PDB Search results for query - Protein Data Bank Japan

PDB: 3 results

Crystal Structure of Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PI5P4Ka) bound to an inhibitor
Descriptor:	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, ~{N}-(3-chloranyl-4-methoxy-phenyl)-7-(3,4-dimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine
Authors:	Harborne, S.P.D, Howard, T.D, Ogg, D.T.
Deposit date:	2023-01-19
Release date:	2023-04-26
Last modified:	2023-06-07
Method:	X-RAY DIFFRACTION (2.096 Å)
Cite:	Identification of ARUK2002821 as an isoform-selective PI5P4K alpha inhibitor. Rsc Med Chem, 14, 2023

Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor and AMP-PNP
Descriptor:	5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C)
Authors:	Howard, T.D, Ogg, D.T.
Deposit date:	2022-01-05
Release date:	2022-05-18
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J.Med.Chem., 65, 2022

Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor
Descriptor:	5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine, Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Authors:	Howard, T.D, Ogg, D.T.
Deposit date:	2021-12-14
Release date:	2022-05-18
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (2.39 Å)
Cite:	Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase gamma Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J.Med.Chem., 65, 2022