4QF1

Crystal structure of unliganded CH59UA, the inferred unmutated ancestor of the RV144 anti-HIV antibody lineage producing CH59

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (H, A)	CH59UA Fab fragment of heavy chain	polymer	225	23958.8	2		Homo sapiens
2	B, D (L, B)	Inferred unmutated ancestor (UA) of anti-HIV antibody CH59	polymer	214	22878.3	2		Homo sapiens
3	E, I (H, A)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
4	F, K (L, B)	TRIETHYLENE GLYCOL	non-polymer		150.2	2	Chemie (PGE)
5	G, L (L, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	H, J (A, B)	TETRAETHYLENE GLYCOL	non-polymer		194.2	2	Chemie (PG4)
7	M, N, O, P (H, L, A, B)	water	water		18.0	201	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	93674.1
Non-Polymers*	Number of molecules	8
	Total formula weight	1150.2
All*	Total formula weight	94824.3

*Water molecules are not included.