8PFP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pfp by Molmil](/molmil-images/mine/8pfp) | |
8PFL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pfl by Molmil](/molmil-images/mine/8pfl) | Crystal structure of WRN helicase domain in complex with 3 | Descriptor: | 2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-7-oxidanylidene-6-[4-(3-oxidanylpyridin-2-yl)carbonylpiperazin-1-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]-~{N}-[2-methyl-4-(trifluoromethyl)phenyl]ethanamide, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION | Authors: | Scheufler, C, Meyer, M, Moebitz, H. | Deposit date: | 2023-06-16 | Release date: | 2024-04-24 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature, 629, 2024
|
|
8PFO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pfo by Molmil](/molmil-images/mine/8pfo) | Crystal structure of WRN helicase domain in complex with HRO761 | Descriptor: | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION, ~{N}-[2-chloranyl-4-(trifluoromethyl)phenyl]-2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-6-[4-(6-methyl-5-oxidanyl-pyrimidin-4-yl)carbonylpiperazin-1-yl]-7-oxidanylidene-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]ethanamide | Authors: | Scheufler, C, Meyer, M, Moebitz, H. | Deposit date: | 2023-06-16 | Release date: | 2024-04-24 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. Nature, 629, 2024
|
|
4YN2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yn2 by Molmil](/molmil-images/mine/4yn2) | THE ATOMIC STRUCTURE OF WISEANA SPP ENTOMOPOXVIRUS (WSEPV) FUSOLIN SPINDLES | Descriptor: | 1,2-ETHANEDIOL, FUSOLIN, ZINC ION, ... | Authors: | Chiu, E, Bunker, R.D, Metcalf, P. | Deposit date: | 2015-03-09 | Release date: | 2015-04-08 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4YN1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yn1 by Molmil](/molmil-images/mine/4yn1) | THE ATOMIC STRUCTURE OF ANOMALA CUPREA ENTOMOPOXVIRUS (ACEPV) FUSOLIN SPINDLES | Descriptor: | 1,2-ETHANEDIOL, Fusolin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Chiu, E, Bunker, R.D, Metcalf, P. | Deposit date: | 2015-03-09 | Release date: | 2015-04-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
2R1R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2r1r by Molmil](/molmil-images/mine/2r1r) | |
6YHF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yhf by Molmil](/molmil-images/mine/6yhf) | Solution NMR Structure of APP TMD | Descriptor: | Amyloid-beta precursor protein | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-29 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
|
|
6YHO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yho by Molmil](/molmil-images/mine/6yho) | Solution NMR Structure of APP G38P mutant TM | Descriptor: | Amyloid-beta precursor protein G38P mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
|
|
6YHP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yhp by Molmil](/molmil-images/mine/6yhp) | Solution NMR Structure of APP V44M mutant TMD | Descriptor: | Amyloid-beta precursor protein V44M mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
|
|
6YHX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yhx by Molmil](/molmil-images/mine/6yhx) | Solution NMR Structure of APP I45T mutant TMD | Descriptor: | Amyloid-beta precursor protein I45T mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-31 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
|
|
6YHI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yhi by Molmil](/molmil-images/mine/6yhi) | Solution NMR Structure of APP G38L mutant TMD | Descriptor: | Amyloid-beta precursor protein G38L mutant | Authors: | Silber, M, Muhle-Goll, C. | Deposit date: | 2020-03-30 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
|
|
2BXJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bxj by Molmil](/molmil-images/mine/2bxj) | Double Mutant of the Ribosomal Protein S6 | Descriptor: | 30S RIBOSOMAL PROTEIN S6 | Authors: | Otzen, D.E. | Deposit date: | 2005-07-26 | Release date: | 2005-10-26 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Antagonism, Non-Native Interactions and Non-Two-State Folding in S6 Revealed by Double-Mutant Cycle Analysis. Protein Eng.Des.Sel., 18, 2005
|
|
6Z9I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6z9i by Molmil](/molmil-images/mine/6z9i) | Escherichia coli D-2-deoxyribose-5-phosphate aldolase - N21K mutant complex with reaction products | Descriptor: | 1,2-ETHANEDIOL, Deoxyribose-phosphate aldolase, GLYCERALDEHYDE-3-PHOSPHATE, ... | Authors: | Paakkonen, J, Hakulinen, N, Rouvinen, J. | Deposit date: | 2020-06-04 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods. Appl.Microbiol.Biotechnol., 104, 2020
|
|
6Z9J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6z9j by Molmil](/molmil-images/mine/6z9j) | |
6Z9H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6z9h by Molmil](/molmil-images/mine/6z9h) | Escherichia coli D-2-deoxyribose-5-phosphate aldolase - C47V/G204A/S239D mutant | Descriptor: | 1,2-ETHANEDIOL, Deoxyribose-phosphate aldolase, FORMIC ACID, ... | Authors: | Paakkonen, J, Hakulinen, N, Rouvinen, J. | Deposit date: | 2020-06-04 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods. Appl.Microbiol.Biotechnol., 104, 2020
|
|
7ZAK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zak by Molmil](/molmil-images/mine/7zak) | Crystal structure of HLA-DP (DPA1*02:01-DPB1*01:01) in complex with a peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, MAGNESIUM ION, ... | Authors: | Racle, J, Guillaume, P, Larabi, A, Lau, K, Pojer, F, Gfeller, D. | Deposit date: | 2022-03-22 | Release date: | 2023-03-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes. Immunity, 56, 2023
|
|
7ZFR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zfr by Molmil](/molmil-images/mine/7zfr) | Crystal structure of HLA-DP (DPA1*02:01-DPB1*01:01) in complex with a peptide bound in the reverse direction | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DP alpha chain (DPA1*02:01), MHC class II HLA-DP beta chain (DPB1*01:01), ... | Authors: | Racle, J, Guillaume, P, Larabi, A, Lau, K, Pojer, F, Gfeller, D. | Deposit date: | 2022-04-01 | Release date: | 2023-04-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes. Immunity, 56, 2023
|
|
7PZR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7pzr by Molmil](/molmil-images/mine/7pzr) | Cryo-EM structure of POLRMT in free form. | Descriptor: | DNA-directed RNA polymerase, mitochondrial | Authors: | Das, H, Hallberg, B.M. | Deposit date: | 2021-10-13 | Release date: | 2022-11-16 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization. Cell, 185, 2022
|
|
5WDT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5wdt by Molmil](/molmil-images/mine/5wdt) | 70S ribosome-EF-Tu H84A complex with GppNHp | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Fislage, M, Brown, Z, Frank, J. | Deposit date: | 2017-07-06 | Release date: | 2018-04-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A. Nucleic Acids Res., 46, 2018
|
|
5WE6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5we6 by Molmil](/molmil-images/mine/5we6) | 70S ribosome-EF-Tu H84A complex with GTP and cognate tRNA | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Fislage, M, Frank, J. | Deposit date: | 2017-07-07 | Release date: | 2018-04-25 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A. Nucleic Acids Res., 46, 2018
|
|
7PZP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7pzp by Molmil](/molmil-images/mine/7pzp) | |
5WE4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5we4 by Molmil](/molmil-images/mine/5we4) | 70S ribosome-EF-Tu wt complex with GppNHp | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Fislage, M, Brown, Z, Frank, J. | Deposit date: | 2017-07-07 | Release date: | 2018-04-25 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A. Nucleic Acids Res., 46, 2018
|
|
7QLI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qli by Molmil](/molmil-images/mine/7qli) | Cis structure of rsKiiro at 290 K | Descriptor: | GLYCEROL, SULFATE ION, rsKiiro | Authors: | van Thor, J.J, Baxter, J.M. | Deposit date: | 2021-12-20 | Release date: | 2023-07-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.155 Å) | Cite: | Optical control of ultrafast structural dynamics in a fluorescent protein. Nat.Chem., 15, 2023
|
|
7QLK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qlk by Molmil](/molmil-images/mine/7qlk) | |
7QLL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qll by Molmil](/molmil-images/mine/7qll) | |