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The Xray Crystal Structure of P. falciparum Aminopeptidase P
Descriptor:	MANGANESE (II) ION, PHOSPHATE ION, Peptidase, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2016-05-05
Release date:	2016-08-31
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum. Biochem.J., 473, 2016

5JR6

The Xray Crystal Structure of P. falciparum Aminopeptidase P in Complex With Apstatin
Descriptor:	Apstatin, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:	Drinkwater, N, McGowan, S.
Deposit date:	2016-05-05
Release date:	2016-08-31
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum. Biochem.J., 473, 2016

4EME

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase
Descriptor:	M18 aspartyl aminopeptidase, ZINC ION
Authors:	McGowan, S.
Deposit date:	2012-04-11
Release date:	2012-06-27
Last modified:	2013-01-02
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP. J.Mol.Biol., 422, 2012

4ZI6

Crystal structure of leucine aminopeptidase from Helicobacter pylori
Descriptor:	BICARBONATE ION, Cytosol aminopeptidase, SODIUM ION, ...
Authors:	Modak, J.K, Roujeinikova, A.
Deposit date:	2015-04-27
Release date:	2015-12-23
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase. Biochimie, 121, 2016

4ZLA

Bestatin complex structure of leucine aminopeptidase from Helicobacter pylori
Descriptor:	2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, BICARBONATE ION, Cytosol aminopeptidase, ...
Authors:	Modak, J.K, Roujeinikova, A.
Deposit date:	2015-05-01
Release date:	2015-12-23
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase. Biochimie, 121, 2016

4R5V

Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Descriptor:	GLYCEROL, M1 family aminopeptidase, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ...
Authors:	Drinkwater, N, Mcgowan, S.
Deposit date:	2014-08-22
Release date:	2014-10-29
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R7M

Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
Descriptor:	4-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, CARBONATE ION, DIMETHYL SULFOXIDE, ...
Authors:	Drinkwater, N, Mcgowan, S.
Deposit date:	2014-08-28
Release date:	2014-10-29
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.85 Å)
Cite:	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

8DKZ

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Khan, M.B, Lu, J, Young, H.S, Lemieux, M.J.
Deposit date:	2022-07-06
Release date:	2023-04-26
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8DJJ

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Khan, M.B, Lu, J, Young, H.S, Lemieux, M.J.
Deposit date:	2022-06-30
Release date:	2023-04-26
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.51 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8DI3

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J.
Deposit date:	2022-06-28
Release date:	2023-05-03
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8DKK

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J.
Deposit date:	2022-07-05
Release date:	2023-05-03
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8DK8

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Khan, M.B, Lu, J, Young, H.S, Lemieux, M.J.
Deposit date:	2022-07-04
Release date:	2023-05-17
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8DKH

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J.
Deposit date:	2022-07-05
Release date:	2023-05-03
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8DKJ

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J.
Deposit date:	2022-07-05
Release date:	2023-05-03
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (2.11 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8DKL

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J.
Deposit date:	2022-07-05
Release date:	2023-05-03
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8DMN

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J.
Deposit date:	2022-07-08
Release date:	2023-05-03
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8EJ9

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J.
Deposit date:	2022-09-16
Release date:	2023-04-26
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

8EJ7

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates
Descriptor:	3C-like proteinase nsp5
Authors:	Lu, J, Khan, M.B, Young, H.S, Lemieux, M.J.
Deposit date:	2022-09-16
Release date:	2023-05-03
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	SARS-CoV-2 M pro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals. Acs Cent.Sci., 9, 2023

4JCT

ClpP2 from Listeria monocytogenes
Descriptor:	ATP-dependent Clp protease proteolytic subunit
Authors:	Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
Deposit date:	2013-02-22
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proc.Natl.Acad.Sci.USA, 110, 2013

4JCQ

ClpP1 from Listeria monocytogenes
Descriptor:	ATP-dependent Clp protease proteolytic subunit
Authors:	Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
Deposit date:	2013-02-22
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proc.Natl.Acad.Sci.USA, 110, 2013

4JCR

ClpP1 N165D mutant from Listeria monocytogenes
Descriptor:	ATP-dependent Clp protease proteolytic subunit
Authors:	Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
Deposit date:	2013-02-22
Release date:	2013-06-12
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proc.Natl.Acad.Sci.USA, 110, 2013

4U6W

HsMetAP (F220M) in complex with 1-amino-2-propylpentyl]phosphonic acid
Descriptor:	COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ...
Authors:	Arya, T, Addlagatta, A.
Deposit date:	2014-07-30
Release date:	2015-03-25
Last modified:	2019-11-20
Method:	X-RAY DIFFRACTION (1.83 Å)
Cite:	Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015

4U71

HsMetAP(F309M) IN COMPLEX WITH 1- amino(cyclohexyl)methy)phosphonic acid
Descriptor:	COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ...
Authors:	Arya, T, Addlagatta, A.
Deposit date:	2014-07-30
Release date:	2015-03-25
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015

4U75

HsMetAP (F309M) in complex with Methionine
Descriptor:	COBALT (II) ION, GLYCEROL, METHIONINE, ...
Authors:	Arya, T, Addlagatta, A.
Deposit date:	2014-07-30
Release date:	2015-03-25
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (1.94 Å)
Cite:	Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015

4U6E

HsMetAP in complex with (amino(phenyl)methyl)phosphonic acid
Descriptor:	COBALT (II) ION, Methionine aminopeptidase 1, [(R)-amino(phenyl)methyl]phosphonic acid
Authors:	Arya, T, Addlagatta, A.
Deposit date:	2014-07-28
Release date:	2015-03-25
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem., 58, 2015

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