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6MY0
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BU of 6my0 by Molmil
Structure of 53BP1 Tandem Tudor domains with E1549P and D1550N mutations
Descriptor: TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MXX
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BU of 6mxx by Molmil
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991
Descriptor: FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-iodobenzamide, PHOSPHATE ION, ...
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.298 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
4UVA
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BU of 4uva by Molmil
LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1R,2S)
Descriptor: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS)-4a-[(1S,3E)-3-imino-1-phenylbutyl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate
Authors:Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C.
Deposit date:2014-08-05
Release date:2014-09-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
3F1I
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BU of 3f1i by Molmil
Human ESCRT-0 Core Complex
Descriptor: Hepatocyte growth factor-regulated tyrosine kinase substrate, Signal transducing adapter molecule 1
Authors:Ren, X, Kloer, D.P, Kim, Y, Ghirlando, R, Saidi, L, Hummer, G, Hurley, J.H.
Deposit date:2008-10-28
Release date:2009-03-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Hybrid Structural Model of the Complete Human ESCRT-0 Complex.
Structure, 17, 2009
7LYA
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BU of 7lya by Molmil
Cryo-EM structure of the human nucleosome core particle with linked histone proteins H2A and H2B
Descriptor: DNA (146-MER), DNA (147-MER), Histone H2A type 1-B/E, ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
Deposit date:2021-03-06
Release date:2021-07-28
Last modified:2021-09-01
Method:ELECTRON MICROSCOPY (2.91 Å)
Cite:Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
7LYB
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BU of 7lyb by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c
Descriptor: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
Deposit date:2021-03-06
Release date:2021-07-28
Last modified:2021-09-01
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
7LYC
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BU of 7lyc by Molmil
Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777)
Descriptor: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
Deposit date:2021-03-06
Release date:2021-06-16
Last modified:2021-09-01
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
4V2C
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BU of 4v2c by Molmil
mouse FLRT2 LRR domain in complex with rat Unc5D Ig1 domain
Descriptor: FIBRONECTIN LEUCINE RICH TRANSMEMBRANE PROTEIN 2, PROTEIN UNC5D
Authors:Seiradake, E, del Toro, D, Nagel, D, Cop, F, Haertl, R, Ruff, T, Seyit-Bremer, G, Harlos, K, Border, E.C, Acker-Palmer, A, Jones, E.Y, Klein, R.
Deposit date:2014-10-08
Release date:2014-11-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (4 Å)
Cite:Flrt Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development
Neuron, 84, 2014
4V2E
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BU of 4v2e by Molmil
FLRT3 LRR domain
Descriptor: FIBRONECTIN LEUCINE RICH TRANSMEMBRANE PROTEIN 3
Authors:Seiradake, E, del Toro, D, Nagel, D, Cop, F, Haertl, R, Ruff, T, Seyit-Bremer, G, Harlos, K, Border, E.C, Acker-Palmer, A, Jones, E.Y, Klein, R.
Deposit date:2014-10-08
Release date:2014-11-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Flrt Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development.
Neuron, 84, 2014
6MXY
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BU of 6mxy by Molmil
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351
Descriptor: N-[3-(tert-butylamino)propyl]-3-(trifluoromethyl)benzamide, PHOSPHATE ION, TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.624 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MXZ
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BU of 6mxz by Molmil
Structure of 53BP1 Tudor domains in complex with small molecule UNC3474
Descriptor: FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide, TP53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Schuller, D.J, Mer, G.
Deposit date:2018-10-31
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6D0L
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BU of 6d0l by Molmil
Structure of human TIRR
Descriptor: Tudor-interacting repair regulator protein
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-04-10
Release date:2018-06-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Nat. Struct. Mol. Biol., 25, 2018
6CO2
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BU of 6co2 by Molmil
Structure of an engineered protein (NUDT16TI) in complex with 53BP1 Tudor domains
Descriptor: NUDT16-Tudor-interacting (NUDT16TI), TP53-binding protein 1
Authors:Botuyan, M.V, Thompson, J.R, Cui, G, Mer, G.
Deposit date:2018-03-10
Release date:2018-06-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Nat. Struct. Mol. Biol., 25, 2018
6CO1
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BU of 6co1 by Molmil
Structure of human TIRR in complex with 53BP1 Tudor domains
Descriptor: TP53-binding protein 1, Tudor-interacting repair regulator protein
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2018-03-10
Release date:2018-06-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.179 Å)
Cite:Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.
Nat. Struct. Mol. Biol., 25, 2018
7LXD
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BU of 7lxd by Molmil
Structure of yeast DNA Polymerase Zeta (apo)
Descriptor: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ...
Authors:Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R.
Deposit date:2021-03-03
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
4X45
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BU of 4x45 by Molmil
Crystal Structure of F173G Mutant of Human APRT
Descriptor: ADENOSINE MONOPHOSPHATE, Adenine phosphoribosyltransferase
Authors:Pereira, H.M, Pimenta, A, Mercaldi, G, Thiemann, O.H.
Deposit date:2014-12-02
Release date:2015-12-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of F173G Mutant of Human APRT
To Be Published
5TBN
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BU of 5tbn by Molmil
Solution NMR structure of PHF20 PHD domain in complex with a histone H3K4me2 peptide
Descriptor: Histone H3.1, PHD finger protein 20, ZINC ION
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2016-09-12
Release date:2016-10-12
Last modified:2019-12-04
Method:SOLUTION NMR
Cite:PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Cell Rep, 17, 2016
3FSS
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BU of 3fss by Molmil
Structure of the tandem PH domains of Rtt106
Descriptor: GLYCEROL, Histone chaperone RTT106, MALONIC ACID
Authors:Su, D, Thompson, J.R, Mer, G.
Deposit date:2009-01-11
Release date:2009-12-22
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.432 Å)
Cite:Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.
Nature, 483, 2012
4V5B
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BU of 4v5b by Molmil
Structure of PDF binding helix in complex with the ribosome.
Descriptor: 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ...
Authors:Bingel-Erlenmeyer, R, Kohler, R, Kramer, G, Sandikci, A, Antolic, S, Maier, T, Schaffitzel, C, Wiedmann, B, Bukau, B, Ban, N.
Deposit date:2007-11-22
Release date:2014-07-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.74 Å)
Cite:A Peptide Deformylase-Ribosome Complex Reveals Mechanism of Nascent Chain Processing.
Nature, 452, 2008
4X44
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BU of 4x44 by Molmil
Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase
Descriptor: ADENOSINE MONOPHOSPHATE, Adenine phosphoribosyltransferase, GLYCEROL, ...
Authors:Pimenta, A, Pereira, H.M, Mercaldi, G, Thiemann, O.H.
Deposit date:2014-12-02
Release date:2015-12-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.0535 Å)
Cite:Crystal Structure of Mutant R89Q of human Adenine phosphoribosyltransferase
To Be Published
8U14
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BU of 8u14 by Molmil
Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 2)
Descriptor: DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
Deposit date:2023-08-30
Release date:2024-01-17
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
8U13
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BU of 8u13 by Molmil
Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 1)
Descriptor: DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
Deposit date:2023-08-30
Release date:2024-01-17
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
3TW1
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BU of 3tw1 by Molmil
Structure of Rtt106-AHN
Descriptor: GLYCEROL, Histone chaperone RTT106, N-[2-(1H-IMIDAZOL-4-YL)ETHYL]ACETAMIDE
Authors:Su, D, Thompson, J.R, Mer, G.
Deposit date:2011-09-21
Release date:2012-02-01
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.772 Å)
Cite:Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.
Nature, 483, 2012
8SN1
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BU of 8sn1 by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 6)
Descriptor: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
Deposit date:2023-04-26
Release date:2024-01-17
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
8UPF
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BU of 8upf by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c
Descriptor: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G.
Deposit date:2023-10-22
Release date:2024-01-17
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024

221716

数据于2024-06-26公开中

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