4QF1

Crystal structure of unliganded CH59UA, the inferred unmutated ancestor of the RV144 anti-HIV antibody lineage producing CH59

Summary for 4QF1

• Entry DOI: 10.2210/pdb4qf1/pdb
• Related: 4HPY
• Descriptor: CH59UA Fab fragment of heavy chain, Inferred unmutated ancestor (UA) of anti-HIV antibody CH59, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total)
• Functional Keywords: anti-hiv antibody, gp120, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 94824.29

Authors

Wiehe, K.,Easterhoff, D.,Luo, K.,Nicely, N.I.,Bradley, T.,Jaeger, F.H.,Dennison, S.M.,Zhang, R.,Lloyd, K.E.,Stolarchuk, C.,Parks, R.,Sutherland, L.L.,Scearce, R.M.,Morris, L.,Kaewkungwal, J.,Nitayaphan, S.,Pitisuttithum, P.,Rerks-Ngarm, S.,Michael, N.,Kim, J.,Kelsoe, G.,Montefiori, D.C.,Tomaras, G.,Bonsignori, M.,Santra, S.,Kepler, T.B.,Alam, S.M.,Moody, M.A.,Liao, H.-X.,Haynes, B.F. (deposition date: 2014-05-19, release date: 2015-02-18, Last modification date: 2024-04-03)

• Primary citation: Wiehe, K.,Easterhoff, D.,Luo, K.,Nicely, N.I.,Bradley, T.,Jaeger, F.H.,Dennison, S.M.,Zhang, R.,Lloyd, K.E.,Stolarchuk, C.,Parks, R.,Sutherland, L.L.,Scearce, R.M.,Morris, L.,Kaewkungwal, J.,Nitayaphan, S.,Pitisuttithum, P.,Rerks-Ngarm, S.,Sinangil, F.,Phogat, S.,Michael, N.L.,Kim, J.H.,Kelsoe, G.,Montefiori, D.C.,Tomaras, G.D.,Bonsignori, M.,Santra, S.,Kepler, T.B.,Alam, S.M.,Moody, M.A.,Liao, H.X.,Haynes, B.F.; Antibody Light-Chain-Restricted Recognition of the Site of Immune Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved.; Immunity, 41:909-918, 2014; PubMed: 25526306; DOI: 10.1016/j.immuni.2014.11.014

Experimental method

X-RAY DIFFRACTION (2.4 Å)