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7QPN
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BU of 7qpn by Molmil
Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor and AMP-PNP
Descriptor: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C)
Authors:Howard, T.D, Ogg, D.T.
Deposit date:2022-01-05
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
J.Med.Chem., 65, 2022
7QIE
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BU of 7qie by Molmil
Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor
Descriptor: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine, Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Authors:Howard, T.D, Ogg, D.T.
Deposit date:2021-12-14
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
J.Med.Chem., 65, 2022
3COW
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BU of 3cow by Molmil
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution- in complex with sulphonamide inhibitor 2
Descriptor: 5'-O-{[(2R)-2-hydroxy-3,3-dimethylbutanoyl]sulfamoyl}adenosine, ETHANOL, GLYCEROL, ...
Authors:Ciulli, A, Chirgadze, D.Y, Blundell, T.L, Abell, C.
Deposit date:2008-03-29
Release date:2008-10-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Chembiochem, 9, 2008
3COY
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BU of 3coy by Molmil
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.05 Ang resolution- in complex with sulphonamide inhibitor 3
Descriptor: 5'-O-[(3-methyl-D-valyl)sulfamoyl]adenosine, ETHANOL, GLYCEROL, ...
Authors:Ciulli, A, Chirgadze, D.Y, Blundell, T.L, Abell, C.
Deposit date:2008-03-29
Release date:2008-10-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Chembiochem, 9, 2008
3COV
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BU of 3cov by Molmil
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.5 Ang resolution- apo form
Descriptor: ETHANOL, GLYCEROL, Pantothenate synthetase, ...
Authors:Ciulli, A, Chirgadze, D.Y, Blundell, T.L, Abell, C.
Deposit date:2008-03-29
Release date:2008-10-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Chembiochem, 9, 2008
3COZ
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BU of 3coz by Molmil
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 2.0 Ang resolution- in complex with sulphonamide inhibitor 4
Descriptor: 5'-O-(D-valylsulfamoyl)adenosine, ETHANOL, GLYCEROL, ...
Authors:Ciulli, A, Chirgadze, D.Y, Blundell, T.L, Abell, C.
Deposit date:2008-03-29
Release date:2008-10-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Chembiochem, 9, 2008
4D6P
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BU of 4d6p by Molmil
RADA C-TERMINAL ATPASE DOMAIN FROM PYROCOCCUS FURIOSUS BOUND TO AMPPNP
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, GLYCEROL, MAGNESIUM ION, ...
Authors:Marsh, M.E, Ehebauer, M.T, Scott, D, Abell, C, Blundell, T.L, Hyvonen, M.
Deposit date:2014-11-13
Release date:2015-01-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.482 Å)
Cite:ATP Half-Sites in Rada and Rad51 Recombinases Bind Nucleotides
FEBS Open Bio, 6, 2016
5FOS
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BU of 5fos by Molmil
HUMANISED MONOMERIC RADA IN COMPLEX WITH OLIGOMERISATION PEPTIDE
Descriptor: DNA REPAIR AND RECOMBINATION PROTEIN RADA, GLYCEROL, PHOSPHATE ION
Authors:Sharpe, T, Moschetti, T, Fischer, G, Marsh, M, Blundell, T.L, Abell, C, Hyvonen, M.
Deposit date:2015-11-26
Release date:2016-10-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
6XUJ
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BU of 6xuj by Molmil
HumRadA1 in complex with 5-Ethyl-N-(1H-indol-5-ylmethyl)-1,3,4-thiadiazol-2-amine in P21212
Descriptor: 5-Ethyl-N-(1H-indol-5-ylmethyl)-1,3,4-thiadiazol-2-amine, DNA repair and recombination protein RadA, PHOSPHATE ION
Authors:Marsh, M.E, Scott, D.E, Hyvonen, M.
Deposit date:2020-01-20
Release date:2021-03-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Optimising crystallographic systems for structure-guided drug discovery
To be published
6XUF
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BU of 6xuf by Molmil
HumRadA1 in complex with 5-Ethyl-N-(1H-indol-5-ylmethyl)-1,3,4-thiadiazol-2-amine in P21
Descriptor: 5-Ethyl-N-(1H-indol-5-ylmethyl)-1,3,4-thiadiazol-2-amine, DNA repair and recombination protein RadA, PHOSPHATE ION
Authors:Marsh, M.E, Scott, D.E, Hyvonen, M.E.
Deposit date:2020-01-19
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.241 Å)
Cite:Optimising crystallographic systems for structure-guided drug discovery
To be published
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数据于2024-09-18公开中

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