Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
5X35
DownloadVisualize
BU of 5x35 by Molmil
Solution structure of the Family 1 carbohydrate-binding module with mannosylated Thr1
Descriptor: Exoglucanase 1, alpha-D-mannopyranose
Authors:Feng, Y, Tan, Z.
Deposit date:2017-02-04
Release date:2017-05-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Insight into the Stabilizing Effect of O-Glycosylation
Biochemistry, 56, 2017
5X34
DownloadVisualize
BU of 5x34 by Molmil
Solution structure of the Family 1 carbohydrate-binding module, unglycosylated form
Descriptor: Exoglucanase 1
Authors:Feng, Y, Tan, Z.
Deposit date:2017-02-04
Release date:2017-05-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Insight into the Stabilizing Effect of O-Glycosylation
Biochemistry, 56, 2017
5X39
DownloadVisualize
BU of 5x39 by Molmil
Solution structure of the Family 1 carbohydrate-binding module Q2A mutant with mannosylated Ser3
Descriptor: Exoglucanase 1, alpha-D-mannopyranose
Authors:Feng, Y, Tan, Z.
Deposit date:2017-02-04
Release date:2017-05-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Insight into the Stabilizing Effect of O-Glycosylation
Biochemistry, 56, 2017
5X37
DownloadVisualize
BU of 5x37 by Molmil
Solution structure of the Family 1 carbohydrate-binding module with mannosylated Ser14
Descriptor: Exoglucanase 1, alpha-D-mannopyranose
Authors:Feng, Y, Tan, Z.
Deposit date:2017-02-04
Release date:2017-05-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Insight into the Stabilizing Effect of O-Glycosylation
Biochemistry, 56, 2017
6XAE
DownloadVisualize
BU of 6xae by Molmil
SUBSTITUTED BENZYLOXYTRICYCLIC COMPOUNDS AS RETINOIC ACID-RELATED ORPHAN RECEPTOR GAMMA T AGONISTS
Descriptor: Nuclear receptor ROR-gamma, trans-4-{(3aR,9bR)-7-[(2-chloro-6-fluorophenyl)methoxy]-9b-[(4-fluorophenyl)sulfonyl]-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonyl}cyclohexane-1-carboxylic acid
Authors:Sack, J.S.
Deposit date:2020-06-04
Release date:2020-06-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.257 Å)
Cite:Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (ROR gamma t) agonists.
Bioorg.Med.Chem.Lett., 30, 2020
4FI9
DownloadVisualize
BU of 4fi9 by Molmil
Structure of human SUN-KASH complex
Descriptor: Nesprin-2, SUN domain-containing protein 2
Authors:Wang, W.J, Shi, Z.B.
Deposit date:2012-06-08
Release date:2012-07-18
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural insights into SUN-KASH complexes across the nuclear envelope.
Cell Res., 22, 2012
4FIH
DownloadVisualize
BU of 4fih by Molmil
Catalytic domain of human PAK4 with QKFTGLPRQW peptide
Descriptor: Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FIJ
DownloadVisualize
BU of 4fij by Molmil
Catalytic domain of human PAK4
Descriptor: Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FIE
DownloadVisualize
BU of 4fie by Molmil
Full-length human PAK4
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FIG
DownloadVisualize
BU of 4fig by Molmil
Catalytic domain of human PAK4
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase PAK 4
Authors:Ha, B.H, Boggon, T.J.
Deposit date:2012-06-08
Release date:2012-09-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc.Natl.Acad.Sci.USA, 109, 2012
8WMN
DownloadVisualize
BU of 8wmn by Molmil
Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (symmetric 20-nt complementary)
Descriptor: DNA (62-MER), MAGNESIUM ION, PcrIIC1, ...
Authors:Zhang, S, Lin, S, Liu, J.J.G.
Deposit date:2023-10-04
Release date:2024-06-05
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 2024
8WMM
DownloadVisualize
BU of 8wmm by Molmil
Structure of CbCas9-PcrIIC1 complex bound to 28-bp DNA substrate (20-nt complementary)
Descriptor: MAGNESIUM ION, NTS, PcrIIC1, ...
Authors:Zhang, S, Lin, S, Liu, J.J.G.
Deposit date:2023-10-04
Release date:2024-06-05
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 2024
8WMH
DownloadVisualize
BU of 8wmh by Molmil
Structure of CbCas9 bound to 6-nucleotide complementary DNA substrate
Descriptor: NTS, TS, deadCbCas9, ...
Authors:Zhang, S, Lin, S, Liu, J.J.G.
Deposit date:2023-10-03
Release date:2024-06-05
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 2024
8WR4
DownloadVisualize
BU of 8wr4 by Molmil
Structure of CbCas9-PcrIIC1 complex bound to 62-bp DNA substrate (non-targeting complex)
Descriptor: CbCas9 effector-1, DNA (62-MER), MAGNESIUM ION, ...
Authors:Zhang, S, Lin, S, Liu, J.J.G.
Deposit date:2023-10-13
Release date:2024-06-05
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity.
Nature, 2024
6VBK
DownloadVisualize
BU of 6vbk by Molmil
Crystal structure of N-terminal domain of Mycobacterium tuberculosis complex Lon protease
Descriptor: GLYCEROL, Lon211
Authors:Bi, F.K, Chen, C, Chen, X.Y, Guo, C.Y, Lin, D.H.
Deposit date:2019-12-19
Release date:2020-12-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the N domain of Lon protease from Mycobacterium avium complex.
Protein Sci., 28, 2019
6NSL
DownloadVisualize
BU of 6nsl by Molmil
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound-6c AKA 6-((1-(4-CYANOPHENY L)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL)AMINO)-N-CYCLOPROPYL-8-(M ETHYLAMINO)IMIDAZO[1,2-B]PYRIDAZINE-3-CARBOXAMIDE
Descriptor: 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-N-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2, SULFATE ION
Authors:Muckelbauer, J.M, Khan, J.A.
Deposit date:2019-01-25
Release date:2020-01-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
Acs Med.Chem.Lett., 10, 2019
5MW4
DownloadVisualize
BU of 5mw4 by Molmil
Crystal structure of Dot1L in complex with inhibitor CPD7 [N-(3-(((R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl)(methyl)amino)propyl)-2-(3-(2-chloro-3-(2-methylpyridin-3-yl)benzo[b]thiophen-5-yl)ureido)acetamide]
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, N~2~-{[2-chloro-3-(2-methylpyridin-3-yl)-1-benzothiophen-5-yl]carbamoyl}-N-(3-{methyl[(3R)-1-(5H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]amino}propyl)glycinamide, ...
Authors:Be, C, Koch, E, Gaul, C, Stauffer, F, Moebitz, H, Scheufler, C.
Deposit date:2017-01-18
Release date:2017-03-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
ACS Med Chem Lett, 8, 2017
5MW3
DownloadVisualize
BU of 5mw3 by Molmil
Crystal structure of Dot1L in complex with inhibitor CPD1 [N6-(2,6-dichlorophenyl)-N6-(pent-2-yn-1-yl)quinoline-4,6-diamine] and inhibitor CPD2 [(R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine]
Descriptor: (3R)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ...
Authors:Be, C, Koch, E, Gaul, C, Stauffer, F, Moebitz, H, Scheufler, C.
Deposit date:2017-01-18
Release date:2017-03-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
ACS Med Chem Lett, 8, 2017
5MVS
DownloadVisualize
BU of 5mvs by Molmil
Crystal structure of Dot1L in complex with adenosine and inhibitor CPD1 [N6-(2,6-dichlorophenyl)-N6-(pent-2-yn-1-yl)quinoline-4,6-diamine]
Descriptor: ADENOSINE, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ...
Authors:Be, C, Koch, E, Gaul, C, Stauffer, F, Moebitz, H, Scheufler, C.
Deposit date:2017-01-17
Release date:2017-03-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
ACS Med Chem Lett, 8, 2017
4ZSE
DownloadVisualize
BU of 4zse by Molmil
Crystal structure of EGFR 696-1022 T790M/V948R, crystal form II
Descriptor: 1,2-ETHANEDIOL, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Yan, X.E, Yun, C.H.
Deposit date:2015-05-13
Release date:2016-06-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Ibrutinib Selectively and Irreversibly Targets EGFR-mutant non-Small Cell Lung Cancer Cells
To Be Published
7V2Z
DownloadVisualize
BU of 7v2z by Molmil
ZIKV NS3helicase in complex with ssRNA and ATP-Mn2+
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Core protein, MANGANESE (II) ION, ...
Authors:Lin, M.M, Yang, H.T.
Deposit date:2021-08-10
Release date:2022-08-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.10101676 Å)
Cite:Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis.
Acs Infect Dis., 8, 2022
8HJT
DownloadVisualize
BU of 8hjt by Molmil
Crystal Structure of Intracellular B30.2 Domain of VpBTN3 and VpBTN2 in Complex with HMBPP
Descriptor: (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Butyrophylin 3, ...
Authors:Yang, Y.Y, Shen, P.P, Li, X, Yi, S.M, Zhang, M.T, Huang, J.-W, Chen, C.-C, Guo, R.-T.
Deposit date:2022-11-23
Release date:2023-09-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate V gamma 9V delta 2 T cells.
Nature, 621, 2023
5YU9
DownloadVisualize
BU of 5yu9 by Molmil
Crystal structure of EGFR 696-1022 T790M in complex with Ibrutinib
Descriptor: 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, CHLORIDE ION, Epidermal growth factor receptor
Authors:Yan, X.E, Yun, C.H.
Deposit date:2017-11-21
Release date:2017-12-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation.
Oncotarget, 7, 2016
4NWL
DownloadVisualize
BU of 4nwl by Molmil
Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide
Descriptor: HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-L-prolinamide, ZINC ION
Authors:Muckelbauer, J.K, Klei, H.E.
Deposit date:2013-12-06
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
J.Med.Chem., 57, 2014
4NWK
DownloadVisualize
BU of 4nwk by Molmil
Crystal structure of hepatis c virus protease (ns3) complexed with bms-605339 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-n-((1r,2s)-1-((cyclopropylsulfonyl)carba moyl)-2-vinylcyclopropyl)-4-((6-methoxy-1-isoquinolinyl)ox y)-l-prolinamide
Descriptor: GLYCEROL, HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-4-[(6-methoxyisoquinolin-1-yl)oxy]-L-prolinamide, ...
Authors:Muckelbauer, J.K, Klei, H.E.
Deposit date:2013-12-06
Release date:2014-03-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
J.Med.Chem., 57, 2014

221051

数据于2024-06-12公开中

PDB statisticsPDBj update infoContact PDBjnumon