3C5C
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![BU of 3c5c by Molmil](/molmil-images/mine/3c5c) | Crystal structure of human Ras-like, family 12 protein in complex with GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-like protein 12, ... | Authors: | Shen, L, Tong, Y, Tempel, W, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-31 | Release date: | 2008-02-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of human Ras-like, family 12 protein in complex with GDP. To be Published
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3BLV
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![BU of 3blv by Molmil](/molmil-images/mine/3blv) | Yeast Isocitrate Dehydrogenase with Citrate Bound in the Regulatory Subunits | Descriptor: | CITRATE ANION, Isocitrate dehydrogenase [NAD] subunit 1, Isocitrate dehydrogenase [NAD] subunit 2 | Authors: | Taylor, A.B, Hu, G, Hart, P.J, McAlister-Henn, L. | Deposit date: | 2007-12-11 | Release date: | 2008-02-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Allosteric Motions in Structures of Yeast NAD+-specific Isocitrate Dehydrogenase. J.Biol.Chem., 283, 2008
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3C6R
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![BU of 3c6r by Molmil](/molmil-images/mine/3c6r) | Low pH Immature Dengue Virus | Descriptor: | Envelope protein, Peptide pr | Authors: | Yu, I, Zhang, W, Holdway, H.A, Li, L, Kostyuchenko, V.A, Chipman, P.R, Kuhn, R.J, Rossmann, M.G, Chen, J. | Deposit date: | 2008-02-05 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (25 Å) | Cite: | Structure of the immature dengue virus at low pH primes proteolytic maturation Science, 319, 2008
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2WP0
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![BU of 2wp0 by Molmil](/molmil-images/mine/2wp0) | Crystal structure of a HobA-DnaA (domain I-II) complex from Helicobacter pylori. | Descriptor: | ACETATE ION, CHLORIDE ION, CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA, ... | Authors: | Natrajan, G, Noirot-Gros, M.-F, Zawilak-Pawlik, A, Kapp, U, Terradot, L. | Deposit date: | 2009-07-31 | Release date: | 2009-11-17 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | The Structure of a Dnaa/Hoba Complex from Helicobacter Pylori Provides Insight Into Regulation of DNA Replication in Bacteria. Proc.Natl.Acad.Sci.USA, 106, 2009
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3I33
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![BU of 3i33 by Molmil](/molmil-images/mine/3i33) | Crystal structure of the human 70kDa heat shock protein 2 (Hsp70-2) ATPase domain in complex with ADP and inorganic phosphate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock-related 70 kDa protein 2, ... | Authors: | Wisniewska, M, Karlberg, T, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Kotzsch, A, Nielsen, T.K, Nordlund, P, Nyman, T, Moche, M, Persson, C, Roos, A.K, Sagemark, J, Schutz, P, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van den Berg, S, Weigelt, J, Welin, M, Schueler, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-30 | Release date: | 2009-07-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78 Plos One, 5, 2010
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2WRV
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![BU of 2wrv by Molmil](/molmil-images/mine/2wrv) | Semi-synthetic highly active analogue of human insulin NMeHisB26-DTI- NH2 | Descriptor: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | Deposit date: | 2009-09-02 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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3BL7
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![BU of 3bl7 by Molmil](/molmil-images/mine/3bl7) | Synthetic Gene Encoded DcpS bound to inhibitor DG156844 | Descriptor: | 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS | Authors: | Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | Deposit date: | 2007-12-10 | Release date: | 2008-10-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
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2WOX
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![BU of 2wox by Molmil](/molmil-images/mine/2wox) | Betaine aldehyde dehydrogenase from Pseudomonas aeruginosa with NAD(P) H-catalytic thiol adduct. | Descriptor: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, BETA-MERCAPTOETHANOL, BETAINE ALDEHYDE DEHYDROGENASE, ... | Authors: | Gonzalez-Segura, L, Rudino-Pinera, E, Diaz-Sanchez, A.G, Munoz-Clares, R.A. | Deposit date: | 2009-07-30 | Release date: | 2010-08-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Novel NADPH-cysteine covalent adduct found in the active site of an aldehyde dehydrogenase. Biochem. J., 439, 2011
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2WRW
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![BU of 2wrw by Molmil](/molmil-images/mine/2wrw) | Semi-synthetic highly active analogue of human insulin D-ProB26-DTI- NH2 | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | Deposit date: | 2009-09-02 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WS6
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![BU of 2ws6 by Molmil](/molmil-images/mine/2ws6) | Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form | Descriptor: | CHLORIDE ION, GLYCEROL, INSULIN A CHAIN, ... | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | Deposit date: | 2009-09-03 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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3BOH
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![BU of 3boh by Molmil](/molmil-images/mine/3boh) | Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 1 with acetate (CDCA1-R1) | Descriptor: | ACETATE ION, CADMIUM ION, Cadmium-specific carbonic anhydrase | Authors: | Xu, Y, Feng, L, Jeffrey, P.D, Shi, Y, Morel, F.M.M. | Deposit date: | 2007-12-17 | Release date: | 2008-01-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature, 452, 2008
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3BWA
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![BU of 3bwa by Molmil](/molmil-images/mine/3bwa) | Crystal Structure of HLA B*3508 in complex with a HCMV 8-mer peptide from the pp65 protein | Descriptor: | Beta-2-microglobulin, FPT peptide from 65 kDa lower matrix phosphoprotein, HLA class I histocompatibility antigen, ... | Authors: | Wynn, K.K, Marland, Z, Cooper, L, Silins, S.L, Gras, S, Archbold, J.K, Tynan, F.E, Miles, J.J, McCluskey, J, Burrows, S.R, Rossjohn, J, Khanna, R. | Deposit date: | 2008-01-08 | Release date: | 2008-04-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection Blood, 111, 2008
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3BX8
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![BU of 3bx8 by Molmil](/molmil-images/mine/3bx8) | Engineered Human Lipocalin 2 (LCN2), apo-form | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ENGINEERED HUMAN LIPOCALIN 2, PENTAETHYLENE GLYCOL | Authors: | Schonfeld, D.L, Chatwell, L, Skerra, A. | Deposit date: | 2008-01-11 | Release date: | 2009-01-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | High affinity molecular recognition and functional blockade of CTLA-4 by an engineered human lipocalin To be Published
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2WUS
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![BU of 2wus by Molmil](/molmil-images/mine/2wus) | Bacterial actin MreB assembles in complex with cell shape protein RodZ | Descriptor: | PUTATIVE UNCHARACTERIZED PROTEIN, ROD SHAPE-DETERMINING PROTEIN MREB | Authors: | van den Ent, F, Johnson, C.M, Persons, L, deBoer, P, Lowe, J. | Deposit date: | 2009-10-08 | Release date: | 2010-06-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Bacterial Actin Mreb Assembles in Complex with Cell Shape Protein Rodz. Embo J., 29, 2010
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2X7W
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![BU of 2x7w by Molmil](/molmil-images/mine/2x7w) | Crystal structure of Thermotoga maritima endonuclease IV in the presence of cadmium and zinc | Descriptor: | BICINE, CADMIUM ION, PROBABLE ENDONUCLEASE 4, ... | Authors: | Tomanicek, S.J, Hughes, R.C, Ng, J.D, Coates, L. | Deposit date: | 2010-03-03 | Release date: | 2010-09-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structure of the Endonuclease Iv Homologue from Thermotoga Maritima in the Presence of Active-Site Divalent Metal Ions Acta Crystallogr.,Sect.F, 66, 2010
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2X89
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![BU of 2x89 by Molmil](/molmil-images/mine/2x89) | Structure of the Beta2_microglobulin involved in amyloidogenesis | Descriptor: | ANTIBODY, BETA-2-MICROGLOBULIN | Authors: | Domanska, K, Srinivasan, V, Vanderhaegen, S, Pardon, E, Marquez, J.A, Bellotti, V, Wyns, L, Steyaert, J. | Deposit date: | 2010-03-07 | Release date: | 2011-01-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Atomic Structure of a Nanobody-Trapped Domain-Swapped Dimer of an Amyloidogenic {Beta}2-Microglobulin Variant. Proc.Natl.Acad.Sci.USA, 108, 2011
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3BVH
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![BU of 3bvh by Molmil](/molmil-images/mine/3bvh) | Crystal Structure of Recombinant gammaD364A Fibrinogen Fragment D with the Peptide Ligand Gly-Pro-Arg-Pro-Amide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-mer peptide GPRP, CALCIUM ION, ... | Authors: | Bowley, S.R, Merenbloom, B.K, Betts, L, Okumura, N, Heroux, A, Gorkun, O.V, Lord, S.T. | Deposit date: | 2008-01-07 | Release date: | 2008-09-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Polymerization-defective fibrinogen variant gammaD364A binds knob "A" peptide mimic. Biochemistry, 47, 2008
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3C2I
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![BU of 3c2i by Molmil](/molmil-images/mine/3c2i) | The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF | Descriptor: | DNA (5'-D(*DAP*DTP*DAP*DGP*DAP*DAP*DGP*DAP*DAP*DTP*DTP*DCP*(5CM)P*DGP*DTP*DTP*DCP*DCP*DAP*DG)-3'), DNA (5'-D(*DTP*DCP*DTP*DGP*DGP*DAP*DAP*(5CM)P*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DTP*DTP*DCP*DTP*DA)-3'), Methyl-CpG-binding protein 2 | Authors: | Ho, K.L, McNae, I.W, Schmiedeberg, L, Klose, R.J, Bird, A.P, Walkinshaw, M.D. | Deposit date: | 2008-01-25 | Release date: | 2008-05-13 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | MeCP2 binding to DNA depends upon hydration at methyl-CpG Mol.Cell, 29, 2008
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3BWH
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![BU of 3bwh by Molmil](/molmil-images/mine/3bwh) | Atomic resolution structure of cucurmosin, a novel type 1 RIP from the sarcocarp of Cucurbita moschata | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, beta-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, L. | Deposit date: | 2008-01-09 | Release date: | 2008-10-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. J.Struct.Biol., 164, 2008
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2X1R
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![BU of 2x1r by Molmil](/molmil-images/mine/2x1r) | Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase | Descriptor: | 3-(PROPYLSULFONYL)PROPANOIC ACID, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE, ... | Authors: | Salin, M, Kapetaniou, E.G, Vaismaa, M, Lajunen, M, Casteleijn, M.G, Neubauer, P, Salmon, L, Wierenga, R. | Deposit date: | 2010-01-04 | Release date: | 2010-01-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Crystallographic Binding Studies with an Engineered Monomeric Variant of Triosephosphate Isomerase Acta Crystallogr.,Sect.D, 66, 2010
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2XM7
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![BU of 2xm7 by Molmil](/molmil-images/mine/2xm7) | Structural and Mechanistic Analysis of the Magnesium-Independent Aromatic Prenyltransferase CloQ from the Clorobiocin Biosynthetic Pathway | Descriptor: | (2R)-2-HYDROXY-3-(4-HYDROXYPHENYL)PROPANOIC ACID, 1,2-ETHANEDIOL, CLOQ, ... | Authors: | Metzger, U, Keller, S, Stevenson, C.E.M, Heide, L, Lawson, D.M. | Deposit date: | 2010-07-25 | Release date: | 2010-10-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Structure and Mechanism of the Magnesium-Independent Aromatic Prenyltransferase Cloq from the Clorobiocin Biosynthetic Pathway. J.Mol.Biol., 404, 2010
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2XM8
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![BU of 2xm8 by Molmil](/molmil-images/mine/2xm8) | Co-crystal structure of a small molecule inhibitor bound to the kinase domain of Chk2 | Descriptor: | 2-{4-[(3S)-PYRROLIDIN-3-YLAMINO]QUINAZOLIN-2-YL}PHENOL, SERINE/THREONINE-PROTEIN KINASE CHK2 | Authors: | Caldwell, J.J, Welsh, E.J, Matijssen, C, Anderson, V.E, Antoni, L, Boxall, K, Urban, F, Hayes, A, Raynaud, F.I, Rigoreau, L.J, Raynham, T, Aherne, G.W, Pearl, L.H, Oliver, A.W, Garrett, M.D, Collins, I. | Deposit date: | 2010-07-26 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure-Based Design of Potent and Selective 2-(Quinazolin-2-Yl)Phenol Inhibitors of Checkpoint Kinase 2. J.Med.Chem., 54, 2011
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2XMY
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![BU of 2xmy by Molmil](/molmil-images/mine/2xmy) | Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents | Descriptor: | 4-[4-(3,4-DIMETHYL-2-OXO-2,3-DIHYDRO-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-N-(2-METHOXY-ETHYL)-BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 | Authors: | Wang, S, Griffiths, G, Midgley, C.A, Barnett, A.L, Cooper, M, Grabarek, J, Ingram, L, Jackson, W, Kontopidis, G, McClue, S.J, McInnes, C, McLachlan, J, Meades, C, Mezna, M, Stuart, I, Thomas, M.P, Zheleva, D.I, Lane, D.P, Jackson, R.C, Glover, D.M, Blake, D.G, Fischer, P.M. | Deposit date: | 2010-07-29 | Release date: | 2010-11-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery and Characterisation of 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents Chem.Biol., 17, 2010
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2XO3
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![BU of 2xo3 by Molmil](/molmil-images/mine/2xo3) | |
2XP3
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![BU of 2xp3 by Molmil](/molmil-images/mine/2xp3) | DISCOVERY OF CELL-ACTIVE PHENYL-IMIDAZOLE PIN1 INHIBITORS BY STRUCTURE-GUIDED FRAGMENT EVOLUTION | Descriptor: | 5-(2-METHOXYPHENYL)-2-FUROIC ACID, DODECAETHYLENE GLYCOL, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 | Authors: | Potter, A, Oldfield, V, Nunns, C, Fromont, C, Ray, S, Northfield, C.J, Bryant, C.J, Scrace, S.F, Robinson, D, Matossova, N, Baker, L, Dokurno, P, Surgenor, A.E, Davis, B.E, Richardson, C.M, Murray, J.B, Moore, J.D. | Deposit date: | 2010-08-25 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of Cell-Active Phenyl-Imidazole Pin1 Inhibitors by Structure-Guided Fragment Evolution. Bioorg.Med.Chem.Lett., 20, 2010
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