1RJ5
 
 | | Crystal Structure of the Extracellular Domain of Murine Carbonic Anhydrase XIV | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, CHLORIDE ION, ... | | Authors: | Whittington, D.A, Grubb, J.H, Waheed, A, Shah, G.N, Sly, W.S, Christianson, D.W. | | Deposit date: | 2003-11-18 | | Release date: | 2004-03-09 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.
J.Biol.Chem., 279, 2004
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3O3X
 | | Crystal structure of gp41-5, a single-chain 5-helix-bundle based on HIV gp41 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ISOPROPYL ALCOHOL, gp41-5 | | Authors: | Horne, W.S, Johnson, L.M, Gellman, S.H. | | Deposit date: | 2010-07-26 | | Release date: | 2011-07-27 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Broad Distribution of Energetically Important Contacts across an Extended Protein Interface.
J.Am.Chem.Soc., 133, 2011
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1U9G
 | | Heterocyclic Peptide Backbone Modification in GCN4-pLI Based Coiled Coils: Replacement of K(8)L(9) | | Descriptor: | General control protein GCN4, SULFATE ION | | Authors: | Horne, W.S, Yadav, M.K, Stout, C.D, Ghadiri, M.R. | | Deposit date: | 2004-08-09 | | Release date: | 2004-11-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Heterocyclic peptide backbone modifications in an alpha-helical coiled coil.
J.Am.Chem.Soc., 126, 2004
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1U9H
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3O3Y
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3OY3
 | | Crystal structure of ABL T315I mutant kinase domain bound with a DFG-out inhibitor AP24589 | | Descriptor: | 5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1H-imidazole-2-carboxamide, Tyrosine-protein kinase ABL1 | | Authors: | Zhou, T, Commodore, L, Huang, W.S, Wang, Y, Thomas, M, Keats, J, Xu, Q, Rivera, V, Shakespeare, W.C, Clackson, T, Dalgarno, D.C, Zhu, X. | | Deposit date: | 2010-09-22 | | Release date: | 2010-12-15 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance.
Chem.Biol.Drug Des., 77, 2011
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1PU9
 | | Crystal Structure of Tetrahymena GCN5 with Bound Coenzyme A and a 19-residue Histone H3 Peptide | | Descriptor: | COENZYME A, HAT A1, Histone H3 | | Authors: | Clements, A, Poux, A.N, Lo, W.S, Pillus, L, Berger, S.L, Marmorstein, R. | | Deposit date: | 2003-06-24 | | Release date: | 2003-09-23 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for histone and phospho-histone binding by the GCN5 histone acetyltransferase
Mol.Cell, 12, 2003
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3NIJ
 | | The structure of UBR box (HIAA) | | Descriptor: | E3 ubiquitin-protein ligase UBR1, Peptide HIAA, ZINC ION | | Authors: | Choi, W.S, Jeong, B.-C, Lee, M.-R, Song, H.K. | | Deposit date: | 2010-06-16 | | Release date: | 2010-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
Nat.Struct.Mol.Biol., 17, 2010
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3NIN
 | | The structure of UBR box (RLGES) | | Descriptor: | E3 ubiquitin-protein ligase UBR1, Peptide RLGES, ZINC ION | | Authors: | Choi, W.S, Jeong, B.-C, Lee, M.-R, Song, H.K. | | Deposit date: | 2010-06-16 | | Release date: | 2010-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
Nat.Struct.Mol.Biol., 17, 2010
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3NIT
 | | The structure of UBR box (native1) | | Descriptor: | E3 ubiquitin-protein ligase UBR1, ZINC ION | | Authors: | Choi, W.S, Jeong, B.-C, Lee, M.-R, Song, H.K. | | Deposit date: | 2010-06-16 | | Release date: | 2010-09-15 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
Nat.Struct.Mol.Biol., 17, 2010
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3OXZ
 | | Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534 | | Descriptor: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Tyrosine-protein kinase ABL1 | | Authors: | Zhou, T, Huang, W.S, Wang, Y, Thomas, M, Keats, J, Xu, Q, Rivera, V, Shakespeare, W.C, Clackson, T, Dalgarno, D.C, Zhu, X. | | Deposit date: | 2010-09-22 | | Release date: | 2010-12-15 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance.
Chem.Biol.Drug Des., 77, 2011
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1U8B
 | | Crystal structure of the methylated N-ADA/DNA complex | | Descriptor: | 5'-D(*AP*AP*TP*CP*TP*TP*GP*CP*GP*CP*TP*TP*T)-3', 5'-D(*TP*AP*AP*AP*TP*T)-3', 5'-D(P*AP*AP*AP*GP*CP*GP*CP*AP*AP*GP*AP*T)-3', ... | | Authors: | He, C, Hus, J.-C, Sun, L.J, Zhou, P, Norman, D.P.G, Dotsch, V, Gross, J.D, Lane, W.S, Wagner, G, Verdine, G.L. | | Deposit date: | 2004-08-05 | | Release date: | 2005-10-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.
Mol.Cell, 20, 2005
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1PUA
 | | Crystal Structure of Tetrahymena GCN5 with Bound Coenzyme A and a Phosphorylated, 19-residue Histone H3 peptide | | Descriptor: | COENZYME A, HAT A1, Histone H3 | | Authors: | Clements, A, Poux, A.N, Lo, W.S, Pillus, L, Berger, S.L, Marmorstein, R. | | Deposit date: | 2003-06-24 | | Release date: | 2003-09-23 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for histone and phospho-histone binding by the GCN5 histone acetyltransferase
Mol.Cell, 12, 2003
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3NIL
 | | The structure of UBR box (RDAA) | | Descriptor: | ACETATE ION, E3 ubiquitin-protein ligase UBR1, Peptide RDAA, ... | | Authors: | Choi, W.S, Jeong, B.-C, Lee, M.-R, Song, H.K. | | Deposit date: | 2010-06-16 | | Release date: | 2010-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
Nat.Struct.Mol.Biol., 17, 2010
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3NIK
 | | The structure of UBR box (REAA) | | Descriptor: | E3 ubiquitin-protein ligase UBR1, Peptide REAA, ZINC ION | | Authors: | Choi, W.S, Jeong, B.-C, Lee, M.-R, Song, H.K. | | Deposit date: | 2010-06-16 | | Release date: | 2010-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
Nat.Struct.Mol.Biol., 17, 2010
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3NIS
 | | The structure of UBR box (native2) | | Descriptor: | ACETATE ION, E3 ubiquitin-protein ligase UBR1, ZINC ION | | Authors: | Choi, W.S, Jeong, B.-C, Lee, M.-R, Song, H.K. | | Deposit date: | 2010-06-16 | | Release date: | 2010-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
Nat.Struct.Mol.Biol., 17, 2010
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1NY3
 | | Crystal structure of ADP bound to MAP KAP kinase 2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAP kinase-activated protein kinase 2 | | Authors: | Underwood, K.W, Parris, K.D, Federico, E, Mosyak, L, Shane, T, Taylor, M, Svenson, K, Liu, Y, Hsiao, C.L, Wolfrom, S, Maguire, M, Malakian, K, Telliez, J.B, Lin, L.L, Kriz, R.W, Seehra, J, Somers, W.S, Stahl, M.L. | | Deposit date: | 2003-02-11 | | Release date: | 2003-10-14 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme
Structure, 11, 2003
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1RJ6
 | | Crystal Structure of the Extracellular Domain of Murine Carbonic Anhydrase XIV in Complex with Acetazolamide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase XIV, ... | | Authors: | Whittington, D.A, Grubb, J.H, Waheed, A, Shah, G.N, Sly, W.S, Christianson, D.W. | | Deposit date: | 2003-11-18 | | Release date: | 2004-03-09 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.
J.Biol.Chem., 279, 2004
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1NXK
 | | Crystal structure of staurosporine bound to MAP KAP kinase 2 | | Descriptor: | MAP kinase-activated protein kinase 2, STAUROSPORINE, SULFATE ION | | Authors: | Underwood, K.W, Parris, K.D, Federico, E, Mosyak, L, Czerwinski, R.M, Shane, T, Taylor, M, Svenson, K, Liu, Y, Hsiao, C.L, Wolfrom, S, Malakian, K, Telliez, J.B, Lin, L.L, Kriz, R.W, Seehra, J, Somers, W.S, Stahl, M.L. | | Deposit date: | 2003-02-10 | | Release date: | 2003-10-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme
Structure, 11, 2003
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1Q6O
 | | Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-gulonaet 6-phosphate | | Descriptor: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-GULURONIC ACID 6-PHOSPHATE, MAGNESIUM ION | | Authors: | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | | Deposit date: | 2003-08-13 | | Release date: | 2003-10-28 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.202 Å) | | Cite: | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily
Biochemistry, 42, 2003
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1Q6R
 | | Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-xylulose 5-phosphate | | Descriptor: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-XYLULOSE 5-PHOSPHATE, MAGNESIUM ION | | Authors: | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | | Deposit date: | 2003-08-13 | | Release date: | 2003-10-28 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily
Biochemistry, 42, 2003
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3NIH
 | | The structure of UBR box (RIAAA) | | Descriptor: | E3 ubiquitin-protein ligase UBR1, Peptide RIAAA, ZINC ION | | Authors: | Choi, W.S, Jeong, B.-C, Lee, M.-R, Song, H.K. | | Deposit date: | 2010-06-16 | | Release date: | 2010-09-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases
Nat.Struct.Mol.Biol., 17, 2010
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1Q6L
 | | Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate | | Descriptor: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-THREONOHYDROXAMATE 4-PHOSPHATE, MAGNESIUM ION | | Authors: | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | | Deposit date: | 2003-08-13 | | Release date: | 2003-10-28 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily
Biochemistry, 42, 2003
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1Q6Q
 | | Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound xylitol 5-phosphate | | Descriptor: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-XYLITOL 5-PHOSPHATE, MAGNESIUM ION | | Authors: | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | | Deposit date: | 2003-08-13 | | Release date: | 2003-10-28 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (1.695 Å) | | Cite: | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily
Biochemistry, 42, 2003
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1U9F
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