3UQG
 
 | | c-SRC kinase domain in complex with bumpless BKI analog UW1243 | | Descriptor: | 1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src | | Authors: | Merritt, E.A, Larson, E.T. | | Deposit date: | 2011-11-20 | | Release date: | 2012-03-14 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.
J.Med.Chem., 55, 2012
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3V5T
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6BFA
 | | Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1553 | | Descriptor: | 1-{4-amino-3-[6-(cyclopropyloxy)naphthalen-2-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1 | | Authors: | Merritt, E.A. | | Deposit date: | 2017-10-26 | | Release date: | 2017-12-06 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
J. Med. Chem., 59, 2016
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4Y5Q
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3UPZ
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3UQF
 | | c-SRC kinase domain in complex with BKI RM-1-89 | | Descriptor: | 3-(6-ethoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src | | Authors: | Merritt, E.A, Larson, E.T. | | Deposit date: | 2011-11-20 | | Release date: | 2012-03-14 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.
J.Med.Chem., 55, 2012
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3UPX
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3V51
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3V5P
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6TYD
 | | Structure of human LDB1 in complex with SSBP2 | | Descriptor: | LIM domain-binding protein 1, Single-stranded DNA-binding protein 2 | | Authors: | Wang, H, Wang, Z, Xu, W. | | Deposit date: | 2019-08-08 | | Release date: | 2020-01-01 | | Last modified: | 2020-01-29 | | Method: | X-RAY DIFFRACTION (2.803 Å) | | Cite: | Crystal structure of human LDB1 in complex with SSBP2.
Proc.Natl.Acad.Sci.USA, 117, 2020
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2GJL
 | | Crystal Structure of 2-nitropropane dioxygenase | | Descriptor: | FLAVIN MONONUCLEOTIDE, hypothetical protein PA1024 | | Authors: | Suh, S.W. | | Deposit date: | 2006-03-31 | | Release date: | 2006-05-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of 2-Nitropropane Dioxygenase Complexed with FMN and Substrate: identification of the catalytic base
J.Biol.Chem., 281, 2006
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2GJN
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8P83
 | | Cryo-EM structure of full-length human UBR5 (homotetramer) | | Descriptor: | E3 ubiquitin-protein ligase UBR5 | | Authors: | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | | Deposit date: | 2023-05-31 | | Release date: | 2023-06-14 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.87 Å) | | Cite: | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Mol.Cell, 83, 2023
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4R1N
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7XL9
 | | The structure of HucR with urate | | Descriptor: | CHLORIDE ION, Transcriptional regulator, MarR family, ... | | Authors: | Park, S.Y. | | Deposit date: | 2022-04-21 | | Release date: | 2022-07-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | The structure of Deinococcus radiodurans transcriptional regulator HucR retold with the urate bound.
Biochem.Biophys.Res.Commun., 615, 2022
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6WIN
 | | Type 6 secretion amidase effector 2 (Tae2) | | Descriptor: | Type 6 secretion amidase effector 2 | | Authors: | Chou, S, Radkov, A.D. | | Deposit date: | 2020-04-10 | | Release date: | 2020-04-22 | | Last modified: | 2021-05-05 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin.
Cell, 183, 2020
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5UIX
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5WW0
 | | Crystal structure of Set7, a novel histone methyltransferase in Schizossacharomyces pombe | | Descriptor: | SET domain-containing protein 7, SULFATE ION | | Authors: | Mevius, D.E.H.F, Shen, Y, Morishita, M, Carrozzini, B, Caliandro, R, di Luccio, E. | | Deposit date: | 2016-12-30 | | Release date: | 2017-12-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Set7 Is a H3K37 Methyltransferase in Schizosaccharomyces pombe and Is Required for Proper Gametogenesis.
Structure, 27, 2019
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3RUI
 | | Crystal structure of Atg7C-Atg8 complex | | Descriptor: | Autophagy-related protein 8, Ubiquitin-like modifier-activating enzyme ATG7, ZINC ION | | Authors: | Hong, S.B, Kim, B.W, Song, H.K. | | Deposit date: | 2011-05-05 | | Release date: | 2011-11-23 | | Last modified: | 2013-07-03 | | Method: | X-RAY DIFFRACTION (1.906 Å) | | Cite: | Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8.
Nat.Struct.Mol.Biol., 18, 2011
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3RUJ
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8TH4
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8TH3
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5V7U
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7W3D
 | | Crystal structure of BRD4 bromodomain 1 (BD1) in complex with N2-(1,2,3-benzotriazol-5-yl)-N3-(dimethylsulfamoyl)-N6-[(2S)-1-methoxypropan-2-yl]pyridine-2,3,6-triamine | | Descriptor: | Bromodomain-containing protein 4, N2-(1,2,3-benzotriazol-5-yl)-N3-(dimethylsulfamoyl)-N6-[(2S)-1-methoxypropan-2-yl]pyridine-2,3,6-triamine | | Authors: | Park, T.H, Lee, B.I. | | Deposit date: | 2021-11-25 | | Release date: | 2022-09-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Discovery of BET specific bromodomain inhibitors with a novel scaffold.
Bioorg.Med.Chem., 72, 2022
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5H6Z
 | | Crystal structure of Set7, a novel histone methyltransferase in Schizossacharomyces pombe | | Descriptor: | AMMONIUM ION, DI(HYDROXYETHYL)ETHER, SET domain-containing protein 7, ... | | Authors: | Mevius, D.E.H.F, Shen, Y, Morishita, M, Carrozzini, B, Caliandro, R, di Luccio, E. | | Deposit date: | 2016-11-15 | | Release date: | 2017-11-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Set7 Is a H3K37 Methyltransferase in Schizosaccharomyces pombe and Is Required for Proper Gametogenesis.
Structure, 27, 2019
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