5O3S
 
 | | Carbon regulatory PII-like protein SbtB from Synechocystis sp. 6803 in Apo state, hexagonal crystal form | | Descriptor: | Membrane-associated protein slr1513 | | Authors: | Selim, K.A, Albrecht, R, Forchhammer, K, Hartmann, M.D. | | Deposit date: | 2017-05-24 | | Release date: | 2018-05-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | PII-like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5OH8
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Rolipram | | Descriptor: | Cereblon isoform 4, ROLIPRAM, ZINC ION | | Authors: | Boichenko, I, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D. | | Deposit date: | 2017-07-14 | | Release date: | 2018-10-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Chemical Ligand Space of Cereblon.
Acs Omega, 3, 2018
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6R5Y
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6R60
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6R5Z
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6R5X
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5OVT
 | | Thiobacillus denitrificans BPH in complex with Epoxomicin | | Descriptor: | BPH, Epoxomicin, PHOSPHATE ION | | Authors: | Fuchs, A.C.D, Albrecht, R, Martin, J, Hartmann, M.D. | | Deposit date: | 2017-08-29 | | Release date: | 2017-12-06 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties.
J. Biol. Chem., 293, 2018
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5O3Q
 | | Carbon regulatory PII-like protein SbtB from Synechocystis sp. 6803 in complex with cyclic AMP (cAMP) | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, BICARBONATE ION, Membrane-associated protein slr1513 | | Authors: | Selim, K.A, Albrecht, R, Forchhammer, K, Hartmann, M.D. | | Deposit date: | 2017-05-24 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | PII-like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5OVU
 | | Cupriavidus metallidurans BPH | | Descriptor: | BETA-PROTEOBACTERIA PROTEASOME HOMOLOGUE, MALONATE ION | | Authors: | Fuchs, A.C.D, Albrecht, R, Martin, J, Hartmann, M.D. | | Deposit date: | 2017-08-29 | | Release date: | 2017-12-06 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties.
J. Biol. Chem., 293, 2018
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5O3P
 | | Carbon regulatory PII-like protein SbtB from Synechocystis sp. 6803 in Apo state, trigonal crystal form | | Descriptor: | DI(HYDROXYETHYL)ETHER, Membrane-associated protein slr1513, PENTAETHYLENE GLYCOL | | Authors: | Selim, K.A, Albrecht, R, Forchhammer, K, Hartmann, M.D. | | Deposit date: | 2017-05-24 | | Release date: | 2018-05-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | PII-like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7PS9
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Iberdomide (CC-220) | | Descriptor: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, Cereblon isoform 4, ZINC ION | | Authors: | Heim, C, Hartmann, M.D. | | Deposit date: | 2021-09-22 | | Release date: | 2022-03-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system.
Acta Crystallogr D Struct Biol, 78, 2022
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5LOY
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5LOX
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5FZR
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5FZS
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5FZQ
 | | Designed TPR Protein M4N | | Descriptor: | DESIGNED TPR PROTEIN, SULFATE ION | | Authors: | Albrecht, R, Zhu, H, Hartmann, M.D. | | Deposit date: | 2016-03-15 | | Release date: | 2016-10-12 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.148 Å) | | Cite: | Origin of a folded repeat protein from an intrinsically disordered ancestor.
Elife, 5, 2016
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7OBJ
 | | Carbon regulatory PII-like protein SbtB from Synechocystis sp. 6803 in complex with cyclic di-AMP (c-di-AMP) | | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Membrane-associated protein slr1513 | | Authors: | Selim, K.A, Albrecht, R, Hartmann, M.D. | | Deposit date: | 2021-04-22 | | Release date: | 2022-02-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB.
Sci Adv, 7, 2021
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7O4X
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7PJK
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with a benzotriazole analog of thalidomide | | Descriptor: | (3S)-3-(benzotriazol-2-yl)piperidine-2,6-dione, Cereblon isoform 4, ZINC ION | | Authors: | Heim, C, Hartmann, M.D, Maiwald, S. | | Deposit date: | 2021-08-24 | | Release date: | 2022-03-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Replacing the phthalimide core in thalidomide with benzotriazole.
J Enzyme Inhib Med Chem, 37, 2022
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7PSO
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5A1Q
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6R0V
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6R0U
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 5a and hydrolysis product | | Descriptor: | 3-azanyl-2-[[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamoyl]benzoic acid, 4-azanyl-2-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]isoindole-1,3-dione, CHLORIDE ION, ... | | Authors: | Heim, C, Hartmann, M.D. | | Deposit date: | 2019-03-13 | | Release date: | 2019-08-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives.
J.Med.Chem., 62, 2019
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6R0S
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with compound 4a and hydrolysis product | | Descriptor: | 2-[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-4-nitro-isoindole-1,3-dione, 2-[[(3~{S})-2,5-bis(oxidanylidene)pyrrolidin-3-yl]carbamoyl]-6-nitro-benzoic acid, CEREBLON ISOFORM 4, ... | | Authors: | Heim, C, Hartmann, M.D. | | Deposit date: | 2019-03-13 | | Release date: | 2019-08-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives.
J.Med.Chem., 62, 2019
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6R0Q
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