4JM4
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![BU of 4jm4 by Molmil](/molmil-images/mine/4jm4) | Crystal Structure of PGT 135 Fab | Descriptor: | PGT 135 Heavy Chain, PGT 135 Light Chain | Authors: | Kong, L, Wilson, I.A. | Deposit date: | 2013-03-13 | Release date: | 2013-05-29 | Last modified: | 2013-07-17 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat.Struct.Mol.Biol., 20, 2013
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4JPJ
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![BU of 4jpj by Molmil](/molmil-images/mine/4jpj) | Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 | Authors: | Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A. | Deposit date: | 2013-03-19 | Release date: | 2013-04-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013
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5VJM
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![BU of 5vjm by Molmil](/molmil-images/mine/5vjm) | Crystal structure of H7 hemagglutinin mutant (V186K, K193T, G228S) from the influenza virus A/Shanghai/2/2013 (H7N9) with LSTa | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2, ... | Authors: | Zhu, X, Wilson, I.A. | Deposit date: | 2017-04-19 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.909 Å) | Cite: | Three mutations switch H7N9 influenza to human-type receptor specificity. PLoS Pathog., 13, 2017
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5W42
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![BU of 5w42 by Molmil](/molmil-images/mine/5w42) | |
4L1T
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![BU of 4l1t by Molmil](/molmil-images/mine/4l1t) | |
4I78
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![BU of 4i78 by Molmil](/molmil-images/mine/4i78) | |
5VTR
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![BU of 5vtr by Molmil](/molmil-images/mine/5vtr) | |
5VU4
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![BU of 5vu4 by Molmil](/molmil-images/mine/5vu4) | |
4JY6
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![BU of 4jy6 by Molmil](/molmil-images/mine/4jy6) | Crystal structure of human Fab PGT123, a broadly reactive and potent HIV-1 neutralizing antibody | Descriptor: | GLYCEROL, PGT123 heavy chain, PGT123 light chain, ... | Authors: | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | Deposit date: | 2013-03-29 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans. Plos Pathog., 9, 2013
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5WDU
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![BU of 5wdu by Molmil](/molmil-images/mine/5wdu) | HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | Authors: | Julien, J.-P, Torrents de la Pena, A, Sanders, R.W, Wilson, I.A. | Deposit date: | 2017-07-06 | Release date: | 2018-04-04 | Last modified: | 2022-11-30 | Method: | X-RAY DIFFRACTION (7 Å) | Cite: | Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization. Cell Rep, 20, 2017
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4L1S
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![BU of 4l1s by Molmil](/molmil-images/mine/4l1s) | |
5UI4
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![BU of 5ui4 by Molmil](/molmil-images/mine/5ui4) | Structure of NME1 covalently conjugated to imidazole fluorosulfate | Descriptor: | 4-[4-(3-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-5-yl]phenyl sulfurofluoridate, Nucleoside diphosphate kinase A | Authors: | Mortenson, D.E, Brighty, G.J, Wilson, I.A, Kelly, J.W. | Deposit date: | 2017-01-12 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. J. Am. Chem. Soc., 140, 2018
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4K3G
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![BU of 4k3g by Molmil](/molmil-images/mine/4k3g) | |
5UM8
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![BU of 5um8 by Molmil](/molmil-images/mine/5um8) | Crystal structure of HIV-1 envelope trimer 16055 NFL TD CC (T569G) in complex with Fabs 35022 and PGT124 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 35022 heavy chain, ... | Authors: | Garces, F, Stanfield, R.L, Wilson, I.A. | Deposit date: | 2017-01-26 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.935 Å) | Cite: | Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein. Immunity, 46, 2017
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4KY2
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![BU of 4ky2 by Molmil](/molmil-images/mine/4ky2) | Transthyretin in complex with the fluorescent folding sensor (E)-7-hydroxy-3-(4-hydroxy-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one | Descriptor: | 7-hydroxy-3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]-4-methyl-2H-chromen-2-one, Transthyretin | Authors: | Connelly, S, Wilson, I.A, Choi, S. | Deposit date: | 2013-05-28 | Release date: | 2013-08-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors. Chem.Commun.(Camb.), 49, 2013
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4LG2
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![BU of 4lg2 by Molmil](/molmil-images/mine/4lg2) | Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA | Descriptor: | Polymerase cofactor, dsRNA | Authors: | Bale, S, Julien, J.-P, Bornholdt, Z.A, Krois, A.S, Wilson, I.A, Saphire, E.O. | Deposit date: | 2013-06-27 | Release date: | 2013-07-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism. J.Virol., 87, 2013
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4K3Y
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![BU of 4k3y by Molmil](/molmil-images/mine/4k3y) | |
5XRS
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![BU of 5xrs by Molmil](/molmil-images/mine/5xrs) | |
5XRT
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![BU of 5xrt by Molmil](/molmil-images/mine/5xrt) | Crystal structure of A/Minnesota/11/2010 (H3N2) influenza virus hemagglutinin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhang, H, Wilson, I.A. | Deposit date: | 2017-06-09 | Release date: | 2018-07-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun, 9, 2018
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4MHJ
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![BU of 4mhj by Molmil](/molmil-images/mine/4mhj) | |
4JY5
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![BU of 4jy5 by Molmil](/molmil-images/mine/4jy5) | Crystal structure of human Fab PGT122, a broadly reactive and potent HIV-1 neutralizing antibody | Descriptor: | GLYCEROL, PGT122 heavy chain, PGT122 light chain | Authors: | Julien, J.-P, Diwanji, D.C, Burton, D.R, Wilson, I.A. | Deposit date: | 2013-03-29 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. Plos Pathog., 9, 2013
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4M5Z
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![BU of 4m5z by Molmil](/molmil-images/mine/4m5z) | Crystal structure of broadly neutralizing antibody 5J8 bound to 2009 pandemic influenza hemagglutinin, HA1 subunit | Descriptor: | Fab 5J8 heavy chain, Fab 5J8 light chain, Hemagglutinin HA1 chain | Authors: | Hong, M, Lee, P.S, Wilson, I.A. | Deposit date: | 2013-08-08 | Release date: | 2013-09-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site. J.Virol., 87, 2013
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4M6L
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![BU of 4m6l by Molmil](/molmil-images/mine/4m6l) | Crystal structure of human dihydrofolate reductase (DHFR) bound to NADP+ and 5,10-dideazatetrahydrofolic acid | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Dihydrofolate reductase, N-(4-{2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid, ... | Authors: | Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A. | Deposit date: | 2013-08-09 | Release date: | 2013-09-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20, 2013
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4M5Y
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![BU of 4m5y by Molmil](/molmil-images/mine/4m5y) | Crystal structure of broadly neutralizing Fab 5J8 | Descriptor: | DI(HYDROXYETHYL)ETHER, Fab 5J8 heavy chain, Fab 5J8 light chain, ... | Authors: | Lee, P.S, Wilson, I.A. | Deposit date: | 2013-08-08 | Release date: | 2013-09-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site. J.Virol., 87, 2013
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4M6J
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![BU of 4m6j by Molmil](/molmil-images/mine/4m6j) | Crystal structure of human dihydrofolate reductase (DHFR) bound to NADPH | Descriptor: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A. | Deposit date: | 2013-08-09 | Release date: | 2013-09-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.201 Å) | Cite: | Divergent evolution of protein conformational dynamics in dihydrofolate reductase. Nat.Struct.Mol.Biol., 20, 2013
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