6B9Y
| Trastuzumab Fab v3 in complex with 5-phenyl meditope variant | Descriptor: | Immunoglobulin G binding protein A, Protein L, Trastuzumab Fab heavy chain, ... | Authors: | Bzymek, K.P, King, J.D, Williams, J.C. | Deposit date: | 2017-10-11 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Template-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag. Bioconjug. Chem., 29, 2018
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6AZK
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3DVT
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3DVH
| LC8 Point mutant K36P | Descriptor: | Dynein light chain 1, cytoplasmic | Authors: | Lightcap, C.M, Williams, J.C. | Deposit date: | 2008-07-18 | Release date: | 2009-01-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Biochemical and structural characterization of the Pak1-LC8 interaction. J.Biol.Chem., 283, 2008
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3DVP
| Pak1 peptide bound LC8 | Descriptor: | Dynein light chain 1, cytoplasmic, P21 activated Kinase peptide | Authors: | Lightcap, C.M, Williams, J.C. | Deposit date: | 2008-07-18 | Release date: | 2009-01-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Biochemical and structural characterization of the Pak1-LC8 interaction. J.Biol.Chem., 283, 2008
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5EUK
| Cetuximab Fab in complex with F3H meditope variant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab heavy chain, Cetuximab Fab light chain, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2015-11-18 | Release date: | 2016-10-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5ESQ
| Cetuximab Fab in complex with cyclic beta-alanine-linked meditope | Descriptor: | Cetuximab Fab heavy chain, Cetuximab Fab light chain, Cyclic beta-alanine-linked meditope, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2015-11-16 | Release date: | 2016-06-15 | Last modified: | 2017-12-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5ETU
| Cetuximab Fab in complex with L5E meditope variant | Descriptor: | Cetuximab Fab heavy chain, Cetuximab Fab light chain, L5E meditope variant, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2015-11-18 | Release date: | 2016-10-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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3GD1
| Structure of an Arrestin/Clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking | Descriptor: | Beta-arrestin-1, Clathrin heavy chain 1, clathrin | Authors: | Kang, D.S, Kern, R.C, Puthenveedu, M.A, von Zastrow, M, Williams, J.C, Benovic, J.L. | Deposit date: | 2009-02-23 | Release date: | 2009-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking J.Biol.Chem., 284, 2009
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5TH2
| Cetuximab Fab in complex with L5Q meditope variant | Descriptor: | L5Q meditope, PHOSPHATE ION, cetuximab Fab, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2016-09-28 | Release date: | 2016-10-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5U5F
| MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT IN COMPLEX WITH (Ac) CQFDA(PH)2STRRLRCGGSK | Descriptor: | 5-DIPHENYL LONG MEDITOPE, Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, ... | Authors: | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | Deposit date: | 2016-12-06 | Release date: | 2018-03-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Meditope Enabled Trastuzumab I83E Variant In Complex With (Ac)Cqfda(Ph)2Strrlrcggsk To Be Published
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5U3D
| STRUCTURE OF MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT | Descriptor: | Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, MEMAB TRASTUZUMAB FAB LIGHT CHAIN I83E, ... | Authors: | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | Deposit date: | 2016-12-01 | Release date: | 2018-03-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Meditope Enabled Trastuzumab I83E Variant To Be Published
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5T1K
| Cetuximab Fab in complex with CQFDA(Ph)2STRRLKC | Descriptor: | CETUXIMAB FAB HEAVY CHAIN, CETUXIMAB FAB LIGHT CHAIN, CQFDA(PH)2STRRLKC PEPTIDE, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2016-08-19 | Release date: | 2016-10-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5T1M
| Cetuximab Fab in complex with CQYDLSTRRLKC | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CETUXIMAB FAB HEAVY CHAIN, CETUXIMAB FAB LIGHT CHAIN, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2016-08-19 | Release date: | 2016-10-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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5T1L
| Cetuximab Fab in complex with CQA(Ph)2DLSTRRLKC peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CETUXIMAB FAB HEAVY CHAIN, CETUXIMAB FAB LIGHT CHAIN, ... | Authors: | Bzymek, K.P, Williams, J.C. | Deposit date: | 2016-08-19 | Release date: | 2016-10-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallogr F Struct Biol Commun, 72, 2016
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7JKM
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1EAS
| NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OF ORALLY ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES | Descriptor: | 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE, PORCINE PANCREATIC ELASTASE, SODIUM ION, ... | Authors: | Ceccarelli, C. | Deposit date: | 1994-11-22 | Release date: | 1995-02-07 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones. J.Med.Chem., 37, 1994
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1EAU
| NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 6. DESIGN OF A POTENT, INTRATRACHEALLY ACTIVE, PYRIDONE-BASED TRIFLUOROMETHYL KETONE | Descriptor: | 2-[5-AMINO-6-OXO-2-(2-THIENYL)-1,6-DIHYDROPYRIMIDIN-1-YL)-N-[3,3-DIFLUORO -1-ISOPROPYL-2-OXO-3-(N-(2-MORPHOLINO ETHYL)CARBAMOYL]PROPYL]ACETAMIDE, PORCINE PANCREATIC ELASTASE, SODIUM ION, ... | Authors: | Ceccarelli, C. | Deposit date: | 1994-11-22 | Release date: | 1995-02-07 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone. J.Med.Chem., 38, 1995
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1EAT
| NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5-AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES | Descriptor: | 2-[5-METHANESULFONYLAMINO-2-(4-AMINOPHENYL)-6-OXO-1,6-DIHYDRO-1-PYRIMIDINYL]-N-(3,3,3-TRIFLUORO-1-ISOPROPYL-2-OXOPROPYL)ACETAMIDE, PORCINE PANCREATIC ELASTASE, SODIUM ION, ... | Authors: | Ceccarelli, C. | Deposit date: | 1994-11-22 | Release date: | 1995-02-07 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones. J.Med.Chem., 38, 1995
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1Z9K
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2MPX
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5C39
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7UZA
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7UZ7
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7UZ5
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