NAD+ | | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, tRNA 2'-phosphotransferase | | Authors: | Alphonse, S, Dantuluri, S, Banerjee, A, Shuman, S, Ghose, R. | | Deposit date: | 2020-11-30 | | Release date: | 2021-10-13 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity.
Nucleic Acids Res., 49, 2021
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7KW8
 | | NMR Structure of a tRNA 2'-phosphotransferase from Runella slithyformis | | Descriptor: | tRNA 2'-phosphotransferase | | Authors: | Alphonse, S, Dantuluri, S, Banerjee, A, Shuman, S, Ghose, R. | | Deposit date: | 2020-11-30 | | Release date: | 2021-10-13 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | NMR solution structures of Runella slithyformis RNA 2'-phosphotransferase Tpt1 provide insights into NAD+ binding and specificity.
Nucleic Acids Res., 49, 2021
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1RI5
 | | Structure and mechanism of mRNA cap (guanine N-7) methyltransferase | | Descriptor: | mRNA CAPPING ENZYME | | Authors: | Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2003-11-16 | | Release date: | 2004-02-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase
Mol.Cell, 13, 2004
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1RI4
 | | Structure and mechanism of mRNA cap (guanine N-7) methyltransferase | | Descriptor: | S-ADENOSYLMETHIONINE, mRNA CAPPING ENZYME | | Authors: | Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D. | | Deposit date: | 2003-11-16 | | Release date: | 2004-02-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase
Mol.Cell, 13, 2004
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