8TC9
 
 | | Human asparaginyl-tRNA synthetase bound to OSM-S-106 | | Descriptor: | Asparagine--tRNA ligase, cytoplasmic, GLYCEROL, ... | | Authors: | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | | Deposit date: | 2023-06-30 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Nat Commun, 15, 2024
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8TC7
 | | Human asparaginyl-tRNA synthetase, apo form | | Descriptor: | Asparagine--tRNA ligase, cytoplasmic, CHLORIDE ION, ... | | Authors: | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | | Deposit date: | 2023-06-30 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Nat Commun, 15, 2024
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8JMT
 | | Structure of the adhesion GPCR ADGRL3 in the apo state | | Descriptor: | Adhesion G protein-coupled receptor L3,Soluble cytochrome b562 | | Authors: | Tao, Y, Guo, Q, He, B, Zhong, Y. | | Deposit date: | 2023-06-05 | | Release date: | 2023-09-06 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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7VH0
 | | MT2-remalteon-Gi complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Melatonin receptor type 1B, ... | | Authors: | Wang, Q.G, Lu, Q.Y. | | Deposit date: | 2021-09-20 | | Release date: | 2022-03-02 | | Last modified: | 2022-09-14 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
Nat Commun, 13, 2022
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7VGZ
 | | MT1-remalteon-Gi complex | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, Q.G, Lu, Q.Y. | | Deposit date: | 2021-09-20 | | Release date: | 2022-03-02 | | Last modified: | 2022-09-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
Nat Commun, 13, 2022
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7VGY
 | | Melatonin receptor1-2-Iodomelatonin-Gicomplex | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wang, Q.G, Lu, Q.Y. | | Deposit date: | 2021-09-20 | | Release date: | 2022-03-02 | | Last modified: | 2022-09-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
Nat Commun, 13, 2022
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8JJ8
 | | Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with a partial agonist | | Descriptor: | Beta-2 adrenergic receptor,Soluble cytochrome b562, ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide | | Authors: | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | Deposit date: | 2023-05-29 | | Release date: | 2023-09-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8JJL
 | | cryo-EM structure of the beta2-AR-mBRIL/1b3 Fab/Glue complex with a full agonist | | Descriptor: | Beta-2 adrenergic receptor,Soluble cytochrome b562, Olodaterol | | Authors: | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | Deposit date: | 2023-05-30 | | Release date: | 2023-09-06 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8J7E
 | | Crystal structure of BRIL in complex with 1b3 Fab | | Descriptor: | Antibody 1b3 Fab Heavy chain, Antibody 1b3 Fab Light chain, Soluble cytochrome b562 | | Authors: | Zhong, Y.X, Guo, Q, Tao, Y.Y. | | Deposit date: | 2023-04-27 | | Release date: | 2023-09-06 | | Last modified: | 2024-01-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8JJO
 | | Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with an antagonist | | Descriptor: | (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, Beta-2 adrenergic receptor,Beta-2 adrenergic receptor,Soluble cytochrome b562 | | Authors: | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | Deposit date: | 2023-05-31 | | Release date: | 2023-09-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8HGO
 | | The EGF-bound EGFR/HER2 ectodomain complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor, ... | | Authors: | Zhang, Z, Bai, X. | | Deposit date: | 2022-11-15 | | Release date: | 2023-02-08 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
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8HGP
 | | The EREG-bound EGFR/HER2 ectodomain complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... | | Authors: | Zhang, Z, Bai, X. | | Deposit date: | 2022-11-15 | | Release date: | 2023-02-08 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (4.53 Å) | | Cite: | Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
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8HGS
 | | The EGF-bound EGFR ectodomain homodimer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Pro-epidermal growth factor, ... | | Authors: | Zhang, Z, Bai, X. | | Deposit date: | 2022-11-15 | | Release date: | 2023-02-15 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | Structure and dynamics of the EGFR/HER2 heterodimer.
Cell Discov, 9, 2023
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8HR1
 | | Cryo-EM structure of SSX1 bound to the unmodified nucleosome at a resolution of 3.02 angstrom | | Descriptor: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | Authors: | Zebin, T, Ai, H.S, Ziyu, X, Man, P, Liu, L. | | Deposit date: | 2022-12-14 | | Release date: | 2023-09-13 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes.
Nat.Struct.Mol.Biol., 31, 2024
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8HQY
 | | Cryo-EM structure of SSX1 bound to the H2AK119Ub nucleosome at a resolution of 3.05 angstrom | | Descriptor: | DNA (136-MER), DNA (137-MER), Histone H2A type 1-B/E, ... | | Authors: | Zebin, T, Ai, H.S, Ziyu, X, GuoChao, C, Man, P, Liu, L. | | Deposit date: | 2022-12-14 | | Release date: | 2023-09-27 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes.
Nat.Struct.Mol.Biol., 31, 2024
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8IYA
 | | Complex of SETDB1-derived peptide bound to UBE2E1 | | Descriptor: | Histone-lysine N-methyltransferase SETDB1, SULFATE ION, Ubiquitin-conjugating enzyme E2 E1 | | Authors: | Du, Y.X, Liu, L. | | Deposit date: | 2023-04-04 | | Release date: | 2024-01-03 | | Last modified: | 2024-07-17 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1.
Nat Commun, 15, 2024
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6WEB
 | | Multi-Hit SFX using MHz XFEL sources | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | Authors: | Holmes, S, Darmanin, C, Abbey, B. | | Deposit date: | 2020-04-01 | | Release date: | 2021-10-13 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers.
Nat Commun, 13, 2022
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6WEC
 | | Multi-Hit SFX using MHz XFEL sources | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | Authors: | Holmes, S, Darmanin, C, Abbey, B. | | Deposit date: | 2020-04-01 | | Release date: | 2021-10-13 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers.
Nat Commun, 13, 2022
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8JTL
 | | Structure of OY phytoplasma SAP05 binding with AtRpn10 | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 4 homolog, Sequence-variable mosaic (SVM) signal sequence domain-containing protein | | Authors: | Du, Y.X, Zhang, L.Y, Zheng, Q.Y. | | Deposit date: | 2023-06-22 | | Release date: | 2023-07-12 | | Last modified: | 2024-07-17 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structure basis for recognition of plant Rpn10 by phytoplasma SAP05 in ubiquitin-independent protein degradation.
Iscience, 27, 2024
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8JTK
 | | Structure of AYWB phytoplasma SAP05 recognizing AtRpn10 | | Descriptor: | 26S proteasome non-ATPase regulatory subunit 4 homolog, Sequence-variable mosaic (SVM) signal sequence domain-containing protein | | Authors: | Du, Y.X, Zhang, L.Y, Zheng, Q.Y. | | Deposit date: | 2023-06-22 | | Release date: | 2023-07-19 | | Last modified: | 2024-07-17 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Structure basis for recognition of plant Rpn10 by phytoplasma SAP05 in ubiquitin-independent protein degradation.
Iscience, 27, 2024
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6IYF
 | | Structure of pSTING complex | | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, SULFATE ION, Stimulator of interferon genes protein | | Authors: | Yuan, Z.L, Shang, G.J, Cong, X.Y, Gu, L.C. | | Deposit date: | 2018-12-15 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.764 Å) | | Cite: | Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins.
J.Biol.Chem., 294, 2019
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8IS5
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8IS4
 | | Structure of an Isocytosine specific deaminase Vcz in complexed with 5-FU | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-FLUOROURACIL, GLYCEROL, ... | | Authors: | Guo, W.T, Li, X.J, Wu, B.X. | | Deposit date: | 2023-03-20 | | Release date: | 2023-08-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy.
Iscience, 26, 2023
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5GJK
 | | Crystal Structure of BAF47 and BAF155 Complex | | Descriptor: | GLYCEROL, PHOSPHATE ION, SWI/SNF complex subunit SMARCC1, ... | | Authors: | Yan, L, Qian, C. | | Deposit date: | 2016-06-30 | | Release date: | 2017-06-07 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.052 Å) | | Cite: | Structural Insights into BAF47 and BAF155 Complex Formation.
J. Mol. Biol., 429, 2017
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9BLN
 | | The structure of human Pdcd4 bound to the 40S-eIF4A-eIF3-eIF1 complex | | Descriptor: | 40S ribosomal protein S14, ACETIC ACID, Eukaryotic initiation factor 4A-I, ... | | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Yifei, D, Albacete-Albacete, L, Ramakrishnan, V, S Fraser, C. | | Deposit date: | 2024-04-30 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit.
Nat Commun, 15, 2024
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