8H7G
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![BU of 8h7g by Molmil](/molmil-images/mine/8h7g) | Cryo-EM structure of the human SAGA complex | Descriptor: | Ataxin-7, STAGA complex 65 subunit gamma, Splicing factor 3B subunit 3, ... | Authors: | Huang, J, Zhang, Y. | Deposit date: | 2022-10-20 | Release date: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of human SAGA transcriptional coactivator complex. Cell Discov, 8, 2022
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5X87
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3PWR
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![BU of 3pwr by Molmil](/molmil-images/mine/3pwr) | HIV-1 Protease Mutant L76V complexed with Saquinavir | Descriptor: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, GLYCEROL, ... | Authors: | Zhang, Y, Weber, I.T. | Deposit date: | 2010-12-08 | Release date: | 2011-04-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The L76V Drug Resistance Mutation Decreases the Dimer Stability and Rate of Autoprocessing of HIV-1 Protease by Reducing Internal Hydrophobic Contacts. Biochemistry, 50, 2011
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3RY0
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![BU of 3ry0 by Molmil](/molmil-images/mine/3ry0) | Crystal structure of TomN, a 4-Oxalocrotonate Tautomerase homologue in Tomaymycin biosynthetic pathway | Descriptor: | Putative tautomerase | Authors: | Zhang, Y, Yan, W.P, Li, W.Z, Whitman, C.P. | Deposit date: | 2011-05-10 | Release date: | 2011-08-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Kinetic, Crystallographic, and Mechanistic Characterization of TomN: Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic Pathway. Biochemistry, 50, 2011
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5Y4O
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![BU of 5y4o by Molmil](/molmil-images/mine/5y4o) | Cryo-EM structure of MscS channel, YnaI | Descriptor: | Low conductance mechanosensitive channel YnaI | Authors: | Zhang, Y, Yu, J. | Deposit date: | 2017-08-04 | Release date: | 2019-03-20 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A binding-block ion selective mechanism revealed by a Na/K selective channel. Protein Cell, 9, 2018
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8HPB
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8HQB
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![BU of 8hqb by Molmil](/molmil-images/mine/8hqb) | NMR Structure of OsCIE1-Ubox | Descriptor: | U-box domain-containing protein 12 | Authors: | Zhang, Y, Yu, C.Z, Lan, W.X. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Last modified: | 2024-06-12 | Method: | SOLUTION NMR | Cite: | Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice. Nature, 629, 2024
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4PGV
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4PGS
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4PGU
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4PGW
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6C00
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8JE4
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![BU of 8je4 by Molmil](/molmil-images/mine/8je4) | Crystal structure of LimF prenyltransferase (H239G/W273T mutant) bound with the thiodiphosphate moiety of farnesyl S-thiolodiphosphate (FSPP) | Descriptor: | MAGNESIUM ION, TRIHYDROGEN THIODIPHOSPHATE, prenyltransferase, ... | Authors: | Hamada, K, Oguni, A, Zhang, Y, Satake, M, Goto, Y, Suga, H, Ogata, K, Sengoku, T. | Deposit date: | 2023-05-15 | Release date: | 2023-11-08 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Switching Prenyl Donor Specificities of Cyanobactin Prenyltransferases. J.Am.Chem.Soc., 145, 2023
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8J3V
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4RT7
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![BU of 4rt7 by Molmil](/molmil-images/mine/4rt7) | Crystal Structure of FLT3 with a small molecule inhibitor | Descriptor: | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea, Receptor-type tyrosine-protein kinase FLT3 | Authors: | Zhang, Y, Zhang, C. | Deposit date: | 2014-11-13 | Release date: | 2015-04-22 | Last modified: | 2015-06-17 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer Discov, 5, 2015
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2N78
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![BU of 2n78 by Molmil](/molmil-images/mine/2n78) | NMR structure of IF1 from Pseudomonas aeruginosa | Descriptor: | Translation initiation factor IF-1 | Authors: | Zhang, Y. | Deposit date: | 2015-09-04 | Release date: | 2016-09-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | (1)H, (13)C and (15)N resonance assignments and secondary structure analysis of translation initiation factor 1 from Pseudomonas aeruginosa. Biomol.Nmr Assign., 10, 2016
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4GA3
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![BU of 4ga3 by Molmil](/molmil-images/mine/4ga3) | Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260 | Descriptor: | 1-butyl-3-(2-hydroxy-2,2-diphosphonoethyl)-1H-imidazol-3-ium, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | Authors: | Liu, Y.-L, Zhang, Y, Oldfield, E. | Deposit date: | 2012-07-24 | Release date: | 2013-05-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis. ACS MED.CHEM.LETT., 4, 2013
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2M0G
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![BU of 2m0g by Molmil](/molmil-images/mine/2m0g) | Structure, phosphorylation and U2AF65 binding of the Nterminal Domain of splicing factor 1 during 3 splice site Recognition | Descriptor: | Splicing factor 1, Splicing factor U2AF 65 kDa subunit | Authors: | Madl, T, Sattler, M, Zhang, Y, Bagdiul, I, Kern, T, Kang, H, Zou, P, Maeusbacher, N, Sieber, S.A, Kraemer, A. | Deposit date: | 2012-10-25 | Release date: | 2013-01-30 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. Nucleic Acids Res., 41, 2013
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4HS4
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![BU of 4hs4 by Molmil](/molmil-images/mine/4hs4) | Crystal structure of a putative chromate reductase from Gluconacetobacter hansenii, Gh-ChrR, containing a Y129N substitution. | Descriptor: | Chromate reductase, FLAVIN MONONUCLEOTIDE | Authors: | Zhang, Y, Robinson, H, Buchko, G.W. | Deposit date: | 2012-10-29 | Release date: | 2012-12-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mechanistic insights of chromate and uranyl reduction by the NADPH-dependent FMN reductase, ChrR, from Gluconacetobacter hansenii To be Published
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2M09
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![BU of 2m09 by Molmil](/molmil-images/mine/2m09) | Structure, phosphorylation and U2AF65 binding of the Nterminal Domain of splicing factor 1 during 3 splice site Recognition | Descriptor: | Splicing factor 1 | Authors: | Madl, T, Sattler, M, Zhang, Y, Bagdiul, I, Kern, T, Kang, H, Zou, P, Maeusbacher, N, Sieber, S.A, Kraemer, A. | Deposit date: | 2012-10-22 | Release date: | 2013-01-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. Nucleic Acids Res., 41, 2013
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7DTK
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4H6P
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![BU of 4h6p by Molmil](/molmil-images/mine/4h6p) | Crystal structure of a putative chromate reductase from Gluconacetobacter hansenii, Gh-ChrR, containing a R101A substitution. | Descriptor: | Chromate reductase, FLAVIN MONONUCLEOTIDE | Authors: | Zhang, Y, Robinson, H, Buchko, G.W. | Deposit date: | 2012-09-19 | Release date: | 2012-10-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.556 Å) | Cite: | Mechanistic insights of chromate and uranyl reduction by the NADPH-dependent FMN reductase, ChrR, from Gluconacetobacter hansenii To be Published
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2Q5A
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![BU of 2q5a by Molmil](/molmil-images/mine/2q5a) | human Pin1 bound to L-PEPTIDE | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE, Five residue peptide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Authors: | Noel, J.P, Zhang, Y. | Deposit date: | 2007-05-31 | Release date: | 2007-06-26 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis for high-affinity peptide inhibition of human Pin1. Acs Chem.Biol., 2, 2007
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2QCX
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![BU of 2qcx by Molmil](/molmil-images/mine/2qcx) | Crystal structure of Bacillus subtilis TenA Y112F mutant complexed with formyl aminomethyl pyrimidine | Descriptor: | N-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-N-(2-HYDROXYETHYL)FORMAMIDE, Transcriptional activator tenA | Authors: | Zhang, Y, Jenkins, A.L, Begley, T.P, Ealick, S.E. | Deposit date: | 2007-06-19 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mutagenesis studies on TenA: A thiamin salvage enzyme from Bacillus subtilis Bioorg.Chem., 36, 2008
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4IA9
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![BU of 4ia9 by Molmil](/molmil-images/mine/4ia9) | Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide | Descriptor: | 1,2-ETHANEDIOL, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... | Authors: | Dong, A, Dombrovski, L, Bolshan, Y, Getlik, M, Tempel, W, Kuznetsova, E, Wasney, G.A, Hajian, T, Poda, G, Nguyen, K.T, Schapira, M, Brown, P.J, Al-awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Smil, D, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-12-06 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett, 4, 2013
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