7EYM
 
 | | Crystal structure of Vibrio cholerae ppnP | | Descriptor: | Pyrimidine/purine nucleoside phosphorylase | | Authors: | Wen, Y, Wu, B.X. | | Deposit date: | 2021-05-31 | | Release date: | 2022-02-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Crystal structures of a new class of pyrimidine/purine nucleoside phosphorylase revealed a Cupin fold.
Proteins, 90, 2022
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8JWY
 | | Crystal structure of A2AR-T4L in complex with 2-118 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[2-oxidanylidene-1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]pyridin-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, Adenosine receptor A2a,Endolysin, ... | | Authors: | Weng, Y, Chen, Y, Xu, Y, Song, G. | | Deposit date: | 2023-06-29 | | Release date: | 2023-08-16 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A 2 receptors.
Sci China Life Sci, 67, 2024
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8JWZ
 | | Crystal structure of A2AR-T4L in complex with AB928 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, Adenosine receptor A2a,Endolysin, ... | | Authors: | Weng, Y, Chen, Y, Xu, Y, Song, G. | | Deposit date: | 2023-06-29 | | Release date: | 2023-08-16 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A 2 receptors.
Sci China Life Sci, 67, 2024
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6IS2
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6IS3
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6IS1
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6IS4
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6UZT
 | | Crystal Structure of RPTP alpha | | Descriptor: | Receptor-type tyrosine-protein phosphatase alpha | | Authors: | Santelli, E, Wen, Y, Yang, S, Svensson, M.N.D, Stanford, S.M, Bottini, N. | | Deposit date: | 2019-11-15 | | Release date: | 2020-03-18 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | RPTP alpha phosphatase activity is allosterically regulated by the membrane-distal catalytic domain.
J.Biol.Chem., 295, 2020
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6LNP
 | | Crystal structure of citrate Biosensor | | Descriptor: | CITRIC ACID, Fusion protein of Green fluorescent protein and Sensor histidine kinase CitA | | Authors: | Wen, Y, Campbell, R. | | Deposit date: | 2019-12-31 | | Release date: | 2020-05-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.993 Å) | | Cite: | High-Performance Intensiometric Direct- and Inverse-Response Genetically Encoded Biosensors for Citrate.
Acs Cent.Sci., 6, 2020
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8GRA
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8H3X
 | | Bacteroide Fragilis Toxin in complex with nanobody 282 | | Descriptor: | Fragilysin, ZINC ION, nanobody 282 | | Authors: | Wen, Y, Guo, Y. | | Deposit date: | 2022-10-09 | | Release date: | 2023-02-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Screening and epitope characterization of diagnostic nanobody against total and activated Bacteroides fragilis toxin.
Front Immunol, 14, 2023
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8H3Y
 | | Bacteroide Fragilis Toxin in complex with nanobody 327 | | Descriptor: | Fragilysin, Nanobody 327, ZINC ION | | Authors: | Wen, Y, Guo, Y. | | Deposit date: | 2022-10-09 | | Release date: | 2023-02-08 | | Last modified: | 2023-03-15 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Screening and epitope characterization of diagnostic nanobody against total and activated Bacteroides fragilis toxin.
Front Immunol, 14, 2023
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7VCM
 | | crystal structure of GINKO1 | | Descriptor: | Green fluorescent protein,Potassium binding protein Kbp,Green fluorescent protein, POTASSIUM ION | | Authors: | Wen, Y, Campbell, R.E, Lemieux, M.J. | | Deposit date: | 2021-09-03 | | Release date: | 2022-07-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life.
Plos Biol., 20, 2022
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6JJJ
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7CNU
 | | Crystal structure of DLC2 in complex with BMF peptide | | Descriptor: | Bcl-2-modifying factor, Dynein light chain 2, cytoplasmic | | Authors: | Wen, Y, Shao, Y. | | Deposit date: | 2020-08-03 | | Release date: | 2021-08-11 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Non-canonical phosphorylation of Bmf by p38 MAPK promotes its apoptotic activity in anoikis.
Cell Death Differ., 29, 2022
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7E9Y
 | | Crystal structure of eLACCO1 | | Descriptor: | (2S)-2-HYDROXYPROPANOIC ACID, CALCIUM ION, Lactate-binding periplasmic protein TTHA0766,Lactate-binding periplasmic protein TTHA0766 | | Authors: | Wen, Y, Campbell, R.E, Lemieux, M.J, Nasu, Y. | | Deposit date: | 2021-03-05 | | Release date: | 2021-12-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | A genetically encoded fluorescent biosensor for extracellular L-lactate.
Nat Commun, 12, 2021
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7DNA
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7DMX
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7DNB
 | | Crystal structure of PhoCl barrel | | Descriptor: | PhoCl Barrel, SODIUM ION | | Authors: | Wen, Y, Lemieux, J.M. | | Deposit date: | 2020-12-09 | | Release date: | 2021-01-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Photocleavable proteins that undergo fast and efficient dissociation.
Chem Sci, 12, 2021
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7CCH
 | | Acinetobacter baumannii histidine kinase AdeS | | Descriptor: | AdeS | | Authors: | Wen, Y, Felix, J. | | Deposit date: | 2020-06-17 | | Release date: | 2021-06-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.848 Å) | | Cite: | Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS.
Iscience, 24, 2021
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7CCI
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7YW0
 | | Bacteroides fragilis Hcp5 | | Descriptor: | Bacterodales T6SS protein TssD (Hcp) | | Authors: | Wen, Y, He, W, Bai, Y. | | Deposit date: | 2022-08-20 | | Release date: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structure and assembly of type VI secretion system cargo delivery vehicle.
Cell Rep, 42, 2023
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7YV3
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7YV5
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5MJ4
 | | INTERLEUKIN-23 COMPLEX WITH AN ANTAGONISTIC ALPHABODY, CRYSTAL FORM 2 | | Descriptor: | ALPHABODY MA12, Interleukin-12 subunit beta, Interleukin-23 subunit alpha, ... | | Authors: | Desmet, J, Verstraete, K, Bloch, Y, Lorent, E, Wen, Y, Devreese, B, Vandenbroucke, K, Loverix, S, Hettmann, T, Deroo, S, Somers, K, Henderikx, P, Lasters, I, Savvides, S. | | Deposit date: | 2016-11-29 | | Release date: | 2017-01-11 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | STRUCTURAL BASIS OF IL-23 ANTAGONISM BY AN ALPHABODY PROTEIN
Nature Communications, 5, 2014
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