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Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.5 A resolution with (2-ETHYLPHENYL)METHANOL bound
Descriptor:	(2-ETHYLPHENYL)METHANOL, GLYCEROL, Nucleoside 2-deoxyribosyltransferase, ...
Authors:	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-11-28
Release date:	2005-12-06
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

2F2T

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.7 A resolution with 5-Aminoisoquinoline bound
Descriptor:	GLYCEROL, ISOQUINOLIN-5-AMINE, Nucleoside 2-deoxyribosyltransferase, ...
Authors:	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-11-17
Release date:	2005-11-22
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

2Q0X

Alpha/Beta hydrolase fold protein of unknown function
Descriptor:	GLYCEROL, Uncharacterized protein
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-05-22
Release date:	2007-06-26
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function. Acta Crystallogr.,Sect.F, 64, 2008

3BNW

Crystal structure of riboflavin kinase from Trypanosoma brucei
Descriptor:	Riboflavin kinase, putative
Authors:	Merritt, E.A, Holmes, M, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-12-14
Release date:	2008-01-08
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Riboflavin kinase from Trypanosoma brucei. To be Published

1YJ8

Initial structural analysis of Plasmodium falciparum Glycerol-3-phosphate dehydrogenase
Descriptor:	glycerol-3-phosphate dehydrogenase
Authors:	Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-01-13
Release date:	2005-02-01
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.85 Å)
Cite:	Initial structural analysis of Plasmodium falciparum Glycerol-3-phosphate dehydrogenase To be Published

3BJE

Crystal structure of Trypanosoma brucei nucleoside phosphorylase shows uridine phosphorylase activity
Descriptor:	1-O-phosphono-alpha-D-ribofuranose, CALCIUM ION, Nucleoside phosphorylase, ...
Authors:	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-12-03
Release date:	2007-12-18
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.44 Å)
Cite:	The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase J.Mol.Biol., 396, 2010

2F84

Crystal Structure of an orotidine-5'-monophosphate decarboxylase homolog from P.falciparum
Descriptor:	PHOSPHATE ION, orotidine monophosphate decarboxylase
Authors:	Caruthers, J.M, Robein, M, Merritt, E.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-12-01
Release date:	2005-12-20
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal Structure of an orotidine-5'-monophosphate decarboxylase homolog from Plasmodium falciparum To be Published

3C61

Crystal structure of dihydroorotate dehydrogenase from Leishmania donovani
Descriptor:	(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, AZIDE ION, CHLORIDE ION, ...
Authors:	Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2008-02-01
Release date:	2008-02-26
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Dihydroorotate dehydrogenase from Leishmania donovani. To be Published

3BWC

Crystal structure of spermidine synthase from Trypanosoma cruzi in complex with SAM at 2.3 A resolution
Descriptor:	BETA-MERCAPTOETHANOL, S-ADENOSYLMETHIONINE, Spermidine synthase
Authors:	Bosch, J, Arakaki, T.L, Le Trong, I, Merritt, E.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2008-01-09
Release date:	2008-04-01
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structure of spermidine synthase from Trypanosoma cruzi. To be Published

3DWR

Leishmania major coproporphyrinogen III oxidase with bound ligand
Descriptor:	ACETATE ION, Coproporphyrinogen III oxidase, cyclopentylacetic acid
Authors:	Le Trong, I, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2008-07-22
Release date:	2008-09-09
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.66 Å)
Cite:	Leishmania major coproporphyrinogen III oxidase with bound ligand To be Published

2PC4

Crystal structure of fructose-bisphosphate aldolase from Plasmodium falciparum in complex with TRAP-tail determined at 2.4 angstrom resolution
Descriptor:	Fructose-bisphosphate aldolase, PbTRAP
Authors:	Bosch, J, Buscaglia, C.A, Krumm, B, Cardozo, T, Nussenzweig, V, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-03-29
Release date:	2007-04-17
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite. Proc.Natl.Acad.Sci.Usa, 104, 2007

3DWS

Leishmania major Coproporphyrinogen III Oxidase with bound ligand
Descriptor:	5-fluoroindole-2-carboxylic acid, ACETATE ION, Coproporphyrinogen III oxidase
Authors:	Le Trong, I, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2008-07-22
Release date:	2008-09-09
Last modified:	2017-10-25
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Leishmania major Coproporphyrinogen III Oxidase with bound ligand To be Published

1SQ6

Plasmodium falciparum homolog of Uridine phosphorylase/Purine nucleoside phosphorylase
Descriptor:	SULFATE ION, uridine phosphorylase, putative
Authors:	Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-03-17
Release date:	2004-04-06
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine. Acta Crystallogr.,Sect.D, 61, 2005

1R75

Leishmania major hypothetical protein
Descriptor:	GLYCEROL, hypothetical protein
Authors:	Han, G.W, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2003-10-17
Release date:	2003-12-02
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.86 Å)
Cite:	LEISHMANIA MAJOR HYPOTHETICAL PROTEIN To be Published

1ZSO

Hypothetical protein from plasmodium falciparum
Descriptor:	hypothetical protein
Authors:	Holmes, M.A, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-05-24
Release date:	2005-06-07
Last modified:	2017-10-11
Method:	X-RAY DIFFRACTION (2.17 Å)
Cite:	Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum. Acta Crystallogr.,Sect.F, 62, 2006

1X9G

PUTATIVE MAR1 RIBONUCLEASE FROM LEISHMANIA DONOVANI
Descriptor:	PUTATIVE MAR1
Authors:	Caruthers, J, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-08-20
Release date:	2004-09-07
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.41 Å)
Cite:	Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci., 14, 2005

1XN4

PUTATIVE MAR1 RIBONUCLEASE FROM LEISHMANIA MAJOR
Descriptor:	ribonuclease MAR1
Authors:	Caruthers, J, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-10-04
Release date:	2004-10-12
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (3.8 Å)
Cite:	Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci., 14, 2005

1VJQ

Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability.
Descriptor:	designed protein
Authors:	Merritt, E.A, Baker, D, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-03-19
Release date:	2004-03-30
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.098 Å)
Cite:	Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability. To be Published

1YZV

HYPOTHETICAL PROTEIN FROM TRYPANOSOMA CRUZI
Descriptor:	HYPOTHETICAL PROTEIN, SULFATE ION
Authors:	Caruthers, J, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-02-28
Release date:	2005-03-08
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.001 Å)
Cite:	Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci., 14, 2005

2A0K

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.8 A resolution
Descriptor:	GLYCEROL, Nucleoside 2-deoxyribosyltransferase, SULFATE ION
Authors:	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-06-16
Release date:	2005-07-26
Last modified:	2021-10-20
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

2HQJ

Cyclophilin from Leishmania major
Descriptor:	PHOSPHATE ION, Peptidyl-prolyl cis-trans isomerase
Authors:	Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2006-07-18
Release date:	2006-07-25
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Cyclophilin from Leishmania major To be Published

2F64

Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.6 A resolution with 1-METHYLQUINOLIN-2(1H)-ONE bound
Descriptor:	1-METHYLQUINOLIN-2(1H)-ONE, GLYCEROL, Nucleoside 2-deoxyribosyltransferase, ...
Authors:	Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-11-28
Release date:	2005-12-06
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J.Med.Chem., 49, 2006

2GZQ

Phosphatidylethanolamine-binding protein from Plasmodium vivax
Descriptor:	Phosphatidylethanolamine-binding protein
Authors:	Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2006-05-11
Release date:	2006-05-23
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix Acta Crystallogr.,Sect.F, 63, 2007

2F8M

Ribose 5-phosphate isomerase from Plasmodium falciparum
Descriptor:	PHOSPHATE ION, ribose 5-phosphate isomerase
Authors:	Holmes, M.A, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2005-12-02
Release date:	2005-12-27
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.087 Å)
Cite:	Structure of ribose 5-phosphate isomerase from Plasmodium falciparum. Acta Crystallogr.,Sect.F, 62, 2006

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