4QF1
Crystal structure of unliganded CH59UA, the inferred unmutated ancestor of the RV144 anti-HIV antibody lineage producing CH59
Summary for 4QF1
Entry DOI | 10.2210/pdb4qf1/pdb |
Related | 4HPY |
Descriptor | CH59UA Fab fragment of heavy chain, Inferred unmutated ancestor (UA) of anti-HIV antibody CH59, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total) |
Functional Keywords | anti-hiv antibody, gp120, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 94824.29 |
Authors | Wiehe, K.,Easterhoff, D.,Luo, K.,Nicely, N.I.,Bradley, T.,Jaeger, F.H.,Dennison, S.M.,Zhang, R.,Lloyd, K.E.,Stolarchuk, C.,Parks, R.,Sutherland, L.L.,Scearce, R.M.,Morris, L.,Kaewkungwal, J.,Nitayaphan, S.,Pitisuttithum, P.,Rerks-Ngarm, S.,Michael, N.,Kim, J.,Kelsoe, G.,Montefiori, D.C.,Tomaras, G.,Bonsignori, M.,Santra, S.,Kepler, T.B.,Alam, S.M.,Moody, M.A.,Liao, H.-X.,Haynes, B.F. (deposition date: 2014-05-19, release date: 2015-02-18, Last modification date: 2024-04-03) |
Primary citation | Wiehe, K.,Easterhoff, D.,Luo, K.,Nicely, N.I.,Bradley, T.,Jaeger, F.H.,Dennison, S.M.,Zhang, R.,Lloyd, K.E.,Stolarchuk, C.,Parks, R.,Sutherland, L.L.,Scearce, R.M.,Morris, L.,Kaewkungwal, J.,Nitayaphan, S.,Pitisuttithum, P.,Rerks-Ngarm, S.,Sinangil, F.,Phogat, S.,Michael, N.L.,Kim, J.H.,Kelsoe, G.,Montefiori, D.C.,Tomaras, G.D.,Bonsignori, M.,Santra, S.,Kepler, T.B.,Alam, S.M.,Moody, M.A.,Liao, H.X.,Haynes, B.F. Antibody Light-Chain-Restricted Recognition of the Site of Immune Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved. Immunity, 41:909-918, 2014 Cited by PubMed: 25526306DOI: 10.1016/j.immuni.2014.11.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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