4G2W
| Crystal structure of PDE5A in complex with its inhibitor | Descriptor: | 5,6-diethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Ren, J, Chen, T.T, Xu, Y.C. | Deposit date: | 2012-07-13 | Release date: | 2013-06-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. J.Med.Chem., 55, 2012
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4DOU
| Crystal Structure of a Single-chain Trimer of Human Adiponectin Globular Domain | Descriptor: | 1,2-ETHANEDIOL, Adiponectin, CALCIUM ION, ... | Authors: | Min, X, Walker, N.P, Wang, Z. | Deposit date: | 2012-02-10 | Release date: | 2012-02-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a single-chain trimer of human adiponectin globular domain. Febs Lett., 586, 2012
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4G2Y
| Crystal structure of PDE5A complexed with its inhibitor | Descriptor: | 2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Ren, J, Chen, T.T, Xu, Y.C. | Deposit date: | 2012-07-13 | Release date: | 2013-06-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. J.Med.Chem., 55, 2012
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4HKB
| CH67 Fab (unbound) from the CH65-67 Lineage | Descriptor: | CH67 heavy chain, CH67 light chain | Authors: | Schmidt, A.G, Harrison, S.C. | Deposit date: | 2012-10-15 | Release date: | 2012-11-21 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HK0
| UCA Fab (unbound) from CH65-CH67 Lineage | Descriptor: | UCA heavy chain, UCA light chain | Authors: | Schmidt, A.G, Harrison, S.C. | Deposit date: | 2012-10-14 | Release date: | 2012-11-21 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.497 Å) | Cite: | Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HK3
| I2 Fab (unbound) from CH65-CH67 Lineage | Descriptor: | I2 heavy chain, I2 light chain | Authors: | Schmidt, A.G, Harrison, S.C. | Deposit date: | 2012-10-14 | Release date: | 2012-11-21 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc.Natl.Acad.Sci.USA, 110, 2013
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4HKX
| Influenza hemagglutinin in complex with CH67 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CH67 heavy chain, CH67 light chain, ... | Authors: | Schmidt, A.G, Harrison, S.C. | Deposit date: | 2012-10-15 | Release date: | 2012-11-21 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JDK
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4JDI
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4JDJ
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4JDH
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6IE1
| Crystal Structure of ELMO2(Engulfment and cell motility protein 2) | Descriptor: | Engulfment and cell motility protein 2, GLYCEROL | Authors: | Weng, Z.F, Lin, L, Zhang, R.G, Zhu, J.W. | Deposit date: | 2018-09-12 | Release date: | 2019-01-23 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds Nat Commun, 10, 2019
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4KIN
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4KIP
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4KIQ
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4KS8
| PAK6 kinase domain in complex with sunitinib | Descriptor: | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, Serine/threonine-protein kinase PAK 6 | Authors: | Gao, J, Boggon, T.J. | Deposit date: | 2013-05-17 | Release date: | 2013-09-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6. Plos One, 8, 2013
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4KS7
| PAK6 kinase domain in complex with PF-3758309 | Descriptor: | ISOPROPYL ALCOHOL, PF-3758309, Serine/threonine-protein kinase PAK 6 | Authors: | Gao, J, Boggon, T.J. | Deposit date: | 2013-05-17 | Release date: | 2013-09-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6. Plos One, 8, 2013
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7YTE
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7YTD
| Cryo-EM structure of four human FcmR bound to IgM-Fc/J | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, Immunoglobulin J chain, ... | Authors: | Li, Y, Shen, H, Xiao, J. | Deposit date: | 2022-08-14 | Release date: | 2023-02-01 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Immunoglobulin M perception by Fc mu R. Nature, 615, 2023
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7YTC
| Cryo-EM structure of human FcmR bound to IgM-Fc/J | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, Immunoglobulin J chain, ... | Authors: | Li, Y, Shen, H, Xiao, J. | Deposit date: | 2022-08-14 | Release date: | 2023-02-01 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Immunoglobulin M perception by Fc mu R. Nature, 615, 2023
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7YSG
| Cryo-EM structure of human FcmR bound to sIgM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | Authors: | Li, Y, Shen, H, Xiao, J. | Deposit date: | 2022-08-12 | Release date: | 2023-02-01 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Immunoglobulin M perception by Fc mu R. Nature, 615, 2023
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8J6O
| transport T2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Green fluorescent protein (Fragment),SID1 transmembrane family member 2, ... | Authors: | Jiang, D.H, Zhang, J.T. | Deposit date: | 2023-04-26 | Release date: | 2024-05-01 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural insights into double-stranded RNA recognition and transport by SID-1. Nat.Struct.Mol.Biol., 31, 2024
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8J6M
| SIDT1 protein | Descriptor: | CHOLESTEROL, Green fluorescent protein,SID1 transmembrane family member 1, OLEIC ACID, ... | Authors: | Zhang, J.T, Jiang, D.H. | Deposit date: | 2023-04-26 | Release date: | 2024-05-01 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Structural insights into double-stranded RNA recognition and transport by SID-1. Nat.Struct.Mol.Biol., 31, 2024
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5UF7
| CRYSTAL STRUCTURE OF MUNC13-1 MUN DOMAIN | Descriptor: | Protein unc-13 homolog A | Authors: | Tomchick, D.R, Rizo, J, Xu, J. | Deposit date: | 2017-01-03 | Release date: | 2017-02-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.896 Å) | Cite: | Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN. Elife, 6, 2017
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7FJN
| Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, T6 heavy chain, ... | Authors: | Wang, X, Zhang, L, Zhang, S, Liang, Q. | Deposit date: | 2021-08-04 | Release date: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants. Iscience, 25, 2022
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