8W3Q
 
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8W3E
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR1 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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8W3O
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR3-GDQ | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, prefusion-stabilized RSV F protein UFCR3-GDQ | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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8W3G
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR1(1TD0) | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Prefusion-stabilized RSV F protein UFCR1(1TD0) | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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8W3H
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR1-iSS | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Prefusion-stabilized RSV F protein UFCR1-iSS | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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8W3K
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR2-iSS-NQ | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Prefusion-stabilized RSV F protein UFCR2-iSS-NQ | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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5WK4
 | | Crystal structure of an anti-idiotype VLR | | Descriptor: | MAGNESIUM ION, Variable lymphocyte receptor 39 | | Authors: | Collins, B.C, Nakahara, H, Cooper, M.D, Herrin, B.R, Wilson, I.A. | | Deposit date: | 2017-07-24 | | Release date: | 2017-12-13 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.498 Å) | | Cite: | Crystal structure of an anti-idiotype variable lymphocyte receptor.
Acta Crystallogr F Struct Biol Commun, 73, 2017
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8W3I
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR1-L2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, Prefusion-stabilized RSV F protein UFCR1-L2 | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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8W3L
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR2-iSS-P2-NQ | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, prefusion-stabilized RSV F protein UFCR2-iSS-P2-NQ | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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8W3N
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, prefusion-stabilized RSV F protein UFCR3 | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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8W3P
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR3-D(1TD0) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, prefusion-stabilized RSV F protein UFCR3-D(1TD0) | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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6BZV
 | | Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody 19B3 | | Descriptor: | 19B3 GL Heavy Chain, 19B3 GL Light Chain, E2 AS412 peptide | | Authors: | Tzarum, N, Aleman, F, Wilson, I.A, Law, M. | | Deposit date: | 2017-12-26 | | Release date: | 2018-06-20 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.654 Å) | | Cite: | Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BKP
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7KN6
 | | Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobody VHH V and antibody Fab CC12.3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 Fab heavy chain, CC12.3 Fab light chain, ... | | Authors: | Liu, H, Yuan, M, Zhu, X, Wu, N.C, Wilson, I.A. | | Deposit date: | 2020-11-04 | | Release date: | 2021-01-20 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Science, 371, 2021
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6BXE
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7KN7
 | | Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobody VHH W and antibody Fab CC12.3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.3 Fab heavy chain, CC12.3 Fab light chain, ... | | Authors: | Liu, H, Yuan, M, Zhu, X, Wu, N.C, Wilson, I.A. | | Deposit date: | 2020-11-04 | | Release date: | 2021-01-20 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Science, 371, 2021
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6BZU
 | | Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 19B3 | | Descriptor: | 19B3 Heavy Chain, 19B3 Light Chain, E2 AS412 peptide | | Authors: | Tzarum, N, Aleman, F, Kong, L, Wilson, I.A, Law, M. | | Deposit date: | 2017-12-26 | | Release date: | 2018-06-20 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BZY
 | | Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the 22D11 broadly neutralizing antibody | | Descriptor: | 22D11 Heavy Chain, 22D11 Light Chain, E2 AS412 peptide | | Authors: | Tzarum, N, Aleman, F, Wilson, I.A, Law, M. | | Deposit date: | 2017-12-26 | | Release date: | 2018-06-20 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BXC
 | | Crystal structure of N-terminal fragment of Zebrafish Toll-Like Receptor 5 (TLR5) with Lamprey Variable Lymphocyte Receptor 9 (VLR9) bound | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Gunn, R.J, Wilson, I.A, Cooper, M.D, Herrin, B.R. | | Deposit date: | 2017-12-18 | | Release date: | 2018-05-09 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | VLR Recognition of TLR5 Expands the Molecular Characterization of Protein Antigen Binding by Non-Ig-based Antibodies.
J. Mol. Biol., 430, 2018
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6E3H
 | | Crystal structure of S9-3-37 bound to H5 influenza hemagglutinin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, ... | | Authors: | Wu, N.C, Wilson, I.A. | | Deposit date: | 2018-07-14 | | Release date: | 2018-09-26 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The D3-9 gene segment encodes for recurring and adaptable binding motifs in broadly neutralizing antibodies to influenza virus
Cell Host Microbe, 2018
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5VLI
 | | Computationally designed inhibitor peptide HB1.6928.2.3 in complex with influenza hemagglutinin (A/PuertoRico/8/1934) | | Descriptor: | 2,5,8,11-TETRAOXATRIDECANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Bernard, S.M, Wilson, I.A. | | Deposit date: | 2017-04-25 | | Release date: | 2017-09-27 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.799 Å) | | Cite: | Massively parallel de novo protein design for targeted therapeutics.
Nature, 550, 2017
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5VJL
 | | Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTc | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2, ... | | Authors: | Zhu, X, Wilson, I.A. | | Deposit date: | 2017-04-19 | | Release date: | 2017-05-24 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.597 Å) | | Cite: | Three mutations switch H7N9 influenza to human-type receptor specificity.
PLoS Pathog., 13, 2017
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6CE0
 | | Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ... | | Authors: | Kumar, S, Sarkar, A, Wilson, I.A. | | Deposit date: | 2018-02-09 | | Release date: | 2018-12-05 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (4.602 Å) | | Cite: | HIV-1 vaccine design through minimizing envelope metastability.
Sci Adv, 4, 2018
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6CJK
 | | Anti HIV Fab 10A | | Descriptor: | ACETATE ION, GLYCEROL, Immunoglobulin Fab heavy chain, ... | | Authors: | Hangartner, L, Ward, A.B, Wilson, I.A, Oyen, D. | | Deposit date: | 2018-02-26 | | Release date: | 2018-08-15 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.795 Å) | | Cite: | Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.
Immunity, 49, 2018
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7K75
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